ID   A0A1A9BVS8_9ACTN        Unreviewed;       314 AA.
AC   A0A1A9BVS8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Hydroxymethylglutaryl-CoA lyase {ECO:0000313|EMBL:SBT91604.1};
GN   ORFNames=GA0115233_103235 {ECO:0000313|EMBL:SBT91604.1};
OS   Streptomyces sp. DI166.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1839783 {ECO:0000313|EMBL:SBT91604.1, ECO:0000313|Proteomes:UP000198690};
RN   [1] {ECO:0000313|Proteomes:UP000198690}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DI166 {ECO:0000313|Proteomes:UP000198690};
RA   Varghese N., Submissions Spin;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC       {ECO:0000256|ARBA:ARBA00009405}.
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DR   EMBL; FLSP01000032; SBT91604.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1A9BVS8; -.
DR   STRING; 1839783.GA0115233_103235; -.
DR   OrthoDB; 9784013at2; -.
DR   Proteomes; UP000198690; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016833; F:oxo-acid-lyase activity; IEA:InterPro.
DR   CDD; cd07938; DRE_TIM_HMGL; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR043594; HMGL.
DR   InterPro; IPR000891; PYR_CT.
DR   PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR   PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:SBT91604.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198690}.
FT   DOMAIN          21..288
FT                   /note="Pyruvate carboxyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS50991"
SQ   SEQUENCE   314 AA;  32905 MW;  082A599AECD4C9C5 CRC64;
     MSALGLALPM TVPAPGLPAR VRIHEVGARD GLQNEKATVP TEVKAEFIRR LADAGLTTIE
     ATSFVHPKWV PQLADAEQLF PQVSDLSVDL PVLVPNERGL DRALALGARR VAVFASATES
     FAKANLNRTV DEALAMFEPV VARAKADGVH VRGYLSMCFG DPWEGPVPAA QVVRVCTALL
     DLGCDELSLG DTIGVATPGQ VTALLTALSA EGVPTEALGV HFHDTYGQAL ANTLAALQYG
     VSTVDASAGG LGGCPYAKSA TGNLATEDLV WMLHGLGIDT GVDLGRLVAT SEWMADRLGR
     PSPSRTVRAL SHKE
//