ID A0A1A9VEF5_GLOAU Unreviewed; 785 AA.
AC A0A1A9VEF5;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
OS Glossina austeni (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=7395 {ECO:0000313|EnsemblMetazoa:GAUT034712-PA, ECO:0000313|Proteomes:UP000078200};
RN [1] {ECO:0000313|Proteomes:UP000078200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TTRI {ECO:0000313|Proteomes:UP000078200};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GAUT034712-PA}
RP IDENTIFICATION.
RC STRAIN=TTRI {ECO:0000313|EnsemblMetazoa:GAUT034712-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A1A9VEF5; -.
DR STRING; 7395.A0A1A9VEF5; -.
DR EnsemblMetazoa; GAUT034712-RA; GAUT034712-PA; GAUT034712.
DR VEuPathDB; VectorBase:GAUT034712; -.
DR OrthoDB; 3015718at2759; -.
DR Proteomes; UP000078200; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13751; TGF_beta_GDF8_like; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF291; LD29161P; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 676..785
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 326..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 785 AA; 90556 MW; 372074686796B46F CRC64;
MCSNYKYFRR QDIQAEINEK NLIAARNTIP NRRWSRISVH KNKNSNIINN ALKTHCKIKN
ESSQASQRCQ SFNENRSASL STLSTIQLND HKCNERLFKC TKYIQSYKPL LRKWRPADTT
IRRSVGSKSC QTKKKSLMYS TQITSSINTK YVITSNKKWF QKCILKQNPK NSSNGLQINT
LVSKATSYVL PTFLRLLGRF VLEFCRSSPF FIVALIICLI LHSSYAATSQ TTLPSKPTSS
VMPSETFVVP QVANNSSTRL QGLTLAFGIT ENSFYTNYTT ITPLVSTGDQ LQSLIPKELN
WEIGSQDNNE NVISYINRQI ILNHRHRGQH QQIGPKQSRN ENESKNNIND ETIVYNQRKE
TYNNSPQSDN FTSASSCYSC QMRERAKLDN LESIKRHILM RLHMSQLPNI TDPPVVPQII
LENFYKSFHT SKASAASTYN MRYPAQQDHS IGYKPSSSVK SNYDEDGNNH DEDDETINFD
NKMQGDSPQR LYNILNYNSE EESYDEFYSH LHSVFIFPTT TRLRHNHKPE VLNFNLHCDA
SNIARAFLHV YIRGHSWMRD RHPELLEYKH SDGRTEQRRE VIISVHRALR RPNSANYTHT
VKLIEVKCKI PLGFGQWTEI EMKQLSMYWL ANANATQSLI INGNESWMRP FIVTDSKTSN
RALRIHIELM TKAPKRNKRS ASLDCREGDN EVRCCRYPLR VNFKELNWTF IMAPGYFDAY
FCNGNCKAGY LEQYTHTHLT TLSTSATPCC APSKMSPLPL LYFTAHEELL MTVIPNMSVD
KCSCF
//
