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Database: UniProt
Entry: A0A1A9VSW6_GLOAU
LinkDB: A0A1A9VSW6_GLOAU
Original site: A0A1A9VSW6_GLOAU 
ID   A0A1A9VSW6_GLOAU        Unreviewed;      2118 AA.
AC   A0A1A9VSW6;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS01186};
OS   Glossina austeni (Savannah tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=7395 {ECO:0000313|EnsemblMetazoa:GAUT046362-PA, ECO:0000313|Proteomes:UP000078200};
RN   [1] {ECO:0000313|Proteomes:UP000078200}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TTRI {ECO:0000313|Proteomes:UP000078200};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GAUT046362-PA}
RP   IDENTIFICATION.
RC   STRAIN=TTRI {ECO:0000313|EnsemblMetazoa:GAUT046362-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   STRING; 7395.A0A1A9VSW6; -.
DR   EnsemblMetazoa; GAUT046362-RA; GAUT046362-PA; GAUT046362.
DR   VEuPathDB; VectorBase:GAUT046362; -.
DR   OrthoDB; 3107655at2759; -.
DR   Proteomes; UP000078200; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   CDD; cd00054; EGF_CA; 1.
DR   CDD; cd00112; LDLa; 7.
DR   Gene3D; 2.10.25.10; Laminin; 3.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   PANTHER; PTHR46513:SF13; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF14670; FXa_inhibition; 2.
DR   Pfam; PF00057; Ldl_recept_a; 7.
DR   Pfam; PF00058; Ldl_recept_b; 10.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00181; EGF; 6.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00192; LDLa; 8.
DR   SMART; SM00135; LY; 20.
DR   SUPFAM; SSF57196; EGF/Laminin; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF57424; LDL receptor-like module; 7.
DR   SUPFAM; SSF63825; YWTD domain; 4.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS01209; LDLRA_1; 4.
DR   PROSITE; PS50068; LDLRA_2; 8.
DR   PROSITE; PS51120; LDLRB; 15.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW   Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   TRANSMEM        2001..2024
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          707..722
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS01186"
FT   REPEAT          769..811
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          812..854
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          855..898
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          899..941
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1083..1125
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1126..1168
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1169..1212
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1213..1254
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1387..1429
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1430..1472
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1473..1516
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1517..1558
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1692..1735
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1736..1778
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1779..1822
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REGION          33..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          200..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..79
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        313..328
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        364..379
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        385..397
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        392..410
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        404..419
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        424..436
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        431..449
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        443..458
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        493..508
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        515..527
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        522..540
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        534..549
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        560..572
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        567..585
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        579..594
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        624..639
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   2118 AA;  239677 MW;  BCDFFF22FDB696A5 CRC64;
     MRRCMFGPSR CVCAFKSLRH LFQSSLQDYL QSPSDTAEVT QTLCNDDDDD DNDDDEDYND
     DDDDNNDDDD DDDDDDDVHG DYGYPTTTWH GLTDLESKAE YGSASKQLLI PNHVRDYVGF
     YHQRQERLKP QLRSAGGITK EFHTSSPKSG DSDKYHESED HANYDDYVIH PSDTPSHDIS
     DDDYFVPELS HYPHEIFTTE PLQQQTSHEV GQGFNPGESA RHRDVGARSG SRTDLYGVRE
     SGDRREMTRG REGYMNMLHT KQKVFRPHVS LVHDETRLAS PNDGYRRDCP NICGEMQWQC
     ATKCNCIHAN ERCDKEPQCE DGSDEYDCDV VGDMMSKLQR ECEQTGMHVM CPKTYRCINK
     EWLCDGDDDC GDYSDETHCG ERINCTEDQF ECANGFCIPK QWLCDGENDC KDFSDEGHCN
     RTSCSNEHFT CNDGYCVSIA FRCDGERDCN DNSDEYKCPA VINSCPEGEF KCRGGLGGAG
     GPSGQCVLNR FLCDGDNDCG DWSDEENCPQ KPSQCTSSEL KCADGTCIPK RWKCDKEQDC
     DGGEDEHDCG NMNSSLHSSC GTDEFTCNNG RCILRTWLCD GYPDCSSAED EVECHLQCES
     GQFLCPAKKN ITNLKICVHQ KHVCDGQNDC PFGEDEINCP HYRDCESDAK CEQLCITTAK
     GRKECACRLG FLMHKNKQNC TDIDECQYLS SPVCSQKCEN TYGSFVCSCE RGYVLRPDLR
     TCKALGGAMT LIVANRWDIR RVTLSNNRYA ALVKGLHNAI ALDYHFKKGI LFWSDVSTDV
     IKTVYMNGTR VRDVIKWGLE APGGVAVDWI HDLLFWTDSG TRRVEVSNFQ GNLRSVIVSN
     DLDKPRAIVV HPGEAMVFWT DWGPNPKIER AYMDGSQRQI IINKGVTWPN GLAIDYPSNK
     LYWADAKQHA IECSNFDGSE RIKILSTHLP HPFAITIFED TMYWTDWNTK TVSAANKITG
     KGFRSVHENF HFPMDIHAYH PARQPEYPDR CQKDRRGLRG GCSHFCLPNK NSRRCGCPIG
     LSLKDDGKTC KSAPEKLVLV ARRKDIRLRQ IHAKSSTYND VDMIIPLDNL KHAVALDWTS
     DSDTIYWTDV EKSSINKAYL NGSHQQKVIH SNLVSPAGLA LDWLTDKLYW TDPSTNRIEV
     ATSNGKIRTL LIWDLLDKPR DIVVNPIEGL MFWSDWGDRP MIECAHMDGK KRRVVTSENL
     KWPNGLAIDY EQQRLYFVDG GTKSLEYMNF DGSERKTLLG GLGHPFGLDV SESRVYWTDW
     DLKAALSADK QTGKNMTTVI ANSSDLMDIS VFHRYRKRIS HACANDNGGC SHLCLLNPIS
     YSCACPVGIT IQPDNRTCSS GPSKYIIFAH RVDIRQISMD FDHLIDVVLP LPPISNAVAL
     DVDRKTGQIY WSDIVDSLIM SSSPDGLNVN RIIYESLDSP DGLVIDSVGR TLYWADAGRH
     TVEVATLDGR YRHLIAWKDL ESPRGLALDY EAGFLFWTDW GHYRKIERAY MDGENRQRIV
     TSNLLWPNGL SLDLKAKRIY WVDAKLKVID SCDYDGNQRK LIMSALHHPY ALALTDEFIY
     WTDWKSKALH MADRNNVSDK RDVMTNIDGL MDIKVISTNE KLPSNACGEN NGGCSQLCLR
     NPSGYTCKCG IGLKLINGNS TECEYLPEDY LLIALRSGIG LISLTTPDLM DVVLPIPGVH
     GVVVLDYHYR RNWLYIADVN LDIIRRVSLK NLTESKVIIN TKLATPNGIA VDWIADNIYW
     SDSDHRIIEV ARLDGSCRKS ILSDDMGDPR SLIVHPKRGY LFWSDWDTPS RIERCLLDGS
     NRTILVGNNL GFPTGLTIDF ENRRLLWADA LEDNIGQVDF NGKHRTVIIP YASHPFGLTM
     FENSIFWTDW YNKSVYRAYR EGRSFSQPVE IRDSLSGALD IRAVSLKRQL QEWNQCAQDN
     GGCSHLCLFR GLDYVCACPD QIDHSRECST SPKFYVPPQQ RLDENLADYT DEVTESDNPM
     LTEDDFGDDY RIKKSSRRET LILIAIGIVI ILLVISVTAI IYLVHNSKRT KSKRHKRGGS
     SRSVLTFSNP NYNVDGTPIE PKTTIWKRFK SDRIHERVYE ERSLTTETAS SSLFVPTPSP
     ATSPSVKKIQ LSTLSTIA
//
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