ID   A0A1A9WA69_9MUSC        Unreviewed;       583 AA.
AC   A0A1A9WA69;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=Dishevelled {ECO:0008006|Google:ProtNLM};
OS   Glossina brevipalpis.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI011969-PA, ECO:0000313|Proteomes:UP000091820};
RN   [1] {ECO:0000313|Proteomes:UP000091820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GBRI011969-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI011969-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DSH family. {ECO:0000256|ARBA:ARBA00008735}.
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DR   AlphaFoldDB; A0A1A9WA69; -.
DR   STRING; 37001.A0A1A9WA69; -.
DR   EnsemblMetazoa; GBRI011969-RA; GBRI011969-PA; GBRI011969.
DR   VEuPathDB; VectorBase:GBRI011969; -.
DR   OrthoDB; 2910598at2759; -.
DR   Proteomes; UP000091820; Unassembled WGS sequence.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd04438; DEP_dishevelled; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.40.240.130; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR008339; Dishevelled_fam.
DR   InterPro; IPR003351; Dishevelled_protein_dom.
DR   InterPro; IPR001158; DIX.
DR   InterPro; IPR038207; DIX_dom_sf.
DR   InterPro; IPR015506; Dsh/Dvl-rel.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10878; SEGMENT POLARITY PROTEIN DISHEVELLED; 1.
DR   PANTHER; PTHR10878:SF25; SEGMENT POLARITY PROTEIN DISHEVELLED; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF02377; Dishevelled; 1.
DR   Pfam; PF00778; DIX; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   PRINTS; PR01760; DISHEVELLED.
DR   SMART; SM00021; DAX; 1.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50841; DIX; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW   ProRule:PRU00069}.
FT   DOMAIN          13..96
FT                   /note="DIX"
FT                   /evidence="ECO:0000259|PROSITE:PS50841"
FT   DOMAIN          230..302
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          383..457
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   REGION          99..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          192..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          545..583
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   583 AA;  63968 MW;  7F364FEE69C4B4D9 CRC64;
     MDADKNSGGG GGGQETKVIY HIDDETTPYL VKIPIPSSQV TLRDFKMVLN KQNNNYKYFF
     KSMDADFGVV KEEIAEDSTI LPCFNGRVVS WLVSADGTNQ SDNCSEVPTS ECGDTRPAGR
     LPQPLQQQQK MVGGMVGMGT GGVISNPMMQ PPPPLTYQSA SVLSSDLDST SLFGTESEIT
     LDRDLTDYSS VQRLQVRKKP QRRKKRAPSM SRTSSYSSIT DSTMSLNIIT VNINMEAVNF
     LGISIVGQSN RGGDGGIYVG SIMKGGAVAL DGRIEPGDMI LQVNDVNFEN MTNDEAVRVL
     REVVQKPGPI KLVVAKCWDP NPKGYFTIPR TEPVRPIDPG AWVAHTQALT SHDSIIHPDI
     PEPIKERLDQ NNLEEIVKAM IKPDSGLEIR DRMWLKITIP NAFIGADAVN WVLENVEDVQ
     DRREARRIVS AMLRNNYIKH TVNKLTFSEQ CYYVVNDDRN PLQCRSNLSH ADTESITSDI
     GPLPNPPIYM PYSATYNPSH GYQPIQYGIT ERHGLSSGSS SSDVLTSKDI SASQSDITSV
     IHQTNQMTIG HHGSNKSSGS SNRGGGGGGN CNEQDSIQFN YVL
//