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Database: UniProt
Entry: A0A1A9VCB5_GLOAU
LinkDB: A0A1A9VCB5_GLOAU
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ID   A0A1A9VCB5_GLOAU        Unreviewed;       575 AA.
AC   A0A1A9VCB5;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   03-JUL-2019, entry version 14.
DE   RecName: Full=Receptor protein serine/threonine kinase {ECO:0000256|SAAS:SAAS00138132};
DE            EC=2.7.11.30 {ECO:0000256|SAAS:SAAS00138132};
OS   Glossina austeni (Savannah tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Hippoboscoidea; Glossinidae; Glossina.
OX   NCBI_TaxID=7395 {ECO:0000313|Proteomes:UP000078200, ECO:0000313|VectorBase:GAUT032743-PA};
RN   [1] {ECO:0000313|VectorBase:GAUT032743-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TTRI {ECO:0000313|VectorBase:GAUT032743-PA};
RA   Wicklow D.T.;
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000078200}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TTRI {ECO:0000313|Proteomes:UP000078200};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|VectorBase:GAUT032743-PA}
RP   IDENTIFICATION.
RC   STRAIN=TTRI {ECO:0000313|VectorBase:GAUT032743-PA};
RG   VectorBase;
RL   Submitted (JUL-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
CC         phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
CC         COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.30;
CC         Evidence={ECO:0000256|SAAS:SAAS01128400};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-threonine + ATP = [receptor-
CC         protein]-O-phospho-L-threonine + ADP + H(+);
CC         Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-
CC         COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.30; Evidence={ECO:0000256|SAAS:SAAS01128404};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC       {ECO:0000256|SAAS:SAAS00595019}.
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DR   VectorBase; GAUT032743-RA; GAUT032743-PA; GAUT032743.
DR   Proteomes; UP000078200; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR000472; Activin_recp.
DR   InterPro; IPR003605; GS_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 1.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   SMART; SM00467; GS; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00138218};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000078200};
KW   Kinase {ECO:0000256|SAAS:SAAS00138139};
KW   Membrane {ECO:0000256|SAAS:SAAS00138203, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00138212};
KW   Receptor {ECO:0000256|SAAS:SAAS00138179};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078200};
KW   Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00138186};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00138167};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00138220,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00488859,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    575       Receptor protein serine/threonine kinase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008399247.
FT   TRANSMEM    172    194       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      226    255       GS. {ECO:0000259|PROSITE:PS51256}.
FT   DOMAIN      256    556       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   COILED      552    572       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   575 AA;  65089 MW;  74E97010ABC8DF1E CRC64;
     MAAIIKLIIL LIVLQINKAK GEINGRSMDD YRKNMSHEIS YTNNSKEYPS LLPQNSIQTH
     PRFKCFSCEP PCHNASQHAH MCQNAIQCFK SRVRNAFGEE EVSRGCINSP DQTPLICSAN
     NIKSLNPRKR HTASPVNVAC CAGDYCNGGE FPELLNTEIT RLNDDRSNLL KLLFAILGPI
     VAISILAYIA IYFIRRKHRK RLPSSRTKQD PDTYLMNDER VTIGDSTLRE YLQHSVTSGS
     GSGLPVFIQR TLNKQVSLIE CIGRGKYGEV WRGQWHGENV AVKIFTSRDE NSWRRETEIY
     CTVALRHENI LGFIGSDIAS RNSCTQLWLL THYHPNGSLM DYLSRNTLTH EKMISICLSI
     ANGLEHIHSE ITHSSEISGI EGSSAKPAMA HRDLKSKNIL VKSNGTCVIA DFGLAVTHSN
     VTGKLDLGNN PKVGTKRYMA PEVLDESIDM QRFDSLRPTD IYALGLILWE VCRRTISSGK
     FEEYKVPYYD VVPADPSFED MRKVVCTDNY RPSIPNRWSS DPLLEDMSKL MKECWRRNPV
     ARVSVLRVRK TIQKLAAAEK LKNEKMKSYE DEICV
//
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