GenomeNet

Database: UniProt
Entry: A0A1A9T1R9_9PROT
LinkDB: A0A1A9T1R9_9PROT
Original site: A0A1A9T1R9_9PROT 
ID   A0A1A9T1R9_9PROT        Unreviewed;       260 AA.
AC   A0A1A9T1R9;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00040167, ECO:0000256|RuleBase:RU366031};
DE            EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
GN   ORFNames=A7981_00155 {ECO:0000313|EMBL:OAM51950.1};
OS   Methylovorus sp. MM2.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylovorus.
OX   NCBI_TaxID=1848038 {ECO:0000313|EMBL:OAM51950.1, ECO:0000313|Proteomes:UP000077545};
RN   [1] {ECO:0000313|Proteomes:UP000077545}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MM1 {ECO:0000313|Proteomes:UP000077545};
RA   Macey M.C., Murrell J.C.;
RT   "Draft genome of Methylovorus sp. MM1 isolated from grassland soil.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC       hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC       {ECO:0000256|ARBA:ARBA00037589, ECO:0000256|RuleBase:RU366031}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC         Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC         ChEBI:CHEBI:57845; EC=4.2.1.75;
CC         Evidence={ECO:0000256|ARBA:ARBA00000783,
CC         ECO:0000256|RuleBase:RU366031};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004772, ECO:0000256|RuleBase:RU366031}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000256|ARBA:ARBA00008133, ECO:0000256|RuleBase:RU366031}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAM51950.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LXUF01000001; OAM51950.1; -; Genomic_DNA.
DR   RefSeq; WP_067262327.1; NZ_LXUF01000001.1.
DR   AlphaFoldDB; A0A1A9T1R9; -.
DR   STRING; 1848038.A7981_00155; -.
DR   OrthoDB; 9787650at2; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000077545; Unassembled WGS sequence.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR38042; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR38042:SF1; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366031};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW   ECO:0000256|RuleBase:RU366031};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077545}.
FT   DOMAIN          25..248
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
SQ   SEQUENCE   260 AA;  28395 MW;  78D5535D1D3B4460 CRC64;
     MPESTLSGFH VAVTRPIAQS TKLCDLIKSH GGQTISFPLI EIVSLDDYDD FDQKLLTLDN
     YDLAIFISSN AVNQGMPRLL THLKKIPPTL QFAAIGPTTA SELQKFGVQD ILTPENRFDS
     ESLLALPAML KVNAKRIIIF RGIGGREILA NTLRSRGATV DFAECYQRIN PQTNADVLSG
     LWQNKQLQAI VVTSSEAMRH LLDIAGQGEA DWIKNVTLCV NHARIAELPL ETGLKVMIAE
     ASGDAAMLQC LIEAATHSNT
//
DBGET integrated database retrieval system