ID A0A1A9VSJ8_GLOAU Unreviewed; 394 AA.
AC A0A1A9VSJ8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Mab-21 domain-containing protein {ECO:0000313|EnsemblMetazoa:GAUT046065-PA};
OS Glossina austeni (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=7395 {ECO:0000313|EnsemblMetazoa:GAUT046065-PA, ECO:0000313|Proteomes:UP000078200};
RN [1] {ECO:0000313|Proteomes:UP000078200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TTRI {ECO:0000313|Proteomes:UP000078200};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GAUT046065-PA}
RP IDENTIFICATION.
RC STRAIN=TTRI {ECO:0000313|EnsemblMetazoa:GAUT046065-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the mab-21 family.
CC {ECO:0000256|ARBA:ARBA00008307}.
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DR AlphaFoldDB; A0A1A9VSJ8; -.
DR EnsemblMetazoa; GAUT046065-RA; GAUT046065-PA; GAUT046065.
DR VEuPathDB; VectorBase:GAUT046065; -.
DR OrthoDB; 2902842at2759; -.
DR Proteomes; UP000078200; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:1902615; P:immune response involved in response to exogenous dsRNA; IEA:UniProt.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1410.40; -; 1.
DR Gene3D; 3.30.460.90; -; 1.
DR InterPro; IPR024810; Mab-21-like.
DR InterPro; IPR046903; Mab-21-like_nuc_Trfase.
DR InterPro; IPR046906; Mab-21_HhH/H2TH-like.
DR PANTHER; PTHR10656; CELL FATE DETERMINING PROTEIN MAB21-RELATED; 1.
DR PANTHER; PTHR10656:SF76; CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF03281; Mab-21; 1.
DR Pfam; PF20266; Mab-21_C; 1.
DR SMART; SM01265; Mab-21; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 58..237
FT /note="Mab-21-like nucleotidyltransferase"
FT /evidence="ECO:0000259|Pfam:PF03281"
FT DOMAIN 242..335
FT /note="Mab-21-like HhH/H2TH-like"
FT /evidence="ECO:0000259|Pfam:PF20266"
FT REGION 372..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 394 AA; 46485 MW; 4CAFB4FD3F495795 CRC64;
MRNLEEVLND INKYINIDKD RQKYASNFVI LRDTIFNKLR KGEPFGSIFK GFQLGGSYGD
NLKVTKPNEY DLVFHIRFPD NNLIVVRKDN DLPGNVHIDL TKVMEKIRKE KQNEVIYKHL
SRWVNDKNYL IINKLQSYFF SCFTKVMQEL NNRIDVNNEV FKLRYTRAGP AHTVEVTGDI
GFNYSVDFVP GILLEEKQSI LPGVGQWEAI PKPLFLAPKD YTSFRASYYR EEHKLIGNKH
NLKNALRMLK KFRDAHQNML KMKSYFIKTL FLWKAKEENY TNYWRQSLSL IIIDMFKDME
KSFNQRNLPF FWNSRLNLYE AYSFNVLTEM FKCVQSARET LEKANVELTI PLEPRVYRIF
LTMAEIQQSP AKNVTNNNSS PISENNELQP CSIL
//
