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Database: UniProt
Entry: A0A1A9VAE8_GLOAU
LinkDB: A0A1A9VAE8_GLOAU
Original site: A0A1A9VAE8_GLOAU 
ID   A0A1A9VAE8_GLOAU        Unreviewed;      1094 AA.
AC   A0A1A9VAE8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS   Glossina austeni (Savannah tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=7395 {ECO:0000313|EnsemblMetazoa:GAUT030956-PA, ECO:0000313|Proteomes:UP000078200};
RN   [1] {ECO:0000313|Proteomes:UP000078200}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TTRI {ECO:0000313|Proteomes:UP000078200};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GAUT030956-PA}
RP   IDENTIFICATION.
RC   STRAIN=TTRI {ECO:0000313|EnsemblMetazoa:GAUT030956-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   AlphaFoldDB; A0A1A9VAE8; -.
DR   STRING; 7395.A0A1A9VAE8; -.
DR   EnsemblMetazoa; GAUT030956-RA; GAUT030956-PA; GAUT030956.
DR   VEuPathDB; VectorBase:GAUT030956; -.
DR   OrthoDB; 1630at2759; -.
DR   Proteomes; UP000078200; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd09769; Luminal_IRE1; 1.
DR   CDD; cd10422; RNase_Ire1; 1.
DR   CDD; cd13982; STKc_IRE1; 1.
DR   Gene3D; 1.20.1440.180; KEN domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR045133; IRE1/2-like.
DR   InterPro; IPR010513; KEN_dom.
DR   InterPro; IPR038357; KEN_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR13954:SF6; ENDORIBONUCLEASE; 1.
DR   PANTHER; PTHR13954; IRE1-RELATED; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF06479; Ribonuc_2-5A; 1.
DR   SMART; SM00564; PQQ; 5.
DR   SMART; SM00580; PUG; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   PROSITE; PS51392; KEN; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..1094
FT                   /note="non-specific serine/threonine protein kinase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008399206"
FT   TRANSMEM        483..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        737..760
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          554..829
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          832..974
FT                   /note="KEN"
FT                   /evidence="ECO:0000259|PROSITE:PS51392"
FT   REGION          512..540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1063..1094
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1065..1094
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1094 AA;  123626 MW;  6A84F5C3F1A0FF0A CRC64;
     MKNFLRIFCL VFACEHIFIA SADAAAESPG PTILNSINNI GIADELSNSR KDCTDVARDE
     ETLMVFSTLG GGLTAIDPIT SEIRWIIADD PPVMAEQQQN VHVPQYLPDP RDGSIYQLSD
     RGNLKKLPYT IPQLVANAPC RSSDGILYSG KKSDTWFIVD PKTGRREKVS FEDSVSGGKN
     SIGWATSRSI YLGRTQYTVM MYDSLTKDKN AKPWNITFYD YSAMATTPDI SKDYEYLHLT
     TTSSGNILTL NRKDGKFMWK NDLTSPVVAA FLLGSEGLLS IPFTTVSEEA FEAILEESKE
     GNVNTIKLFQ TLYVGECRHG LYALPSLVDK STPRISTAPA IKLLDGPHSN AKDDDSKTVY
     VNEVFEKNAG ILLGHYNVPN DVTLQIAPSK TVDNDNIDRG LATINAALNG PGLSILSSDK
     EKQSSDVGVQ TDPVIDMEIE STNSNKSSEN NAFKKTKKII LLNSGKVQRF LNEWFMEHPS
     GQVHQILFII ILLMVAMFWY MRSLTRELKN QSENASKTYE NSSGNSRGSN GSNVSNQEPD
     DLGNGYVRIG KISFNSNEVL GKGCEGTFVF RGTFEERFVA VKRLLPECFT FADREVALLR
     ESDAHENVVR YFCTEEDRQF RYIAVELCAA TLQDYTEGER SSELRSQIAV WEVLKQSAEG
     LNHLHSLSIV HRDIKPHNVL LSYPDINGTV RVMISDFGLC KKLHHGKTSF SRRSGVTGTE
     GWIAPEMMRG QRTVKRTVLE IPVVTTSVDI FSLGCVYYYV LSKGYHVFGD ALKRQANILT
     YDFNICHLKA ETKEEQSKII LAGQLIVDMI HKEPQSRPPA NCIRNHPVFW NNQTILAFFQ
     DVSDRVEKLQ FDVEPLKSLE RNGNSVVLGD WHLHLDSVIT IDLRKYRGYM GASVRDLLRA
     LRNKVGRVSF YDKCKNANKH HYHELSAEMQ QLLGTIPNEF TNYWISKFPN LVSHTYHAFS
     VCSNEPIFRP YYNSSYHFTR PEYFEADDEL YPILLKRDPK PLPKQSPINS NSKKTFQHLK
     LRKGAYNFHK QMADEDFQME EGDVAENRNK FSNFKFRRFS KMSNRHSHNS NQGNSNICQQ
     AKDGVLTSTP KEND
//
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