ID   A0A1A9BY08_9ACTN        Unreviewed;       480 AA.
AC   A0A1A9BY08;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Glycine hydroxymethyltransferase {ECO:0000313|EMBL:SBT93097.1};
GN   ORFNames=GA0115233_105718 {ECO:0000313|EMBL:SBT93097.1};
OS   Streptomyces sp. DI166.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1839783 {ECO:0000313|EMBL:SBT93097.1, ECO:0000313|Proteomes:UP000198690};
RN   [1] {ECO:0000313|Proteomes:UP000198690}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DI166 {ECO:0000313|Proteomes:UP000198690};
RA   Varghese N., Submissions Spin;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the SHMT family.
CC       {ECO:0000256|ARBA:ARBA00006376}.
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DR   EMBL; FLSP01000057; SBT93097.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1A9BY08; -.
DR   STRING; 1839783.GA0115233_105718; -.
DR   OrthoDB; 9803871at2; -.
DR   Proteomes; UP000198690; Unassembled WGS sequence.
DR   GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:InterPro.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   InterPro; IPR001085; Ser_HO-MeTrfase.
DR   InterPro; IPR039429; SHMT-like_dom.
DR   PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11680:SF28; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR   Pfam; PF00464; SHMT; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000313|EMBL:SBT93097.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198690};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SBT93097.1}.
FT   DOMAIN          66..428
FT                   /note="Serine hydroxymethyltransferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00464"
SQ   SEQUENCE   480 AA;  51480 MW;  F022A7236B3FC132 CRC64;
     MRAAEQDSGV GLVDDGAQAA VEAAEEIIEE ASGGDGGVFA PAWSDDRVAH LLERLTSDFV
     LDNTYREQHL SLTASENYPS KLVRMLGSAL QGGFYEFAPP YPTEAGEWAF PDSGANASLV
     GKLTGIGRQL FEAATFDWRP NGGSVAEQAV LLGTCGRGDG FVHFAHKDGG HFALESLAAA
     AGVNTYHLPM VDRTLLIDVD RLATLCAEHP EIKLVILDQS FKLRWQPLAQ IRAALPEGVF
     LAYDASHDGA LIAGGALPQP TLLGADAVHG NTHKTIAGPQ KAYIAFRDAD HPRLRAVSDW
     VCPQMQSNSH AELIAPMYVA LSEIALYGHD YARQILANAK ALAHALHEEG VRVSGESFGF
     TETHQVHLVT GSAADALRLA LGDLAHAGIR TTNIEVPGAN GLHGLRLGVQ AMTRRGLRET
     EMREVARLVA KVVLRRAEPT TVRAEVADLL QSHPLDRLAF SFDSHVESPA AARLLGEVFR
//