ID A0A1A9WFE7_9MUSC Unreviewed; 3960 AA.
AC A0A1A9WFE7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Dynein heavy chain 12, axonemal {ECO:0008006|Google:ProtNLM};
OS Glossina brevipalpis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI017688-PA, ECO:0000313|Proteomes:UP000091820};
RN [1] {ECO:0000313|Proteomes:UP000091820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GBRI017688-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI017688-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 37001.A0A1A9WFE7; -.
DR EnsemblMetazoa; GBRI017688-RA; GBRI017688-PA; GBRI017688.
DR VEuPathDB; VectorBase:GBRI017688; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000091820; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 678..1101
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1234..1560
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1732..1864
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2088..2172
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2244..2503
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2522..2865
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2892..3113
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3358..3471
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3507..3646
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3654..3956
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 2762..2803
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3960 AA; 456428 MW; F2CCEDFEFEC02560 CRC64;
MYTRKLENMH HPPSDVHRYD DEEYARNPLL RFHLVDVYER RHHTFLKYQA ARIKMQLCST
RLPAEPEVHL LPEWRYVDNL RQCVRQISVP KMLIKTENKM LNYAPQKLRE KFPDIMRSYM
KDVHQEFDRL MKIYSMKCIL MRPELADEDP DEFNLPKPNW YYKLPGRTDQ YPKYLQNRRR
ISRRLLILHL PVRAVLNTTE QDFPDSLVTF YPLIMNVTQG TFFGSGLREY ISYKTFLKYV
RQSLEEKMTY LRWNWYPKLI SVIRRTYKKK ALPIKTWPAI IRCMEGLINR QFNNLKQRTF
HELKTVCCNR RTIPLIKLHL TCYEDGIDID ISPSMDEILN VYETVVREIA VVGNKIEHIQ
GLIDPLFINQ GNEFLHVELN ENYISEFIVE LREIIRETYE PIMAYVESYQ NKYRGLYSEE
ERLELEEFLS EPHKFGEYFS KINVYFDYIN KLRCEPRREY FEMSIVNNQL AHTRLRQIAD
DRISRITEEI VQSHIKAEED ICDDFEYIKD RALEIPKTTE ELLANAEYMI YVKREKLFEL
RDRIQHCLAV GTNLMELTEM TQYHFNLTIK TINWLQDIND ICDTNASQQE NYKYLFEEHL
LEVILKLNAD IEEMIPKTTI INDMSDPDKF KEYYIILQNF MDQLKTMDDY VAWINKEEKL
FKMQKTEYPT LELLKTFVFP FCALMKACIQ WIRYYNVWMD GPFEYLEPKF VEQTTDDFLK
EFQKNQKYYR LKIKQDSIDN PPCKFKGQTE DPDPSNHPVP LRLCARMIQS IKDFTTGVFI
VNQMCHSALR KRHWKEMSEI AGFDLTPDAG TTLRKIINYR LDSKLDQFEI ISVGAIKELQ
LWNNLQSMIH EWDSRYFPTG PYKETGVQIL SSLDDIQAML DDHILKTLTM RGSAFMKPCA
EEVLAWYDKI MRVNDTLDQW GKVQANFLYL LPIFSSKDIV AQMPEEGRLF TIVEQTFTRN
MGMVLRQPLV METAPASGLL ESLQKAVELL DDITTGVSNY LEKKRLFFPR FFFLSNDEML
EILSETKDPL RVLPHLSKCF EGVDSLEFDQ AKNVLSMLSS DKELVPYVAI VSTAAAGGSV
EKWLLGVEGE MLKSVRDQME KSYHHYPTLK RIEWMCAWPQ MIVLCVSQIY WAANVHTSLR
KMSVNSHAVA DFFKELNADL KRTVELIRST KINNLNRITI KSLIVIDVHA KDVIEDLVKQ
KISSEYDFQW MSQLRYYWEE NDSWVRIINA TVHYANEYLG NSDRLVITPL TDRCYRTLVG
AYQLHLNGAP EGPAGTGKTE TTKDLAKALA VQCKVFNCSD GLDYKAMGKF FKGLASCGAW
ACFDEFNRIE VEVLSVVAQQ ILLIIQAVRA KAHKFMFENT ELTLNPACYV CITMNPGYAG
RSELPDNLKV LFRSVAMMVP DYAMIGEISL YSYGFVDARK LSVKIVTTYR LCSEQLSMQN
HYDYGMRAVK TVLSACGNIK KQFPNEVEDI LLLRSLIDVN LPKFMSFDIP LFEGIISDIF
PGITLPYIDY TLIEREFNHF CTEMILEPTE SFLIKVIQTY EMIIVRHGFM LVGEPLAGKS
KTLQILAKIL SSLKIKAPAK SPYYQHVLMG IMNPKSITMN QLYGSFDPVS YEWTDGLVAR
IYRDFAMTPT PDRKWVIFDG PVDAVWIENM NTVLDDNKKL CLTSGEVITM TKEMSMIFEV
MDLAQASPAT VSRCGMIYME PATLGWRSFA NCWLKKCDTR WAHEEGCAYV LSLLSWLIEP
CQEFVRKNCR QFIKPGEFNC LTTTFDLFDM CLFEAIEENP DDYQKNIEIY FQAATLFALG
WGVAGVLDTG SRDKFDAFLR KIWSDEDNVP EELGKLEITL PVEGILADYV YIFKQRGAWR
SWNELAKRMD VEDTPLGVQV PTIDTARYIH LLKMHILHKK RLLFVGPTGT GKSVYVQNYM
MSKLDTEIYE SAFMTFTVMI TANQTQDLLI SKLLKWKRGI YGPPRGKHSI LFVDDMNMPI
KEEYGAQPPL ELLRQYFDYG HVYDLKDSSK IFLHNIIFVS ACGLPGGSRQ DVYPRFLNHF
NIYSINTFSD DTMNRIFVNV LMNGFRRTGH GNDVFQVTNQ IVNSTQQIFK LIQAEMRATP
AKSHYIFNLR DIARVVTGCS LMRKETVNDK KIFTRLWYHE CMRVFYDRLV NDNDRQWLFD
KLNECVRVFF RDKLESVFEQ YCTEINGEST FTLEGANSIF FGVYFDEDSV PDERRYEEVP
SLATLHKLAV TSLDDYNSTR RSKMDIILFT FALQHLNRIC RIISIGGASA LLIGLGGSGR
QSLTKLATNM VQTSFFQPEI TKNYGPNDWH DDLKNVLKEA GGMDKHTVFL MTENQIKMEL
FLQDIDCLLN QGEVPNIYAI DEKQEILELV RLAAQGGNRN IDIAPLQVFA FFVNRCKRKL
HIVLSLSPIG DSLRTRVRLY PSLVNCCTID WYQSWPEEAL QMIAKISLED VNVPSNQTKQ
AIVETCQYFH TTANKVCADF CEATSRYIYL TNAYFLELIL SFQTVFGRKQ KEVMSAKMRY
IGGLETLASA AAAIAIMQKE LNALQPKLLA LAENSRKMMI EINTETIAAS AAADQVKKDE
EVASVQAEAA QVLKVDCEKD LAQAIPVLEE AIQALNTLKP ADITLVKSMK NPPAIIKLVM
AAVCVIKGIP PDRVADPASG KMVNDYWGPS KRVLGDLNFL QNLKDFDKDN INPDIMRRIR
KEFIPNKDFD PKIVAKASSA AKGLCQWIIA MDLYDNVAKV VAPKKAKLAA AEKEYADTMT
FLNEKRAMAA ALEAKVAKLN EDLERANIEM KRTQDEADLC QNKLIRAKSL IDGLGGEKSR
WTKAAEDLQN LYDHLPGDIL LSCGIIAYLS AVNYQYRNAC VEDWYKKCVK LKIPISDDYN
IIKALGVEIT IQSWNIYGLP NDVFSTENAI IAFNSSRYSL FIDPQGQANN WIKNMERKNR
LGMVKFNQAN YMKVIAEAME YGSPVIIENV LEELEVPLDP ILMRNTFMQG GQKYVSLGDN
IVPISSNFRL YMTSNLRNPH YLPETFNKVT IINFALTQSA LEDQLLSIVV AKERPDLQEL
RMSLTAEEAR NKAALVDAEN MILKTLTSSE GDILEDEGAI QILNESKALS LDIVAKQAAS
VETSAKIEAF RLNYKPVAVH SSILYYSITD LPNVDPMYQF SLNWYINLYK YSIETANKSK
ELARRIKFLL DAVTKNLYNN VCRSIFEKDK LLFSFILCAR ILLGNNQIQM RQMIHLLTSA
RENPNLPPNP NPKWITDIIW LNIVRLEELS ELKGFVNSFK SNLPAWELIY DHTEPQDQVY
PEPWNNKTTR FEKIIILKAL RPDKVFIAVQ RFIADEIGTQ FVTPPDFDIS KSFTESTALT
PLIFILSPGA DPLGSLLSYA EKMGYDETFQ SISLGQGQGP IAENLIKNAQ DLGYWVCLQN
CHLAASFMPR LEFLWENMDT FNTSPAFRLW LTSYPSPQFP VALLQNGVKM TNEPPTGLKE
NIMRSYNSEP INDPNFYNGV VYQDRAFTRL LFGICFFHAV VQERRKYGPL GWNIAYGFNE
SDLQISVLQL SMLLNQYEHV PYAALSYLTA ECNYGGRVTD AWDRRAIVTI LADYVNPDVV
GDVRYKFAVD DRFMVPRKTE HRDILRFVDE NYPSLASPEV YGLHANSGIT RDLNTSKTLL
DSMILIMSSE FTSSTGGGQS PEQALLDTIN QIIVAMPPNM DIDAAKKKYP VDYNESMNTV
ITQEMERFLK LQLEIRSSCR DIENAIDGVI VMTPELEGVI GAIKLNRTPS KWMKKSYPSL
KPLSSYAQDL FKRLNWLHDW HHYGKPPTFW LSGFFFTQAF LTGAMQNFAR KYKIPIDTLT
FDHELLDELT KTKPPLDGVY VNGLFLEGAR WNWEKKLVDE QLPKVLIYPM PAIYLKPVLI
THLAEGSRYK SPLYKTGERK GTLSTTGHST NYVIPVFLNT KVKASHWVKR SVALLCQTSD
//