ID   A0A1A9W4K5_9MUSC        Unreviewed;       769 AA.
AC   A0A1A9W4K5;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=VPS9 domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Glossina brevipalpis.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI006087-PA, ECO:0000313|Proteomes:UP000091820};
RN   [1] {ECO:0000313|Proteomes:UP000091820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GBRI006087-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI006087-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A1A9W4K5; -.
DR   STRING; 37001.A0A1A9W4K5; -.
DR   EnsemblMetazoa; GBRI006087-RA; GBRI006087-PA; GBRI006087.
DR   VEuPathDB; VectorBase:GBRI006087; -.
DR   OrthoDB; 20678at2759; -.
DR   Proteomes; UP000091820; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 1.10.246.120; -; 1.
DR   Gene3D; 1.20.5.4770; -; 1.
DR   Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR   InterPro; IPR041545; DUF5601.
DR   InterPro; IPR003123; VPS9.
DR   InterPro; IPR045046; Vps9-like.
DR   InterPro; IPR037191; VPS9_dom_sf.
DR   InterPro; IPR002653; Znf_A20.
DR   PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23101:SF122; RAB5 GDP_GTP EXCHANGE FACTOR; 1.
DR   Pfam; PF18151; DUF5601; 1.
DR   Pfam; PF02204; VPS9; 1.
DR   Pfam; PF01754; zf-A20; 1.
DR   SMART; SM00167; VPS9; 1.
DR   SMART; SM00259; ZnF_A20; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF109993; VPS9 domain; 1.
DR   PROSITE; PS51205; VPS9; 1.
DR   PROSITE; PS51036; ZF_A20; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          12..46
FT                   /note="A20-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51036"
FT   DOMAIN          258..401
FT                   /note="VPS9"
FT                   /evidence="ECO:0000259|PROSITE:PS51205"
FT   REGION          679..724
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        679..694
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        695..709
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   769 AA;  85666 MW;  0712422EA620FE99 CRC64;
     MSTTRIPQLR MGQHELKCKQ GCGFYAYWQF DGLCSKCFRE RNDKKKKCKQ KTKKSKLELI
     HFINFKVVAL VTSSSAEPEH ASPATCSQSN QNKILAGSKK SINVTESGAL IKKKSLMPAV
     LQKTSQTLKR QTRLKSEHSQ SKVIQQRNYI VDPTESQFIS LLRQLRIPDD GKRKLKTEIQ
     RLDNAIRTYM HSTATKNVDE LSELVQNAYT KLSDIVHTDQ KFQIASNEDR ESAIDFFEKV
     VMTQNHELLF SPYFTADEEN DVKIQERIRQ LSWITAKHLA CSIDEVNAES RELVYNAITE
     LVAIDSFYSP QEKLECTVKC CRHIFELLKH SVGGPASADE FLPALIFVVL KANPVRLHSN
     INFVTRFTNA SRLMSGEGGY YFTNLCCAMS FIENLTAESL GIDAKEFDLL MSGSKPISTP
     WESALLACES LHLISENMKR MDMLKTRNQN ITKGIDQFCL DLEEFQREIT AKVDAVIVKA
     PLTILPIKTP KFLIAEARAV LANDPSKIIA KTVTEIGGCG HYQSNLLNAV DTSFNDSPLS
     GKASGGSKVL PLPLKPQKVT TPKKLNSSDD SVLNTSTASR TLSLNETATA IGRLSPLPPS
     TIQSNVDMLF ASPIFNYAPF DNVSLLDETS DSTDDLLLPT DYRGGLTNIN YDFDLSDHSN
     NSVDEELKLN LAEFDPLLKS DTPSTSLPNR IRQHDSSFVK TEEKSLLDSD SPANESSLPS
     PLKPTVTDYR GFSNCEIPSI SCNTGDFSSL NHAINSETNG MVNNDNSKE
//