ID   A0A1A9WL64_9MUSC        Unreviewed;      1121 AA.
AC   A0A1A9WL64;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
OS   Glossina brevipalpis.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI023600-PA, ECO:0000313|Proteomes:UP000091820};
RN   [1] {ECO:0000313|Proteomes:UP000091820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GBRI023600-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI023600-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A1A9WL64; -.
DR   STRING; 37001.A0A1A9WL64; -.
DR   EnsemblMetazoa; GBRI023600-RA; GBRI023600-PA; GBRI023600.
DR   VEuPathDB; VectorBase:GBRI023600; -.
DR   OrthoDB; 1003028at2759; -.
DR   Proteomes; UP000091820; Unassembled WGS sequence.
DR   GO; GO:0034703; C:cation channel complex; IEA:UniProt.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR024862; TRPV.
DR   PANTHER; PTHR10582:SF2; INACTIVE; 1.
DR   PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        494..514
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        534..555
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        562..584
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        630..657
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REPEAT          172..204
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          230..262
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          506..661
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          419..439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1019..1040
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1121 AA;  126590 MW;  14C87C8EF5760FEF CRC64;
     MKFFLKRCLR KKPQEMRPGA ILDAVISQSS ATTNKCLLYK LADFKRGGDL IDAINTGGLI
     AVEQLIRDQF AVFMYNDGKG QVINRAEFLR WKYRDHTEVT IPIEASLSMH DPLGKWQDHS
     ACWQMQYRGA LGESLLHVLI ICDSKVHKKL ARILLRVFPR LALDVMEGEE YLGASALHLA
     IAYSNNELVA DLIEAGADIN QRAVGSFFLP RDQQRSNPAK STDYEGLAYM GEYPLAWAAC
     CANESVYNLL IDHGAHPDAQ DSFGNMILHM VVVCDKLDMF GYALRHPKTP AKNGIVNHGG
     LTPLTLACKL GRAEVFREML ELSAREFWRY SNITCSGYPL NALDTLLPDG RTNWNSALFI
     ILNGTKEEHL DMLDGGIIQR LLEEKWKTFA QNQFLKRLLI LMVHLLCLSV SVYLRPMHDT
     DDDEDNDEDS EYNSNGREDK KLNKEVEEYD VQTIARYCAE LATIAGVLSF LIFQQGDEIK
     NQGLSAFLKQ LSHAPAKAIF LVSNVLILSC IPFRLMGDTD TEEAILIFAV PGSWFLLMFF
     AGAIRLTGPF VTMIYSMITG DMFTFGIIYS IVLCGFSQAF YFLYKGHPQL QSTMFNSFAS
     TWMALFQTTL GDYNYPDLNQ TTYPNLSKTV FVMFMIFVPI LLLNMLIAMM GNTYAHVIEQ
     SEKEWMKQWA KIVVTLERAV PQGDAKNYLE AYSIPLGPSD DSGFEVRGVM VIKSKSKTRA
     KQRKGAVCNW KRVGRVTLNA LKKRGMTGEQ MRRLMWGRAS ISSPVKITKK KLKDPYNLHP
     ELAIQANITS AMDMLNFAAK PSTDVSLCSK TATAPTDNII PPTDPIRDLI IMAEEKPETH
     DPQFYADLIQ LANKAFELVE LVKSQPIEVK RTITTTDATS EIDLNIIKSN EIFMQEDDMI
     KEISNGEDLP LPGNLTSLFQ DPKDIVDPQK LEQFLKMVAE VETEESDGGG PILGKLSLAR
     RTRMALFKAT IPENNLENGA ENLITSVWDH VSQENVDDIP NFDFQEALAI EHVLTVEQEA
     EVETEDGNDQ TGATSDDKST AEEIHATMKH FHLRKRQYQQ DDAARRAKSA RVTRKNSTKA
     KELWCFILKR KIRAYEVKRE LCNQKAGMSC LRFVLFSNCH R
//