ID A0A1A9W264_9MUSC Unreviewed; 1791 AA.
AC A0A1A9W264;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 13-SEP-2023, entry version 34.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
OS Glossina brevipalpis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI003659-PA, ECO:0000313|Proteomes:UP000091820};
RN [1] {ECO:0000313|Proteomes:UP000091820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GBRI003659-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI003659-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 37001.A0A1A9W264; -.
DR EnsemblMetazoa; GBRI003659-RA; GBRI003659-PA; GBRI003659.
DR VEuPathDB; VectorBase:GBRI003659; -.
DR OrthoDB; 2916834at2759; -.
DR Proteomes; UP000091820; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF7; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 436..623
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 94..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1545..1571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1593..1644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 603..630
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 96..111
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1593..1641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1791 AA; 196443 MW; EF98CA995C57DF82 CRC64;
MLKTIKLLNQ SRGLITYGCV AIHESKLNAG SWEDSLPSAL NQNNNINPLA VQPSTHHPNN
GNNVTTTTAQ LHNISILKRP EVRGGLQTLI IPQHSQQPHH HHHHHHHHIH TSAISRCSEA
AQQQQQQLPS GAASVKLSGN TIAGGSFNAN GGSSAVGVTS SASATSTAPN SAGVQKHLED
SWCSAERGEH TPTEAHNKSP NPSISSEDEE LAHEEKANSS ATSSLSATNQ RNSQLRSTFN
RAKQHLSFDK WRSPGNANNC AADNSTNSSN NSAGGSGTLT RRASTTTCSI MPTAHQPSRE
DITTPGETPG GRLQRWFSIK RGSSHQYDVG GRDGRQSTSS SIDYTDTVCD GTSHMSVTQK
LTNSAHTTKS ACKMPGVPEN EDDETSSLTA STTRFDLDLM IPPGSRANGT ARTTHNRLMQ
PMLPPAPPGL SQQQLKRRHI VAAIVHSENS YVATLQRLVN DYKKPLEDSN PPILSVNKIG
TLFHRLPEIL QSHQLFRIAL AECVRNWDRD EKLGDCFVGA FSKPRILEIY SGFINNFSAA
MELAKMEEKR KSALADFFKV KQISAHDRLS FFGLMVKPVQ RFPQFILFLQ DLLKYTPQGH
HDRMSLQLAL TQLELLAEML NERKREAEQY QGFKEMLGHI SGTFNTRSLA STENNRPRYL
LREDNVTHME FNQAGFIVKS KQRRLLLLND KVICVSVAPK QSHDFGATEK LTFKWMYPVT
DVEIVDNSTS ATLSRILTAG LNRGGSLKSN SSSCNNYSSN TLPANTSSSS PTVYQNASFD
SSTAALLTSG ADNLCNEMSN LMYDYEVVSR INDLVGSLKG TYKELNTNIT RNVMNSIQSS
IQRKNEEMAW VDSCCLQLVA RNKSGKEENF TFQTVNPNVK KEWVTELRLA QLALDANNSP
AWETTSTDPI ATSSLAYEQQ QQMQLVQRQS NKMPLFVKAM PILKSQHQTE VRCGCYYSIA
NDSKMSGNAR RRHKQLNYLW VCTSDGSVSH ITVFSQHIQQ AGNLRDVSSF DVTDCQITAM
EFVKGLENCK TREEHNSLLS DLIWMGTDTQ KILIYSAKNP EQEEQLSCCT VTGAVMRILY
HFDTVYVALS SATMLIYRRA YDGVWMLKEP QIVVLGESSL SVPSLLPINM NIYAACANRV
YVLNALNGEI QKSFEVHHGA NQQVNLMAHS GIGLWISLKN STMLCLYHTE TFKHLQDINI
ASSVLRSDGK KEQAVNNSAI YVTALMACKG LLWVGTNVGI AVTIPLPRLE GVPIISGGIS
MSCHAHFGPI TFLLPLVSKV YPCYKPSTNQ SMTNALNTTA EPVVPSMGDD LQLPAIDADP
KKIAEAELDE SAVVLRRDLP KEEVGSGCGS PSALMLRELS AEGVDSATSS PRCSKLDKQI
SLDQSFSAKI RASLANSPAF HRKRFRDLSS ESARMSKTLP RGLGSPGYYN LGLNSNTSTL
NHSEHGYCDV YGLYGKLIFV KEDYDAAEGT QGNLMDMMYE GMRRSDPELA AIPGRVSTLD
RRLRMKASRP RSLDLSNWSV DSKSSSLYTS SGSEESMGIR LFGGRSVSRN SSSASHKTSG
NGSDLGNISE NGLMTSADIH STPKSEEGFK LMQQHKQTGT NLPTPATSST PPPAAATATL
KRKQKQNAKQ QQQQQADGPR TIITLTGGRG YWRHVWYNNA NSPGHKSSSS SSSLSSGSST
PLIANSNDAH IEFVWQRKVT PLTTATATTK TTQSVAATNA AVNVYLQPPI NLTTLERRGR
VRFRGSFVMR ERNSVSPLST SPSMSGCGVG MGVGSLRRLT KLKRGGSLKE F
//
