ID A0A1A9W2G5_9MUSC Unreviewed; 899 AA.
AC A0A1A9W2G5;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Peptidase M28 domain-containing protein {ECO:0000259|Pfam:PF04389};
OS Glossina brevipalpis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI003962-PA, ECO:0000313|Proteomes:UP000091820};
RN [1] {ECO:0000313|Proteomes:UP000091820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GBRI003962-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI003962-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family.
CC {ECO:0000256|ARBA:ARBA00010918}.
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DR AlphaFoldDB; A0A1A9W2G5; -.
DR STRING; 37001.A0A1A9W2G5; -.
DR EnsemblMetazoa; GBRI003962-RA; GBRI003962-PA; GBRI003962.
DR VEuPathDB; VectorBase:GBRI003962; -.
DR OrthoDB; 277019at2759; -.
DR Proteomes; UP000091820; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03875; M28_Fxna_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR048024; Fxna-like_M28_dom.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12147:SF26; ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1; 1.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 407..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 174..367
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 899 AA; 102225 MW; 3CF4C1E44CD29C3D CRC64;
MQLDKTPSSL HSLLRSRKRR ELKIWDGEEE EEDEMLIVEP KPRRVFHLTE EKSARISLKC
APFFIAFWAV LYLAIVRTQI TNLPKPLYRA DEHSNPESFI AERAEITLIN LTSIGPRVVG
SIANEVTAIK FLLNEIGKIR KEASDFFEFE VEIQEATGNY VHWSMINMYQ SIQNVIIKIS
AKNSNSENYV LINSHYDTVP TSPGAGDDGS MVAIMLEVMR VISKSKGPLE HPIVFLFNGA
EENPLQASHA FITQHKWAKN CKALINLDAA GNGGREILFQ SGPQHPWLMK YYRQVSHPFA
TCSAEEIFQA GLIPSDTDFR IFRDFGGVPG YDMAFITNGY VYHTEHDKVN VLPKGSLQHT
GDNVLTLAKC LANAQELNDS SQHSEGHVVF FDFLGSFMIF YTESVGIILN IIVCLIAIIA
IGLSLYLMAV DSAISLKSML SSFAASFAVQ VATLVAAGGL AFLNALFIDA IGSAMSWYSQ
KWIFMGLYFC PLFFAMGFLP ACYLSKSRKG KLYLGFHIQL LMHSHCLFLI VVTIVLTCFG
IRSAYMLMMA VLFYALALII NLITKCYRSV YWFALIMTVC QILPFLYYTS LTHIIYDAMV
PMAGRSGSSS NPEIFMCGIA IFFTILFAGF IISLLQFFQK ARVLFTTFLI VALVFIIIAL
TPLGFPYKDK TASQRHALIH AHRIIHDADK TIRVKESGIY VFPQDRNVKI LNEHIESIGQ
RHTVSDYCDK EMFCGMPFYN HRWYKARDFS FWIPIEEDPH IPDEPPILNL LSSNQFTDPF
KTNYEFELSG PDHMTIFIGV KGQGRILDWS FNDTMIRENW EPPYFIYFSW GTNRAALKFT
ILVEKTAETL NKPILEIGIG GHWTHNEKSR PRKYQQFVNS LPDYSTLTDW VATYESWIF
//
