ID A0A1A9UV75_GLOAU Unreviewed; 433 AA.
AC A0A1A9UV75;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Saccharopine dehydrogenase NADP binding domain-containing protein {ECO:0000259|Pfam:PF03435};
OS Glossina austeni (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=7395 {ECO:0000313|EnsemblMetazoa:GAUT016726-PA, ECO:0000313|Proteomes:UP000078200};
RN [1] {ECO:0000313|Proteomes:UP000078200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TTRI {ECO:0000313|Proteomes:UP000078200};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GAUT016726-PA}
RP IDENTIFICATION.
RC STRAIN=TTRI {ECO:0000313|EnsemblMetazoa:GAUT016726-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00038048}.
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DR AlphaFoldDB; A0A1A9UV75; -.
DR STRING; 7395.A0A1A9UV75; -.
DR EnsemblMetazoa; GAUT016726-RA; GAUT016726-PA; GAUT016726.
DR VEuPathDB; VectorBase:GAUT016726; -.
DR OrthoDB; 3491613at2759; -.
DR Proteomes; UP000078200; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 270..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..140
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
SQ SEQUENCE 433 AA; 49931 MW; 59144163108D6F23 CRC64;
MKTNKAFDII IFGASGFVGR HTVLKAVTMF KNLSWAVAGR NREKLQLIVC QIAERTFKDL
RELPILIADV RDESSIIRMV ENCEVLINCC GPIQLCGEVI IKNCIKSGTH YVDISNDPYF
NELMQLKYHE SAKENNIYVV SACGFQSFAM EMGLNFMHEN FNGTINYVDA YVKYSCTNPH
VPFGPIGSDT VWKSMILACS KIGELPQIRQ RLRQKPWPVL LPKQPIKRLL HRPDQQSRVT
FVRFPLIDQQ DIERSQYYFY KLDKQRPIQF YKYLVFPSFL LAFLFALWTL LISLMANFDK
TREIVIEYPR LFSVGLFSPK GPDLRIVANI KFQMTLYGVG WSRYPIHSIY ELNDERLDQA
MCLEISGTNP IYNVGCLCLL LSALTVLQEQ NVMPSNGGVY PPGYAFKGTS LFNRMEYYDN
YINIRISEPV HSM
//
