ID   A0A1A9W573_9MUSC        Unreviewed;       895 AA.
AC   A0A1A9W573;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Ionotropic glutamate receptor C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Glossina brevipalpis.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI006803-PA, ECO:0000313|Proteomes:UP000091820};
RN   [1] {ECO:0000313|Proteomes:UP000091820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GBRI006803-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI006803-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC       family. {ECO:0000256|ARBA:ARBA00008685}.
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DR   AlphaFoldDB; A0A1A9W573; -.
DR   STRING; 37001.A0A1A9W573; -.
DR   EnsemblMetazoa; GBRI006803-RA; GBRI006803-PA; GBRI006803.
DR   VEuPathDB; VectorBase:GBRI006803; -.
DR   OrthoDB; 3108846at2759; -.
DR   Proteomes; UP000091820; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IEA:UniProt.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR   InterPro; IPR019594; Glu/Gly-bd.
DR   InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR   InterPro; IPR001320; Iontro_rcpt_C.
DR   PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR   PANTHER; PTHR18966:SF363; IONOTROPIC RECEPTOR 93A; 1.
DR   Pfam; PF00060; Lig_chan; 1.
DR   Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        616..637
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        681..703
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          492..599
FT                   /note="Ionotropic glutamate receptor L-glutamate and
FT                   glycine-binding"
FT                   /evidence="ECO:0000259|Pfam:PF10613"
FT   DOMAIN          613..876
FT                   /note="Ionotropic glutamate receptor C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00060"
SQ   SEQUENCE   895 AA;  104564 MW;  6F22D02ECA53FCD1 CRC64;
     MPYDSLCFCY VIHNTAVYMY AKFKPTPPRF FDYRSNSSIE KNDLSNQSHR NLSSGQYSDF
     TSFLNANATL AVIVDQTYMQ HQTNEFILNH FQKILNNAVH ENLKYGGINF KYFTWTGIRL
     KKGKEKFEAL KYISLPLITD TLAALTVMDC DNTWNFFEDM KTSNILVIAL TNAECPRLPI
     NQALMLLFVC LFMVKLRIPY VNHGQEFPQM ILDAKMQRIL NWQTAIVIMD QVLINENNHL
     TSSIMHESIK RNIEPISIVL YSIDDQLKRQ KKRSAIRDIL QLFSGRSQSK QQFMIFSKFY
     EDIIEIAENM QMFHVSNQWL FFIFEDTEKD FDVLSVTQNL EEGANIAFAL NETRHECQIS
     LNCTMSELSK ALVNSISQLT LEEQSLYGAV SDEEWEYIRY TKEEQQNEIL NYMRKYMKDH
     TSCSSCARWR IITALTWGKN QEHQKIIHRR EISENRNKNF EFIDVGYWSP TLGVIAYESL
     FPHIVHHFRN ITLDILTIHN PPWQIIKKDT KGTIIEYSGI VMEIVKELSR MLNFTYKLHD
     ANTLEFEAYE NQNETVITKI NLYFMAAVAA TINDPDKKAF NFTTPISIQR YSFLTRKPEE
     VSRIYLFTAP FTLETWVSLI AVIFITAPIL YLVNCLVPTL HLKVQGFCTL RNCFWYIYGG
     LLQQGGMYLP KADSGRLIIG VWWIVVIVLV TTYCGNLVAF LTFPRFQPGF DYLHQLFVDQ
     SFKELGLRNN TFFESYAAIS SRLDFQKYLN HAIIYNNSVQ ENLEAVKSGD RINVDWRINL
     QLIIQNHFEK EKECTLSMSK ESFLDEQIGL IIPVDSPYLD LINTQIYRLY QMGFIERWHQ
     TNLPSMNKCN GKGLLRYITN HKVNLDDMQG CFLVLLTVKN GKNAKRSNIF LVYMR
//