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Database: UniProt
Entry: A0A1A9BP49_9ACTN
LinkDB: A0A1A9BP49_9ACTN
Original site: A0A1A9BP49_9ACTN 
ID   A0A1A9BP49_9ACTN        Unreviewed;       292 AA.
AC   A0A1A9BP49;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:SBT89655.1};
GN   ORFNames=GA0115233_101127 {ECO:0000313|EMBL:SBT89655.1};
OS   Streptomyces sp. DI166.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1839783 {ECO:0000313|EMBL:SBT89655.1, ECO:0000313|Proteomes:UP000198690};
RN   [1] {ECO:0000313|Proteomes:UP000198690}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DI166 {ECO:0000313|Proteomes:UP000198690};
RA   Varghese N., Submissions Spin;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HIBADH-related family.
CC       {ECO:0000256|ARBA:ARBA00009080}.
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DR   EMBL; FLSP01000011; SBT89655.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1A9BP49; -.
DR   STRING; 1839783.GA0115233_101127; -.
DR   OrthoDB; 3185659at2; -.
DR   Proteomes; UP000198690; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR   PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198690}.
FT   DOMAIN          6..162
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          168..286
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   ACT_SITE        174
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ   SEQUENCE   292 AA;  30064 MW;  13BD6CE9B26C9FE6 CRC64;
     MTDRLTVAVL GTGIMGAAMA RNLARAGHRV RAWNRTRAKA EPLTADGVLV ADGPAEAVRD
     ADVVLTILHD GPAALDVMRQ AAGGLRPGTA WVQSTTAGLD ALPGLADFAG EHALVLYDAP
     VLGTRQPAEA GRLTVLAAGP VEGREKVTPV FDAVGARTVW TGDDGAEGTA TRLKLVANSW
     VIAATAATGE TLALSRALGV DPQQFFDLIA GGPLDMGYLR AKAGLVLEER LSPPQFAVST
     AAKDARLIVE AGERGGVRLD VAAAGAARLE RAAAQGHGEE DMAAAYFASF DE
//
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