ID   A0A1A9W595_9MUSC        Unreviewed;      1409 AA.
AC   A0A1A9W595;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Probable ATP-dependent RNA helicase spindle-E {ECO:0000256|ARBA:ARBA00013352};
DE   AltName: Full=Homeless {ECO:0000256|ARBA:ARBA00031299};
OS   Glossina brevipalpis.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI006849-PA, ECO:0000313|Proteomes:UP000091820};
RN   [1] {ECO:0000313|Proteomes:UP000091820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GBRI006849-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI006849-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000256|ARBA:ARBA00008792}.
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DR   STRING; 37001.A0A1A9W595; -.
DR   EnsemblMetazoa; GBRI006849-RA; GBRI006849-PA; GBRI006849.
DR   VEuPathDB; VectorBase:GBRI006849; -.
DR   OrthoDB; 21853at2759; -.
DR   Proteomes; UP000091820; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 2.30.30.140; -; 1.
DR   Gene3D; 2.40.50.90; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR002999; Tudor.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF113; ATP-DEPENDENT RNA HELICASE TDRD9; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00567; TUDOR; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50304; TUDOR; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW   Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT   DOMAIN          126..270
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          316..503
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          910..973
FT                   /note="Tudor"
FT                   /evidence="ECO:0000259|PROSITE:PS50304"
SQ   SEQUENCE   1409 AA;  161982 MW;  C1328AE1DAF7D320 CRC64;
     MDEIEDFFNI SKDFVPRSAP PERPRYEVAS TSKTASQLLK RRISEEDKNV LKKFCKKEES
     KSKLLISNQD PEVANFSIDD LREKTEHVDV DGGVYDRYVF DLNRDDSLPI HDVKEKIVDA
     IRSNPVVPQY ILDEAYRRRE YCRIICTQPR RIAAISIAKR VCSERKWEEG TVVGYQVGLH
     ANMSDDTHLL YCTTGVLLQK LIREKSMFPY THVILDEVHE RDQDMDFLLI IVRRLLVTNS
     KNVKIILMSA TMDVTEFSQY FKIFNKPAPV IQSDTRRLYH VKDFYLSDID RINTQKAAVD
     FDNPGITLEM YNLALKLIIV IDNIEKQEAN YNPNTCLDAN RIAILIFLPG INEIDQMYNK
     LQRLNEADLK KTKLYPIRLH SIISPEEQVK IFRRPPSGFR KVILATNIAE SSITVPDIKY
     VIDFCLTKIL ITDTSTNFTA LQLHWASRAS CRQRSGRAGR VMNGRKYLDE FSKPEMLRCP
     LENVVLKAKL LDMGSPITVL GLSMDPPNLS DIQYTITTLK EIGALYKYAN GIYSIDDGDI
     SFVGRVMAMM PLDVRLTRLI ILGWVFGALE ESIIIAAGLS VRSIFSTQHY NRENQISAFI
     QKLKWADGSG SDLIAILCAY NEWASLNQVK EEHNEKYEHS WAGKKFINLR SIREMHLLIL
     ELKERLALFG INKNCTYRIS SSLDWEKAII LKIIISGAFY PNYFTRSRMT RPDKERTIYH
     TLCDHDPCNT VMLSNFEARH IGELYVGQIK KIFRDVAIQP EQIDVRFQPG SEKVFIVFKD
     RIIGGNDNED EQIKMPGSVH INVYKALRLR SLIGRYQINV MGSKEGEYAE GCGLGNICNG
     VFKPIDRMVQ HVALVVLPSV FQKNIIGYIT HIETCSKFYF QPISETQRLS EIHDLLNDPK
     ELQNCRFLNA AEIRNGMFLS ARFEEKFHRA QVLNVIHISR QHVQFKVYFI DFGNISVVKL
     DDLRHFSNDS KHLSDIPPRL YQCRLALVEP SAVISPNEKW VDDAMMLMQE HADAGPTEIE
     VYSLVNAIAN VIVKKEDSSL NEILVEKGLA RTSDENLVSK TDHDFRLRKQ SVANRFLDDE
     HSRQNAEYLR SLHPELEPNI QSPPKELCTR TLNLRGPFSP IETNIYSAIN IGCCKSVQTE
     RDSVNFMLID PDPKDAYERL IVAAGITESQ NGENLVVRGT TLMPNIHGFC ALMTLLFCPT
     MQIKCNKGKT KYVSIIAGLG YDEETLNSLY REHDIVLNLD VDLLSDDIEL INQIRYSMDT
     VLFTEPDQER PAIHPKECEN LTVKIQKLIF RLLSKNRKYT DITVGPNDNK WQTFAKETVT
     DTTDLYGKRS LFPALAAPHL FDEKYNDIHS LISHCKELHY LRQFDGNIKP ITCLLCQEPL
     ENVTYLRIHL LSQLHRDREH QIRFKAPPM
//