ID A0A1A9WJE8_9MUSC Unreviewed; 4654 AA.
AC A0A1A9WJE8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 08-NOV-2023, entry version 36.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Glossina brevipalpis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI021941-PA, ECO:0000313|Proteomes:UP000091820};
RN [1] {ECO:0000313|Proteomes:UP000091820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GBRI021941-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI021941-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 37001.A0A1A9WJE8; -.
DR EnsemblMetazoa; GBRI021941-RA; GBRI021941-PA; GBRI021941.
DR VEuPathDB; VectorBase:GBRI021941; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000091820; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1995..2142
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2277..2406
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2630..2803
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3256..3290
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3476..3524
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 83..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4654 AA; 534058 MW; DE4D2D42B966D846 CRC64;
MAADAGEAQR RREECERKAR RGEMDPRLEF TFQLLIDATQ LPRHQLMDYI FEGDMLDEIN
QLFLPNMKNK LLWFYQAVDE SETQPIQDPN KPSTSRASTT SKTPQCGGGS PGSSVIAKPK
KLFLTDGWTC ALTGVCIYIF RLNTSKQLPE EGFQKDLYCG IIDAENVGLV TSIERIVEHV
FMQALAYPNT EADEEDISCG LIKGQLLPGL RSFCSALRVC EQVCNTYNVF KDGLDLFEAV
HDLGEVKDMS KNQDFCHQLE ERVANWIKGI MKILGESEQL RRENDSSGPQ DELEYWKKRG
AQFSQLLNYL HEKEVQYTLE CLTFAASRTA IRDWKETDRK ITFCYNEARD NSKFIQAMEN
CCHSLYLDDP VCMKESILSL LQTVRLIYTV SQFYNTSERT SALMVKITNQ MIETCKSYIT
CRCKETIWSQ DRDLVRSKLS NCIKLNHIYR ETYYAVREQP FLPNQTPFGF SENFVFGKFD
TFCERLSKII SMFNLIDDYN HLFDRRLEGL LLGEALEEAN NQFEEAKKDV LSKKYDYLDH
RNAEFNDDYE RFIVKIDTLK ETIANLIETQ FDTVWETPQC IRFLIRFEKV SKKIPLTKMD
EKYTRIIRYV EKEVDRILKV FRKQRDDPPI CRNFPPIAGR IYWSRSLESH MTELMAAVCD
HEVLSKLPPT KDLENRYNHV MDILGEYEDE IVAIWLDQDV SVADACLVQP LLALQGDRLF
VNLHPTITLL IREAKLLAKL KIELPIVAAT LMCREEYFLS IQDSMNCLIS MFLTTVRAVK
LEVRPLFLPQ LVRLTAMLKP GLTSINWTNQ NWRKFYERCK QAIETFKVLV ARIHDIYSNR
ILHVLMCMQE ISLPVLPGDD EIWTVDEFLE KSEEACRKAA IELNRKSQMV SEAVEEVLNL
VDKATETFKE IAGDDVVTLF DASPKEQQTS ARRGMDTTGP STSASAAAAA SSGNPADSGV
GGSGQQQDWS ILWSCFDNPL NLLSTSESLP KGMQDMVCNA VVEMRRYYSR KVIDVLIKVI
RITLDTIRRR FVDDENDGSA RKPIFALYAQ LQIPNVIIKP NLDELQEILI TAGKNITGIA
KGVAQWASGK ENPQVSITPQ PRQGRNHNIK RRKLYTLASE ERPQMPYMLK SFYSAIMDNK
EVAKALNLLS NCAKNIKPEI QTYVKRWKPY HFLWKNDRTT RQLMEFGLQE FESTLRCLAD
LDANLLMEPE IEVFGQCVAV YNERLKYGLA IEIKSCNHKI GQAMKKKYKK EMDYVYAVIN
EMDRKLDRPI RDLDDVRMVM ETLSKIREQE VDMELRIDPI EEAFNVLTRY EVQVEREQFD
LVDNLRATFQ NLLSCALQAQ VKLLDMQPTF QDDLKNNLDR FKQDKIAYVN EYRTAGPMQS
GLTPREASDR LILFQNRFEG MWRRLQTYQS GEELFGLPQT DYPELGQIRK ELNLLQKLYK
LYNDVIDRVS SYYDIPWNEV DIEEINNELM EFQNRCRKLP KGLKEWPAFH ALKKTIDDFN
DMCPLLELMA NKAMKPRHWQ RIMDVTRYTF EFDSEGFSLK NILEAPLLKH KEDIEDICIS
AMKEKDIEAK LKQVTNEWSV HELQFMSFNN RGELLLRGDT TAETIGQLED SLMVLGSLLS
NRYNAPFRKQ IQQWVYDLSN SNEILERWLL VQNMWVYLEA VFVGGDIAKQ LPKEAKRFSK
IDKSWQKIMQ RAHETPGVVA CCVGDDLLKQ LLPHLQEQLE ICQKSLSGYL ERKRMMFPRF
FFVSDPALLE ILGQASDSHT IQNHLLSIFD NTRHVKFHDI EYNKMMAIIS SEGEMIQLDR
AIRAEGSVET WLTQLLVTAQ QSLHSIIRTA YATINDPNFT LLGFLEKVPA QVGLLGIQMI
WTRDAEMALM QARHERKVMS ETNNKFLDML NTLIDQTTRN LTKMERTNFE TLITIHVHQR
DIFDILCRMN IKSANDFEWL KQCRFYFKED LDKTWISVTD VTFTYQNEYL GCTDRLVITP
LTDRCYITLA QALTLSMGGA PCGPAGTGKT ETVKDMGKTL AKYVVVFNCS DQMDYRGLGR
IYKGLAQSGS WGCFDEFNRI ELPVLSVAAQ QVAVVLTAKK EKKKSFIFTD GDTIEMNPEF
GIFITMNPGY AGRKELPENL KIQFRTVAMM VPDRQIIIRV KLASCGFLEN ITLARKFYTL
YKLCEEQLTK QVHYDFGLRN ILSVLRTLGA AKRRNSRDTE STIVMRVLRD MNLSKLIDDD
EPLFMSLVSD LFPNQTLEKT NYTELEAAIA QQTEEANLVY HPPWVLKLIQ LYETQNVRHG
IMTLGPSGAG KTTCIHTLMK ALTQLGDSHR EMRMNPKAIT AAQMFGRLDV ATNDWTDGIF
SALWRKTLKL KSGEHVWLVL DGPVDSIWIE NLNSVLDDNK TLTLANGDRL TMAPTVKIVF
EPHNIDNASP ATVSRNGMVY MSSSGLDSRP IVQAWLKNRA PGEKMVFSDL FKRTFVQVFS
WGTQNLQLLM PVLQCNIVRQ MLCILEGLVP VKNDDEQAVS VSSKDSQEED AIEDAIVEEK
KDTCTPEHLH RLYIFALAWG LGAYLCSADR MKLNLYIKET FPDLDYAKGT AAENSVFDFF
VSPAGTWQSW KTLVTPYMYP EVSTPDFLNI LVPIVDNVRM DYLIGTIANQ EKAVMLIGEQ
GTGKTVIMKN FMKKMNCETY MSRSFNFSSA TSPYQFQRTI ESYVEKRVGV TFGPPGGRKL
IAFIDDINLP EINEWGDQIT NEIVRQSMDM KGFYSLEKPG DFTTIVDVQY VAAMGLPGGG
RNDIPSRLKR QFCVFNCNIP DNESIDKIFR VIGEGHYNAK RGFIPEVRNL VKKLIMVTRL
MWQHTREKLL PTPAKFHYVF SLRDLSRVWQ GMVGTLSTVI TTESVLMALW KHECTRVFAD
RFTNIHDKEW FSSELMCVVG SELGENYVTM IIPNPVFVDF MRDAPEPTGE EGEDADMELP
KVYEPVNSHE TLRERLVMFL AQFNEMVRGS GMDLVFFPDA MLHLVKISRI IRHPRGNVML
VGVGGSGKQS LTKLASFIAG YKTFQIALTR SYNVANFLED LKLLYRTCGV QGKGTTFLFT
DMDIKEEGFL EYLNNILSSG VISNLFSRDE QSEIIQELTP IMKRENQRKS ATPESVMEFF
LTRTSSNLHV AFCFSPVGET FRSRVQRFPA LVSGCTVDWF QPWPKDALVS VSRHFLSDFE
IECTPEIKEE LVNALGSIQD VVAETSQEYF QRFRRATHVT PKSYLNFIAG YKNIYQLKQK
ELGDGVEKMD TGLEKLKEAS ASVEILKKDL VVMEEELVEA SKKAESVLAE VTERAMQAEI
VKNQVLIVKD KAEALVACIA HEKALAEEKL EAAKPALEEA EMALNTIKPA HIATVRKLGR
PPHLIMRIMD SVLILFKRKL HPCIPDSGTP CPKPSWQESL KMMASATFLL QLQNYPKDTI
NDEMIDLLQP YFRMEDYNMD MARRVCGDVA GLLSWTKAMS FFHSVNKEVL PLKTNLTMQE
ARLKLAMDDL AAAEDQLHER EEALQAVKNQ YDKAVGEKQR LTDAANVCLR KMTAATALIN
GLSDEKIRWT NQSKEFKIQL GKLVGDVLLA TGFLSYCGPY NQDFRANLIR TWMSILRQKA
IPFTISLNII NMLVDSSTVS EWTLQGLPND ELSVQNALIA TKSSSYPLLI DPQTQGKLWI
KSKEDQNELQ ITSLNHKYFR THLEDALSLG RPLLIEDVGV ELDPVIDNVL EKNFIKSGSI
EKVLVGDKEC DVMPGFMLYI TTKLPNPPFS PEISAKTSII DFTVTMRGLE DQLLGRVILM
EKSDLEAERV ALFETVMRNQ RNMKELEANL LYRLSSSQGS LVDDEALIEV LRVTKTTAEE
VNQKLKISEV TERKIMKARE EFRAVAARGS ILYFLIVEMS NVNVMYQNSL KQFLVIFNNS
ITKSTKSSIT EERINIILRY LTYEVYKFTN RSLYERHKQL FTLMLAIKID YHKGNISHEE
FMAFIKGGAS LDLNAVTPKP FRWILDITWL NLVEISKLET FANVLELIEA SERDWRIWYE
SEKPENEEIP CGYQSSLDGF RKLLLIRSWC PDRTVSQAKR YIEESLGSEY SEMQILDLEL
TWSESESRTP FVCLLSIGSD PTTQIAALAK QKGIPLKSVS MGQGQECHAR KMIMDAMSSG
GWVLLQNVHL SLPFCSEIID MLVETEYVDE TFRMWVTTEP HNEFPIGLLQ MAIKFTNEPP
QGIRASLKRS YQAFTQDFLD YTSASQWPTL LYTVAFLHTI VQERRKFGPL GWNIPYEFNA
ADFAASVQFI QNHLDEMDPK KGVSWQTLVY MIGEVQYGGR VTDDFDKRLL NTFTAVWFCE
GLLSPSFEFY KGYKVPNTKS LQGFIDYINM LPTYDTPEVF GLHSNADITY QINSAKGILD
TILSVQPKEG GGGGGETRES IVYQLADDML RKLPQQYNTY EVRENLTRMG ILLPMNIFLR
QEIDRMQRVL KRVSSCLCDL KLAIDGTIVM SPALKESLDA MYDARIPDIW MKISWESTTL
GFWYTELLER NTQFRTWLST DRPKVFWMTG FFNPQGFLTA MRQEVTRAHK GWALDSVVLQ
NQITRYNKED ITEYPTEGVY VHGLFLEVLY EQMPVIYIFA INTTAGKDPK LYECPIYRKP
QRTDSKYVGS IDFETDLNPK HWTLRGVALL CDIK
//