UniProt: A0A1A9GKV5

Database: UniProt
Entry: A0A1A9GKV5_9ACTN

LinkDB:  A0A1A9GKV5_9ACTN 
Original site:  A0A1A9GKV5_9ACTN

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Ontology (10)   
   GO (10)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (18)   
   InterPro (10)   
   Pfam (3)   
   PROSITE (2)   
   SMART (3)   
All databases (32)   

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ID   A0A1A9GKV5_9ACTN        Unreviewed;       503 AA.
AC   A0A1A9GKV5;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=DNA-3-methyladenine glycosylase II {ECO:0000256|ARBA:ARBA00012000};
DE            EC=3.2.2.21 {ECO:0000256|ARBA:ARBA00012000};
GN   Name=alkA {ECO:0000313|EMBL:ANH38904.1};
GN   ORFNames=I601_2488 {ECO:0000313|EMBL:ANH38904.1};
OS   Nocardioides dokdonensis FR1436.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=1300347 {ECO:0000313|EMBL:ANH38904.1, ECO:0000313|Proteomes:UP000077868};
RN   [1] {ECO:0000313|EMBL:ANH38904.1, ECO:0000313|Proteomes:UP000077868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FR1436 {ECO:0000313|EMBL:ANH38904.1,
RC   ECO:0000313|Proteomes:UP000077868};
RA   Kwon S.-K., Kim K., Kim J.F.;
RT   "Complete genome sequence of a soil Actinobacterium, Nocardioides
RT   dokdonensis FR1436.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-
CC         methylguanine, 7-methylguanine and 7-methyladenine.; EC=3.2.2.21;
CC         Evidence={ECO:0000256|ARBA:ARBA00000086};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; CP015079; ANH38904.1; -; Genomic_DNA.
DR   RefSeq; WP_068110074.1; NZ_CP015079.1.
DR   AlphaFoldDB; A0A1A9GKV5; -.
DR   STRING; 1300347.I601_2488; -.
DR   KEGG; ndk:I601_2488; -.
DR   PATRIC; fig|1300347.3.peg.2480; -.
DR   OrthoDB; 9811249at2; -.
DR   Proteomes; UP000077868; Chromosome.
DR   GO; GO:0008725; F:DNA-3-methyladenine glycosylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052822; F:DNA-3-methylguanine glycosylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052821; F:DNA-7-methyladenine glycosylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0043916; F:DNA-7-methylguanine glycosylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd00056; ENDO3c; 1.
DR   Gene3D; 3.40.10.10; DNA Methylphosphotriester Repair Domain; 1.
DR   Gene3D; 3.30.310.20; DNA-3-methyladenine glycosylase AlkA, N-terminal domain; 1.
DR   Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR035451; Ada-like_dom_sf.
DR   InterPro; IPR004026; Ada_DNA_repair_Zn-bd.
DR   InterPro; IPR010316; AlkA_N.
DR   InterPro; IPR037046; AlkA_N_sf.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR003265; HhH-GPD_domain.
DR   InterPro; IPR023170; HhH_base_excis_C.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   PANTHER; PTHR43003; DNA-3-METHYLADENINE GLYCOSYLASE; 1.
DR   PANTHER; PTHR43003:SF13; DNA-3-METHYLADENINE GLYCOSYLASE 2; 1.
DR   Pfam; PF02805; Ada_Zn_binding; 1.
DR   Pfam; PF06029; AlkA_N; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM01009; AlkA_N; 1.
DR   SMART; SM00478; ENDO3c; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF57884; Ada DNA repair protein, N-terminal domain (N-Ada 10); 1.
DR   SUPFAM; SSF48150; DNA-glycosylase; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF55945; TATA-box binding protein-like; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Glycosidase {ECO:0000313|EMBL:ANH38904.1};
KW   Hydrolase {ECO:0000313|EMBL:ANH38904.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077868};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          95..193
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000259|PROSITE:PS01124"
SQ   SEQUENCE   503 AA;  53303 MW;  5CBE0DBE9BB3E785 CRC64;
     MTTRAEPRTR LDAESCYAAV KARDRRFDGL FWTAVRTTGI YCRPSCPART PAAGNVTFHP
     SAAAAQGAGY RACKRCLPDA TPGSPGWDVA AGVAGRAMRL VGDGVVDREG VDGLARRLGY
     SPRHLARVLT AELGAGPLAL ARARRAQTAR VLIETTDLPL TEVAFAAGFA SVRQFNQTVR
     EVYAVTPTQL RGRRTAAPTT GEISLRLAVR TPFAGQALLS FLAYHLVPGV ETAGAGFYAR
     TLDLPHGPGT VRLELDPALD EVPGGGVALL TARFRLTDLR DTAAAVERVR RLVDADCDPL
     PVAEHLGADP VLGPLARALP GLRLPGQVDG DETAVRTVVG QQVSVTGART VGGRIVAAHG
     RPVETGEPGL THLFPDAATL AEVDPETLPM PRARGRALVG LSAALARGDI ALDRGPQRDQ
     VRAAMVALPG IGPWTADYVA MRALGHPDVF LPTDLGVRTA LKRLGQEPAV AIARAPEWSP
     WRSYALMHLW QTLMPAPPTT EDD
//

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