ID A0A1A9WHG4_9MUSC Unreviewed; 1214 AA.
AC A0A1A9WHG4;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
OS Glossina brevipalpis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI019886-PA, ECO:0000313|Proteomes:UP000091820};
RN [1] {ECO:0000313|Proteomes:UP000091820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GBRI019886-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI019886-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR AlphaFoldDB; A0A1A9WHG4; -.
DR STRING; 37001.A0A1A9WHG4; -.
DR EnsemblMetazoa; GBRI019886-RA; GBRI019886-PA; GBRI019886.
DR VEuPathDB; VectorBase:GBRI019886; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000091820; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0030301; P:cholesterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 194..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 688..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 762..782
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1033..1052
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1059..1079
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1085..1107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1128..1150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1162..1185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 547..712
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1214 AA; 135922 MW; 50257006139F2C13 CRC64;
MFFSVQVNIL NTNIKLAANF LDRCPSCMAN LVRHLCEFTC SPKQSEFMHV VTTEISKNGQ
PYVNNIDLHI TANYTNSTYK SCSQVSVPST GQLAMDIVCG SHMAARCSAT KWFTYMGQAS
DNIYVPFQIN YIQHQNNTPS KNGYRPLDPK TVPCYKPLND KTPACSCTDC EGSCPKPPPE
PPTPQPLTIG GFDAFTVIMV VVFLVGTLLF LMGVCLFPSK NMDADGNEVD GPPHDSIDAM
TTSESGYFEH LGAKTEQYLE NFFTSWGKLF ATYPWFTLLG GLLFVAALGY GIKFLHVTTD
PVKLWASPQS RSRVEREFFD SNFQPFYRIE QIIIKAVDLP DIVHNTSNGP LYFGPVFDKQ
FLTDVYHLQE EIKNLGKGIE NATMLKDICY APLTSGESGS VETANCVVQS IWGYFQDELD
RLDDEDEDNG FEVTYLDELY ACISNPYLCL APYGGPVDPA IALGGFLKPR EQLSGDTNYE
KANALILTFL VQNHHDKEKL GPALEWEQRY VHFMLNYTKT RMSKHMDIAF TSERSIEDEL
NRESQSDVLT ILVSYLIMFA YIAISLGHVQ EARRAFIDSK ITLGVGGVII VLASVVSSVG
VFGYIGVPAT LIIVEVIPFL VLAVGVDNIF ILVQTYQRDV QRADETHEEH IGRILGRVGP
SMLLTSISES CCFFLGGLSD MPAVKAFALY AGMALLFDFL LQITCFVSLL TLDTKRQAEN
RLDVCCFIRG KKTDAVPITE GLLYKFFKSV YVPFLMKKTV RVIVMIVFFG WLCSSIAIAP
RIEIGLNQEL SMPEDSFVLH YFQSLNRYLS IGPPVYFVLK SGLNFSESFD QNMICSGQFC
NDDSLITQIY LASRRSNKTY IARPASSWID DFFDWSQATS CCKYRPETGG FCPHTDTTCN
TCVINRNKLQ RPDEKDFGKY LPFFLQDNPD DSCAKAGHAA YGGALRYHHS SENGVIVDAS
YYMAYHSILK TSADYYLALR SARKISANIT HILQGRLMSQ GMPFEEALKV EVFPYSVFYV
FYEQYLTMWP DTLQSMGISV LAIFIVTFLL MGFDIHSSLV VVITITMIVI NLGGNMYYWN
ISLNAVSLVN LVMAVGISVE FCSHLVHSFS ISTEGTREKR AADCLTKMGS SIFSGITLTK
FGGILVLAFA KSQIFQVFYF RMYLGIVLIG AAHGLIFLPV LLSYIGAPMN KVKLENFRRE
AFKVQETSLS TVRF
//
