ID A0A1A9WD06_9MUSC Unreviewed; 3705 AA.
AC A0A1A9WD06;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Cubilin {ECO:0008006|Google:ProtNLM};
OS Glossina brevipalpis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI015051-PA, ECO:0000313|Proteomes:UP000091820};
RN [1] {ECO:0000313|Proteomes:UP000091820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GBRI015051-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI015051-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 37001.A0A1A9WD06; -.
DR EnsemblMetazoa; GBRI015051-RA; GBRI015051-PA; GBRI015051.
DR VEuPathDB; VectorBase:GBRI015051; -.
DR OrthoDB; 2917265at2759; -.
DR Proteomes; UP000091820; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 17.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 22.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 17.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07645; EGF_CA; 3.
DR SMART; SM00042; CUB; 20.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 21.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01180; CUB; 22.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 157..195
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 197..238
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 291..330
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 377..414
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 423..459
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 460..497
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 503..618
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 622..733
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 739..847
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 848..979
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1102..1212
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1216..1331
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1332..1445
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1447..1558
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1562..1674
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1675..1751
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1785..1895
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2007..2128
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2129..2247
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2250..2364
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2366..2487
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2493..2607
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2725..2841
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2844..2956
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3076..3188
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3191..3316
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3320..3460
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3573..3684
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 185..194
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 228..237
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 449..458
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 487..496
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 503..530
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 848..875
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 2725..2752
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 3076..3103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 3705 AA; 420731 MW; 715FCA40C921F937 CRC64;
MSLRLKLEKL FLNLPTFLLC ATIAFISISK AEYPKQPKIL VNDGTLLLEA ARDCNITLRL
SRDALLYVNN IDVMEKIRHR YTSSSLDTES KDFDIVTTEQ IKQNMLLLND DLRSFAASLL
SVQNNTRLLL QSRVLRRYLG RLRRLNGRLV AIERELLNNE CTQIPEPCKN GGTCYDGYKD
FYCECTEGWT GKTCEQDIDE CYTLAGTELG CQNNALCVNT PGSYSCSCVK GFAGLHCRSR
SVVCQSGHTF TLCGHGTCIS ANNNQGFTCL CDQGWSKAKG NDSALSPCTV DVNECEESRN
PCHSQCINLP GSFKCSACPV GYTGNGLTCQ DIDECALNNG GCSSLPKVKC INTEGSYVCG
HCPRGWIGDG HTCNPVLSNS CDNENICHPR AKCQYISGVN TCTCPTGMFG HGFGAGGCHN
NPTTDLCENH LCKNNGTCLV TGRGTSCLCL DGYSGALCET ADACHPNPCA NAALCRVMPN
DKFQCSCPRG STGKRCEIMR SVCGAILNRK TGSLRYPMDG SSGYADSERC AWIVRTDIGY
ILNVTFSDFD LEMAEDCSRD WLQIHDGISL AAQLIGRFCG NTLPLGGNFL SSHEQLFFWF
RSDNDTNARG FNMSWTSIEH TCGETINLNL GDAGVISSPG YPGKTPIKRE CEWSLNAPYG
NRLVLRIYEI NLGTKPNCTG DALKIYDGGV LIKSFCETAK PKPLRISSNT ALIHYHTDVL
RADSSFQLHY EVEAGVPNCG GIFTESSGLI ISAKDQPVCL YLIQQPPGIQ IKLEFLDYHY
GQVANCLLHV IEVFNGKTDQ DSLLLRLCSP SKPEPIVTES NYMLILHKNL LHNSESEFIF
KLKYSRICNA KYFGPDSGRI STPNYPEPYF DDIICTYEIY GPANTIIVAN FTDIDISESN
EYFLQNKDVV DDTNRNLSSS LEGDTLTYMD VHLSSTLRKR YYKGSPMRLV SANNRMKIVF
YATKNTRRAR GFHVEYSFDT LPCGGVYTDN ETSFDVTVQE RNVIINDDND GFVKGKLVCE
WIVEAPVGRH IQLYLNYLPM GENIPLLIFG ESASGQHLLF NITRERRVSE VFLYDSLTIQ
GLVSATYHIS ANVTFLNSLA ECGGHFTASY GIIKSPSWPF SYPPNMACTW EIVASTGHQI
ELRVQNFTLE NTCKGDVLEI RNGRYSSSPL IGRYCGSDIP SRITSFTNSL FVKFTSDRYI
EKQGFHITWS QTTTGCGGKL TSYMGSITLP HYDYQSDYQE QCNWQIIVSQ GSIIELSLFQ
VMCHDKYLKI YDGPSTLSPQ MKFICSDFTS VSTDEKFLSS TNQVLVIYSL ASSSQPFIDG
HMKFILDYIT KCGVIIDRVQ GVIESPNFPD SYPPNQNCLW DIKGGRNNKI KLLFSHINLE
NDMSLSCDYD YLEIIDMENE EVLKQKRICT FQYEPIQTVG NRVKLKFVSD YSQNHGGFRV
EYMRTGCSQT LVKSVGSIIS PNQPYSLDLD CEWYIETNPG TKIYLTVEEL YLESENNDCE
EDAFIVAENK DYKFPLLKEC QIEKTILKVT SPSNRMYISF RTSAKRTRKY LKAYYHSEYA
ECGGLYRANS GYITSPNYPA NYTRSIQCFW YIRIPEAYAI ELRFEDFDIS KSDFCNNASL
TISKMNNTQE LSRRILCGMQ KHSVKRIHGQ EVRLMLRVNN TNSYAKFFVH YRKECGGNIT
DSSGYLLSKA NEECVWEVSL PEGSQLSVNI LQLDCYCKKS NPNASNCDDG LGFTGNYFEE
IDTGNFSFQY CEQHLSNLIF NGPKVYVVAR GINFHAGYDL TQNSCGGSLT SLRGSLVSPG
YPNSYPGDVE CIWEIQAAKG NSIVLNFLDV DLATSEFCNQ DFIEVRRSAT DSLIGLYCGK
QYPESMIQVY DKVLIRFRSA TGSTGNGFKM AWSHNNEFIN QTKGTIEALP LKAARNEEEG
FSWRVLVPRE TYISLEFLQY TGGLKLFDGY DNTGLQVEIP SLFPWRFVSS TNVLFLQTVN
MELEYFLLNW TTIEHKPLSQ NATNSKCFAD QFLISPARVN VSSPGYPHGY ENDLNCQWIY
KPELSTEHVV LALYQVKLEI SDKCNVDYLR VSTSVDLEQW HSEIRICNST DEIWKPFKII
HGRPYLKLEF VTDLSVNLTG FTSLVYTQCG SNLTDTVGFI PFRIHWYMTM RRICEWRISV
KPGKRVNLQF DFPSNVLQND RDCRSYALIY DGIDDHAPLL KPGKICSRQN STRLLMQSST
RHVMIKYNVN RTMGVPLLLW NLTYREFSEC NAEIKLTHEA SSVNITTPRY PDVPNPYTDC
NWIVIAPVGE TLKIEFLDHF SMNVRYCNKE YVEMFDGSTE LSPRIGRFCT RPSEKRTTGN
LLLIHYITNI AEPRNGFRAR LSLNKCGGTF TDARGYITSS GYPATDAYPA YSQCDYYLRS
PVGEVMKLEM EDLNIPYNST DNKNSDYLEI ADLNNVTLNA NMTYIYLYGN VTELPVYVID
SSLIRIRFHT FKKATNFRGF KMSYSRYANR QSCNYYMYFR EARFLINFNK PSSSGVTCRW
KINVPKGQRI KLEFLNLQDL KDQSLIRSPR FSVYNDFDSI SEIINFDANT YNANYTIQSS
DNTMLLKVFT PYIQSSLKPI TARYSSHNLS ICPRDIGEGD EDGEISLSDS EPEFNTNYYC
RIRIRLNGQE TMILTLKALY VHSERNHLYP LTIRDSTGLT LYQENITDIA IPMQMSSDGI
AAIIIFSSRF VSLHKLIMQY RRFPCGSVME LNNDAIINYP QFSASDASEI VCVWTLRKYF
REDSLEYRLI GNFSFSDSCD EEYVEIFVGA LRKSKPALRI CRDNAAEFES FPLKNRLNHV
TYNSQNFKAQ ANSFRIRVTR DLGCGSKSIV MSNQQLAVSK DTYKNNEECL WEFYTLPGYY
FKLNFNGRFF IEDSVNCTKD YLEIQRFAEG LWLPEIRLCG REVYSQYNLT ANEIQIIFHT
DKAITGDGFT LEVQADCLVA FNVTSEVQTV KNPPSVNGAN SGHCEYTFFA AKKDQLFSVR
IFMEEDSPSH ISRFELQNKC RLGYFVPFKK FENQTEKTED RRCMGDFELR SYQYLRLSYE
ALTFMKFRIE FSYDNCGGNI THPSVIRSLK HETENTYANN MNCIWYITAP PEHSIAIRFK
YFITEERYDY VSIYTGPSIQ TDKMLSKLTG DHTKNPPTIV VDRNQAVVTA VSDSSSSKEG
FEAKIVFLTN CNERITLTDG NSPVTLTRDF KFNATTEYLC HYRITAPKGY QVRIDVRRIQ
LNGLDTDCNL PAAKCSAQCN YIEIFDGISN AKASMSKFCS AFTTNRTLIS SMEDVFMELN
ARFTGQYSFE IILSMEKSIC GDFLNYEFGE SEKLTLTFPP HSVESDKYPP NTHCHWRFKT
KNFLKIHIDY LHLQNTSQVT GKCVDYVQFK GYLVSPSVGF NINLKNLNFF STYQSSTVLC
GHVNDFNLTL SKTRNSISEI IFHSDESMED RGFQLTATQK ESCNITYSEL NGMVVYNNLR
FSEKFCEDII RVPDTHNLNL YLPPMIFKNN DCTQVHLKVL DFYTNRTLLE QCGNEYGYKR
LNTNTSAVRL LVGEFIAVHI SYVASDRTLP PGCGGKLQTT TGLFANPSYN ERNFSDCRWE
IEVPAPNFVK IFFPQFNMGT ITNCQWDYVQ IIDILPDGTE KLKNTYCGSD RPDHQRSMSN
RVAIIAKKSP NFDGTGWIIG YDLNSSDNLN ELMGNEGIRF DDPFG
//
