ID A0A1A9VAE8_GLOAU Unreviewed; 1094 AA.
AC A0A1A9VAE8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Glossina austeni (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=7395 {ECO:0000313|EnsemblMetazoa:GAUT030956-PA, ECO:0000313|Proteomes:UP000078200};
RN [1] {ECO:0000313|Proteomes:UP000078200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TTRI {ECO:0000313|Proteomes:UP000078200};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GAUT030956-PA}
RP IDENTIFICATION.
RC STRAIN=TTRI {ECO:0000313|EnsemblMetazoa:GAUT030956-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A1A9VAE8; -.
DR STRING; 7395.A0A1A9VAE8; -.
DR EnsemblMetazoa; GAUT030956-RA; GAUT030956-PA; GAUT030956.
DR VEuPathDB; VectorBase:GAUT030956; -.
DR OrthoDB; 1630at2759; -.
DR Proteomes; UP000078200; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR CDD; cd13982; STKc_IRE1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954:SF6; ENDORIBONUCLEASE; 1.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 5.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1094
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008399206"
FT TRANSMEM 483..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 554..829
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 832..974
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 512..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1063..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1094
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1094 AA; 123626 MW; 6A84F5C3F1A0FF0A CRC64;
MKNFLRIFCL VFACEHIFIA SADAAAESPG PTILNSINNI GIADELSNSR KDCTDVARDE
ETLMVFSTLG GGLTAIDPIT SEIRWIIADD PPVMAEQQQN VHVPQYLPDP RDGSIYQLSD
RGNLKKLPYT IPQLVANAPC RSSDGILYSG KKSDTWFIVD PKTGRREKVS FEDSVSGGKN
SIGWATSRSI YLGRTQYTVM MYDSLTKDKN AKPWNITFYD YSAMATTPDI SKDYEYLHLT
TTSSGNILTL NRKDGKFMWK NDLTSPVVAA FLLGSEGLLS IPFTTVSEEA FEAILEESKE
GNVNTIKLFQ TLYVGECRHG LYALPSLVDK STPRISTAPA IKLLDGPHSN AKDDDSKTVY
VNEVFEKNAG ILLGHYNVPN DVTLQIAPSK TVDNDNIDRG LATINAALNG PGLSILSSDK
EKQSSDVGVQ TDPVIDMEIE STNSNKSSEN NAFKKTKKII LLNSGKVQRF LNEWFMEHPS
GQVHQILFII ILLMVAMFWY MRSLTRELKN QSENASKTYE NSSGNSRGSN GSNVSNQEPD
DLGNGYVRIG KISFNSNEVL GKGCEGTFVF RGTFEERFVA VKRLLPECFT FADREVALLR
ESDAHENVVR YFCTEEDRQF RYIAVELCAA TLQDYTEGER SSELRSQIAV WEVLKQSAEG
LNHLHSLSIV HRDIKPHNVL LSYPDINGTV RVMISDFGLC KKLHHGKTSF SRRSGVTGTE
GWIAPEMMRG QRTVKRTVLE IPVVTTSVDI FSLGCVYYYV LSKGYHVFGD ALKRQANILT
YDFNICHLKA ETKEEQSKII LAGQLIVDMI HKEPQSRPPA NCIRNHPVFW NNQTILAFFQ
DVSDRVEKLQ FDVEPLKSLE RNGNSVVLGD WHLHLDSVIT IDLRKYRGYM GASVRDLLRA
LRNKVGRVSF YDKCKNANKH HYHELSAEMQ QLLGTIPNEF TNYWISKFPN LVSHTYHAFS
VCSNEPIFRP YYNSSYHFTR PEYFEADDEL YPILLKRDPK PLPKQSPINS NSKKTFQHLK
LRKGAYNFHK QMADEDFQME EGDVAENRNK FSNFKFRRFS KMSNRHSHNS NQGNSNICQQ
AKDGVLTSTP KEND
//