ID A0A1A9VK36_GLOAU Unreviewed; 610 AA.
AC A0A1A9VK36;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 22-FEB-2023, entry version 31.
DE RecName: Full=CBS domain-containing protein {ECO:0000259|PROSITE:PS51371};
OS Glossina austeni (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=7395 {ECO:0000313|EnsemblMetazoa:GAUT039627-PA, ECO:0000313|Proteomes:UP000078200};
RN [1] {ECO:0000313|Proteomes:UP000078200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TTRI {ECO:0000313|Proteomes:UP000078200};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GAUT039627-PA}
RP IDENTIFICATION.
RC STRAIN=TTRI {ECO:0000313|EnsemblMetazoa:GAUT039627-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC {ECO:0000256|ARBA:ARBA00009749}.
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DR AlphaFoldDB; A0A1A9VK36; -.
DR STRING; 7395.A0A1A9VK36; -.
DR EnsemblMetazoa; GAUT039627-RA; GAUT039627-PA; GAUT039627.
DR VEuPathDB; VectorBase:GAUT039627; -.
DR OrthoDB; 3740525at2759; -.
DR Proteomes; UP000078200; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR CDD; cd04606; CBS_pair_Mg_transporter; 1.
DR Gene3D; 1.10.3730.20; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.25.60.10; MgtE N-terminal domain-like; 1.
DR Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR006668; Mg_transptr_MgtE_intracell_dom.
DR InterPro; IPR038076; MgtE_N_sf.
DR InterPro; IPR006669; MgtE_transporter.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR InterPro; IPR045324; Small_multidrug_res.
DR PANTHER; PTHR43773; MAGNESIUM TRANSPORTER MGTE; 1.
DR PANTHER; PTHR43773:SF1; MAGNESIUM TRANSPORTER MGTE; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01769; MgtE; 1.
DR Pfam; PF03448; MgtE_N; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
DR SMART; SM00116; CBS; 1.
DR SMART; SM00924; MgtE_N; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF161093; MgtE membrane domain-like; 1.
DR SUPFAM; SSF158791; MgtE N-terminal domain-like; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 402..458
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 610 AA; 68251 MW; 2A540C03F531221F CRC64;
MALSTYLLSL AIRSIPIGVC YAIWTGVGAI GASILGVYLF YEPVNLFELD ESETKIFEIV
FIAGFQQNQY REHQQCSAFE KQYQDPEWDL KKKHLLSDQH QAKNTPKGKV VLRIEKLRNS
HILGFNMLYV IPPTASAAIV TAATAIIMGI NSTATVPVAK SVTAIAVLSA AVAQPAIIPH
LPHFLDYHEQ LSVTMRIEYF RLETDKKAID DLIESLDNEE LENVRNIVKT IDSVQLAYFL
STSISDHREK LVNILDQHLL SDALVHVVPD LQREIIETLG IENTAKLLML LDVEDVVTIV
KDLDRKSIEN ILNYLPNATQ KLVEELLSYP EESAGRLIHK DMVIAPYYWT INQLTEFVCN
YKKIPERFHQ IFIINSKLEP IGSVNLNKVI SHSGDTIIKE IMDHEIKIIK TGVDQEEVAR
IFKDYSLLSA PVVNKNGKII GVILIEDVIK VVQQETEEDV LKISGVSSKA DINAPIHKTI
IKRLPWLLFN LLAATMCSIV VGFFDDVIKS FIVLPIIMPI IASMSGNAGS QTVTLTIRAI
ATKYLTEQNA KRVLMKEFLI GLINGLPEGP IKLLNPGPEF VSVAETELML VIKSALLNCP
CGCDARYRFK
//
