ID A0A1A9VSW6_GLOAU Unreviewed; 2118 AA.
AC A0A1A9VSW6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS01186};
OS Glossina austeni (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=7395 {ECO:0000313|EnsemblMetazoa:GAUT046362-PA, ECO:0000313|Proteomes:UP000078200};
RN [1] {ECO:0000313|Proteomes:UP000078200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TTRI {ECO:0000313|Proteomes:UP000078200};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GAUT046362-PA}
RP IDENTIFICATION.
RC STRAIN=TTRI {ECO:0000313|EnsemblMetazoa:GAUT046362-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR STRING; 7395.A0A1A9VSW6; -.
DR EnsemblMetazoa; GAUT046362-RA; GAUT046362-PA; GAUT046362.
DR VEuPathDB; VectorBase:GAUT046362; -.
DR OrthoDB; 3107655at2759; -.
DR Proteomes; UP000078200; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF13; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF00058; Ldl_recept_b; 10.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 7.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 15.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT TRANSMEM 2001..2024
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 707..722
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 769..811
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 812..854
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 855..898
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 899..941
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1083..1125
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1126..1168
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1169..1212
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1213..1254
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1387..1429
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1430..1472
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1473..1516
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1517..1558
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1692..1735
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1736..1778
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1779..1822
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 33..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..79
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 313..328
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 364..379
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 385..397
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 392..410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 404..419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 424..436
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 431..449
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 443..458
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 493..508
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 515..527
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 522..540
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 534..549
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 560..572
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 567..585
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 579..594
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 624..639
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 2118 AA; 239677 MW; BCDFFF22FDB696A5 CRC64;
MRRCMFGPSR CVCAFKSLRH LFQSSLQDYL QSPSDTAEVT QTLCNDDDDD DNDDDEDYND
DDDDNNDDDD DDDDDDDVHG DYGYPTTTWH GLTDLESKAE YGSASKQLLI PNHVRDYVGF
YHQRQERLKP QLRSAGGITK EFHTSSPKSG DSDKYHESED HANYDDYVIH PSDTPSHDIS
DDDYFVPELS HYPHEIFTTE PLQQQTSHEV GQGFNPGESA RHRDVGARSG SRTDLYGVRE
SGDRREMTRG REGYMNMLHT KQKVFRPHVS LVHDETRLAS PNDGYRRDCP NICGEMQWQC
ATKCNCIHAN ERCDKEPQCE DGSDEYDCDV VGDMMSKLQR ECEQTGMHVM CPKTYRCINK
EWLCDGDDDC GDYSDETHCG ERINCTEDQF ECANGFCIPK QWLCDGENDC KDFSDEGHCN
RTSCSNEHFT CNDGYCVSIA FRCDGERDCN DNSDEYKCPA VINSCPEGEF KCRGGLGGAG
GPSGQCVLNR FLCDGDNDCG DWSDEENCPQ KPSQCTSSEL KCADGTCIPK RWKCDKEQDC
DGGEDEHDCG NMNSSLHSSC GTDEFTCNNG RCILRTWLCD GYPDCSSAED EVECHLQCES
GQFLCPAKKN ITNLKICVHQ KHVCDGQNDC PFGEDEINCP HYRDCESDAK CEQLCITTAK
GRKECACRLG FLMHKNKQNC TDIDECQYLS SPVCSQKCEN TYGSFVCSCE RGYVLRPDLR
TCKALGGAMT LIVANRWDIR RVTLSNNRYA ALVKGLHNAI ALDYHFKKGI LFWSDVSTDV
IKTVYMNGTR VRDVIKWGLE APGGVAVDWI HDLLFWTDSG TRRVEVSNFQ GNLRSVIVSN
DLDKPRAIVV HPGEAMVFWT DWGPNPKIER AYMDGSQRQI IINKGVTWPN GLAIDYPSNK
LYWADAKQHA IECSNFDGSE RIKILSTHLP HPFAITIFED TMYWTDWNTK TVSAANKITG
KGFRSVHENF HFPMDIHAYH PARQPEYPDR CQKDRRGLRG GCSHFCLPNK NSRRCGCPIG
LSLKDDGKTC KSAPEKLVLV ARRKDIRLRQ IHAKSSTYND VDMIIPLDNL KHAVALDWTS
DSDTIYWTDV EKSSINKAYL NGSHQQKVIH SNLVSPAGLA LDWLTDKLYW TDPSTNRIEV
ATSNGKIRTL LIWDLLDKPR DIVVNPIEGL MFWSDWGDRP MIECAHMDGK KRRVVTSENL
KWPNGLAIDY EQQRLYFVDG GTKSLEYMNF DGSERKTLLG GLGHPFGLDV SESRVYWTDW
DLKAALSADK QTGKNMTTVI ANSSDLMDIS VFHRYRKRIS HACANDNGGC SHLCLLNPIS
YSCACPVGIT IQPDNRTCSS GPSKYIIFAH RVDIRQISMD FDHLIDVVLP LPPISNAVAL
DVDRKTGQIY WSDIVDSLIM SSSPDGLNVN RIIYESLDSP DGLVIDSVGR TLYWADAGRH
TVEVATLDGR YRHLIAWKDL ESPRGLALDY EAGFLFWTDW GHYRKIERAY MDGENRQRIV
TSNLLWPNGL SLDLKAKRIY WVDAKLKVID SCDYDGNQRK LIMSALHHPY ALALTDEFIY
WTDWKSKALH MADRNNVSDK RDVMTNIDGL MDIKVISTNE KLPSNACGEN NGGCSQLCLR
NPSGYTCKCG IGLKLINGNS TECEYLPEDY LLIALRSGIG LISLTTPDLM DVVLPIPGVH
GVVVLDYHYR RNWLYIADVN LDIIRRVSLK NLTESKVIIN TKLATPNGIA VDWIADNIYW
SDSDHRIIEV ARLDGSCRKS ILSDDMGDPR SLIVHPKRGY LFWSDWDTPS RIERCLLDGS
NRTILVGNNL GFPTGLTIDF ENRRLLWADA LEDNIGQVDF NGKHRTVIIP YASHPFGLTM
FENSIFWTDW YNKSVYRAYR EGRSFSQPVE IRDSLSGALD IRAVSLKRQL QEWNQCAQDN
GGCSHLCLFR GLDYVCACPD QIDHSRECST SPKFYVPPQQ RLDENLADYT DEVTESDNPM
LTEDDFGDDY RIKKSSRRET LILIAIGIVI ILLVISVTAI IYLVHNSKRT KSKRHKRGGS
SRSVLTFSNP NYNVDGTPIE PKTTIWKRFK SDRIHERVYE ERSLTTETAS SSLFVPTPSP
ATSPSVKKIQ LSTLSTIA
//