ID   A0A1A9WQC8_9MUSC        Unreviewed;      1624 AA.
AC   A0A1A9WQC8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=W2 domain-containing protein {ECO:0000259|PROSITE:PS51363};
OS   Glossina brevipalpis.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI028089-PA, ECO:0000313|Proteomes:UP000091820};
RN   [1] {ECO:0000313|Proteomes:UP000091820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GBRI028089-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI028089-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC       {ECO:0000256|ARBA:ARBA00005775}.
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DR   STRING; 37001.A0A1A9WQC8; -.
DR   EnsemblMetazoa; GBRI028089-RA; GBRI028089-PA; GBRI028089.
DR   VEuPathDB; VectorBase:GBRI028089; -.
DR   OrthoDB; 92033at2759; -.
DR   Proteomes; UP000091820; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd11559; W2_eIF4G1_like; 1.
DR   Gene3D; 1.25.40.180; -; 3.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR049485; eIF4G1-like_eIF4E-bd.
DR   InterPro; IPR045208; IF4G.
DR   InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   InterPro; IPR003307; W2_domain.
DR   PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR   PANTHER; PTHR23253:SF9; EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED; 1.
DR   Pfam; PF21140; eIF4G1-like_eIF4E-bd; 1.
DR   Pfam; PF02847; MA3; 1.
DR   Pfam; PF02854; MIF4G; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SMART; SM00544; MA3; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; ARM repeat; 3.
DR   PROSITE; PS51363; W2; 1.
PE   3: Inferred from homology;
FT   DOMAIN          1462..1624
FT                   /note="W2"
FT                   /evidence="ECO:0000259|PROSITE:PS51363"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          943..1049
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1095..1216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        947..986
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        997..1039
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1108..1123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1125..1176
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1624 AA;  182503 MW;  5824D024C83CA67D CRC64;
     MQPQSAQNMF VPQNAAGNNN GNVRSNPQSN NNMFRQTPSS PAPRSRFMPS TMFPSTVQSV
     VLQQYPYVNP TRQPQYQQFS YAHQYYQQNS FYSFYPLQQP PQHQRAATIS VNSGVGVGVG
     SGISGAVAGP TTANQAQISL SVPPVGNAVL GVTNSTPAQP VGVNTMVGVM QSPQPTTRKI
     RRHALEIIDP NTNRNILEDL KSEKGASSAD VESQDSVAAA QLIPTKVPEE VGQIMRTTSE
     FRNYDIDARE ASEEEEHNTI NQTPVVSVMS APEIYPAQMQ KTKSKKLQIT KTDQNVRNMA
     KLDEDTRKPP RNNESKSVTN SECIHEEIVQ NYPINKSPQV NVGTQHLEDF GVRDTSSSEN
     SLILNNMPRE ADHQLEQQSG LTCLNDESVV KQTCAEEVIV DPRSKQIDEK EMLAATAQDA
     VSSNEQTAEE QTTSIAEFND NFTPPLDTNY GSTEENKNNI FEDSLKSVNP HTGCDDTTRV
     IAIKIGVCEV DLNETNPAFD AELDNNENIK GLREKSNTED THLNYAKSNI EVKSEENSTN
     FNNDISSTTK TFSIVSPNNH SPTSKRKYNR EQLMDLRDAK DSRVQPDIKI TSILPGFNLM
     PAFALNNANK KFQPLVGSIG GNSSFSKNYT KQVSNSSIGA AHVTDDSKPM IHVNLSLNQD
     VQLNEIANAW RPRVLLKGNE IDNDPKAKAH REKEELVRRV RGILNKLTPE KFDPLVKEIM
     ELKIDTMDKM EAVMILVFEK AIDEPNFSVC YARLCARLIS EVKAKDEKTE SGTKTHLVQF
     RNALLDKTER EFTCNVIDAK AKEQKLKPIR DKIQNCKNVH EKVELEALLE EEERKIRRRS
     GGTVRFIGEL FKISILAGKI VVTCIESLIK FPDNEDMLEC LCKLLTTVGQ KLELFRDQNR
     FYMLDGVIHR MQVIASKSEN SKISSRVRFM LQDVIDLRKN KWKSAARTRN ETPTTLDQIE
     NEAKNEEYYN YSVSLSSTGG SSGNGGKRDD RSSRYGGDNR LNYNGSHSQR GDTNSLKRNQ
     QIGAGSHSAS GNDGTWHIQT GKGSRPLAVD PNKLEALHNF DITNKKMGGV QQFQWSKSTT
     IVTPSNSFAA LSVLDSNKSG GRNKSAHTHN KGSIERDRYG DRGLLSRSGS SQASRENSSS
     RSSQSVRNMT TTASIQKSAS HSKYIQSSST PKITEKPTSF AVIPPGSGSS SISRDKRDDD
     QPSTQFQQQQ QDHQHHNIAC ETGLSAAPDA VFEEPSDADL KLIKSVVSEM VEIAANSKQI
     DFSTVACIER IKESQLCSLL YYIITDYLHL RDVGSFHRRL LSNCIAYLIE KNVLSIDHFN
     LAYEQFASLA SEIIVDVPDM YLYILEFAGK YYSGNKFIYK INSISWCTGP LIVRKILTIH
     DLWTKKLRKA ESTNSEMGKK FLKTYLQYCT REIGPSFTRN MFRKFNMKWS DYMPESEVDK
     FIQTNKFEFV ENDKHHPEID IRETKEKRYA RMFDHIEQIL KEDANADNVI DYINGNIADV
     DKAFIRGLTT TLASFAIKDS SNYKLDGACF QKKCIPVLIR YIDSKEDREL ECLYALQLLV
     HRLEHPRHLI SDLFIKLNEY DVIPQDTFIR WRESTAQTVG KGVAVKALNP FFNQILNGET
     SDDN
//