ID A0A1A9UGG8_GLOAU Unreviewed; 1102 AA.
AC A0A1A9UGG8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=SANT domain-containing protein {ECO:0000259|PROSITE:PS51293};
OS Glossina austeni (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=7395 {ECO:0000313|EnsemblMetazoa:GAUT004035-PA, ECO:0000313|Proteomes:UP000078200};
RN [1] {ECO:0000313|Proteomes:UP000078200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TTRI {ECO:0000313|Proteomes:UP000078200};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GAUT004035-PA}
RP IDENTIFICATION.
RC STRAIN=TTRI {ECO:0000313|EnsemblMetazoa:GAUT004035-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR AlphaFoldDB; A0A1A9UGG8; -.
DR STRING; 7395.A0A1A9UGG8; -.
DR EnsemblMetazoa; GAUT004035-RA; GAUT004035-PA; GAUT004035.
DR VEuPathDB; VectorBase:GAUT004035; -.
DR OrthoDB; 5482374at2759; -.
DR Proteomes; UP000078200; Unassembled WGS sequence.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF39; SMRTER, ISOFORM G; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51293; SANT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 635..686
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 87..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 380..430
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 89..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1102 AA; 119622 MW; 821D67DFCEBEE14C CRC64;
MPEVREAPQR FILQSAYSIG PGAQYRESPY TRIPPMPPVQ DYHRVAAAAL AAANSTPGSG
GVVQMPPTSN VNISAPHGIE ALHFAHPSPG HQASSSGATQ LLNNAPSGGA AVSNANSPHN
TSNVSPAGNS NSCVTSSIMT GGGKRILLNT THRQQSPYSN EYLKNVAVPA TGTVSVNRHG
QTQPPPDPGG QPPYKKMRLS DANNSATNNL PPHQVTNVQS STPQQQQQRQ PSPVTAQTPN
VVRTSGHGHG QILPPHTHLS ALPPSHIPQH QQHVPPPPQS VTMQQLKVET QSLHMPVVVT
PPVNRVAASA PISSVINVAS ATTATTNSPS ISVSVTTTIN STSSSTEAYH PQVEAISPTL
PIDSAEERGR TAKEDLLMQI QKVDTEITSA DNALDALRTK EKNLMDVAAA AKQQKEMAAA
AKKQAETEAE TDAQNFWRSQ TLAQKIYLAN QKTAAAQHSI LDNCGERYLL PLYNQPLDVD
HLTIVIQRHQ TIIKMPLLDH LRKIKNERWI HHTKLVETYA QLSTEWQKRV DKAEGSAKRK
TRESKNREFF EKVFTELRKQ REDKERFNRV GSRIKSEADY EEIMDGLQEQ AMEVRKMRSY
AIIPPLMFNT YQRRCLYHNE NGAVKDMVAV HKERAVLNVW TAGEKEIFKE KFLQHPKNFG
AIAASLDRKS AQDCVRYYYL SKKTENYKQL LRKSRQRTRA SKTLQKTQQQ PTQCIIDSLT
TGVTTRLQRE QQQKTGGRSA AAERERERAE RAAEREKTVE KTVTETTKAV TTTTIKTIKL
EAVSVTTVTA ATAVNTNVET PAAISADDLF VAAADTSKVP NGAKNISTPN SSNITTTTCM
SADKSQAEKL ATAIESHNRT NLATEQENNT KVNSPESTSN GSNKAKFENK VSDNHDNKKS
MNALSVSPEK STEKISVTSS GAATSVNSNT VASQQTNASV DSALLSSSAS LISQMPTTSM
ASLNNIVHPS SSMPNGIKTS YAGTIPIQIG SAVATTTASP SKTPLINAAS DEIKRETSNI
GNENKETNIN AESVVAEDTN NKLSVVSTPT TSTSAGNFLG QKLKAAQVES VSDPGNDCNS
DVRAPLMCRN TLEMYSFYEA LT
//
