ID A0A1A9NQ01_9PROT Unreviewed; 570 AA.
AC A0A1A9NQ01;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:OAJ71892.1};
GN ORFNames=A7976_10605 {ECO:0000313|EMBL:OAJ71892.1};
OS Methylobacillus sp. MM3.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Methylophilaceae; Methylobacillus.
OX NCBI_TaxID=1848039 {ECO:0000313|EMBL:OAJ71892.1, ECO:0000313|Proteomes:UP000077549};
RN [1] {ECO:0000313|EMBL:OAJ71892.1, ECO:0000313|Proteomes:UP000077549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MM2 {ECO:0000313|EMBL:OAJ71892.1,
RC ECO:0000313|Proteomes:UP000077549};
RA Macey M.C., Murrell J.C.;
RT "Draft genome of Methylobacillus sp. MM2 isolated from grassland soil.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAJ71892.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LXTQ01000001; OAJ71892.1; -; Genomic_DNA.
DR RefSeq; WP_067106648.1; NZ_LXTQ01000001.1.
DR AlphaFoldDB; A0A1A9NQ01; -.
DR STRING; 1848039.A7976_10605; -.
DR OrthoDB; 9781411at2; -.
DR Proteomes; UP000077549; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF1; CATION/PROTON ANTIPORTER YBAL-RELATED; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000077549};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 33..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 429..551
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 570 AA; 60573 MW; 2BDCE423E3A95D2A CRC64;
MPHEVSLITT IAAAFGLAMA MGFIASKLRM PPLVGYLVAG ILIGPATPGF DADMELASQL
AEIGVMLLMF GVGLHFSLDD LLAVKRIAVP GAIVQIAVAT ALGMVTATYW GWDIGAALVF
GLSLSVASTV VLLRALEARG VLDSINGRIA VGWLIVEDLV MVLVLVLLPV FAGFLGSSTE
EHAWDNEVWV TIGITLVKVT TFIALMLIVG RRLFPKLLWQ VARTGSRELF TLCVIAAAVV
VAYGSASLFG VSFALGAFFA GMMMRESEFS HRAADESLPL RDAFSVLFFV SVGMLFNPQV
LLDDPMKVLV VTAIIIFGKT LAAIVLVLAF RYPLNTALTV GASLAQIGEF SFILAGMGVS
LGLLGTEGQT LILAGALLSI ALNSLAFAAI EPAQVWIRSR SALARRLELS DDPLAQLPMS
TDQALLTGQV VLVGYGRVGK RIAESLNECG IPYVVAEQNR GIVEALRAHE IPAVSGDASD
PAVLIQAHIA RAGMLVIATP DTFAARKMVE TAKLLNPNVE VVVRTHSDEE ADLLTKENIG
KVFMGEHELA RGMTAHVLGR MGIGEPRKKH
//