ID   A0A1A9WJC8_9MUSC        Unreviewed;       800 AA.
AC   A0A1A9WJC8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=Cullin-5 {ECO:0000256|ARBA:ARBA00040451};
OS   Glossina brevipalpis.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI021916-PA, ECO:0000313|Proteomes:UP000091820};
RN   [1] {ECO:0000313|Proteomes:UP000091820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GBRI021916-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI021916-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   AlphaFoldDB; A0A1A9WJC8; -.
DR   STRING; 37001.A0A1A9WJC8; -.
DR   EnsemblMetazoa; GBRI021916-RA; GBRI021916-PA; GBRI021916.
DR   VEuPathDB; VectorBase:GBRI021916; -.
DR   OrthoDB; 5474206at2759; -.
DR   Proteomes; UP000091820; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF76; CULLIN-5; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          436..646
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          117..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   800 AA;  92068 MW;  1E3BF4F7D63BA6AA CRC64;
     MLKGKAQRSF EDIWPAMRII VLKLLKQETV SQVEWQDLFY GVHLVCLWDE KGAAKIYDCL
     RTDIVEFIVN AQRKVQNQRG EQALLMTYIV EWRKFFTQSN YLPLPFRQLE HSFQSKVPSS
     SSATSSTSTS ASSSSAATAS SSSAAGASTS SSASASLSSS NKKNPTEDSI VRKLMLDSWN
     ENIFKDIKDR LQESAMRIVH AERNGDAYDA QLVIGVRESY VNLCSNPDDK LQIYRENFEA
     AYLDATAAFY RLNAAEQQQV NGVLAFMKYA DAKLREEEAR AKRYLEPSSY GVLAQTCVKV
     LVGDHMNTII AECAPLIKEY ETDRLNLMFR LLDRVPNGTL PMLRDLENHI VSAGLADMLS
     ASEIITQDSE KYVERLLELF KKFSALVKKA FSDDPRFLTA RDKAFKTVVN DTSVFKLELP
     TGIQNRGVKY TAPESKCPEL LANYCDMLLR RTPLSKRLTS EQIDGRLRDV LLVLKYVNNK
     DVFMRYHKVH LTRRLILGTS ADSEKEEDIV EWLREVGMPA DYVNRLARMF QDIKVSEDLN
     TQFRNSTGRH DAINIKILNA GAWARCSERV SVSLPLELED YIPDVEEFYK KKHSGRKLQW
     YHHMSNGTIT FVNNFGRYDL DVTTFQMAVL FAWNQRPHDK ISYENLHPEL RRTLWSLVAF
     PKLKKQILSM EPNCPTPKDF TENTLFQVNQ EFAVVKNGKS QRRGKLNLIG RLQLSTERSI
     QEDNQSIVQL RILRVQEAII KIMKMRKRIN NATLQAELID ILKNMFLPSK KMIKEQLEWL
     IEHKYMRRDD DDINTFIYMA
//