ID A0A1A9WX43_9MUSC Unreviewed; 424 AA.
AC A0A1A9WX43;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
OS Glossina brevipalpis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI035574-PA, ECO:0000313|Proteomes:UP000091820};
RN [1] {ECO:0000313|Proteomes:UP000091820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GBRI035574-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI035574-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate
CC from fumarate: step 1/1. {ECO:0000256|ARBA:ARBA00004859}.
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
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DR AlphaFoldDB; A0A1A9WX43; -.
DR STRING; 37001.A0A1A9WX43; -.
DR EnsemblMetazoa; GBRI035574-RA; GBRI035574-PA; GBRI035574.
DR VEuPathDB; VectorBase:GBRI035574; -.
DR OrthoDB; 1341425at2759; -.
DR UniPathway; UPA00223; UER01007.
DR Proteomes; UP000091820; Unassembled WGS sequence.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
PE 3: Inferred from homology;
FT DOMAIN 1..298
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 373..421
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
SQ SEQUENCE 424 AA; 46434 MW; D26CC6B3C7260D2C CRC64;
MGILKKGAAE VNKDFCLDNE LSDAISKAAD EVISGELYDA DHFPLAIRQT GSGTQTNMNC
NEVISNRAIQ LMGGEMGSKE PIHPNDHINM GQSSNDTFPA TVHTSVAMEL DNNLIPALTE
LNDGLKRKEN EFSNIIKISR THLIDAVPLT LGQEFSGYSQ HIRNGLARIN ACLPRVYELD
LRSTAVGIGL IYRKGYAEKC SARISEITCL PFKTGLNFYF EALGARDAMV QVHSILNTIA
MGLMKMANDV HFLGSVNYRL DLGELSLPEN APGRSAMPGI VNPKQCEFLT KICAQVMGNQ
LAVTVGGSNR HFGLNVFKPV IVSNVLRSIR LLCKIALFSN AATGCRTFNK NYLKGIKANK
ANIEKIMNES LMLVTALNRH IAYDKAAKTA NKNCTILEEE ALKVGVTEDD FNKWADPKLM
LGPN
//
