ID A0A1A9WX64_9MUSC Unreviewed; 594 AA.
AC A0A1A9WX64;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=peptide chain release factor N(5)-glutamine methyltransferase {ECO:0000256|ARBA:ARBA00012771};
DE EC=2.1.1.297 {ECO:0000256|ARBA:ARBA00012771};
OS Glossina brevipalpis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI035670-PA, ECO:0000313|Proteomes:UP000091820};
RN [1] {ECO:0000313|Proteomes:UP000091820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GBRI035670-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI035670-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-
CC methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release
CC factor] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42896, Rhea:RHEA-
CC COMP:10271, Rhea:RHEA-COMP:10272, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30011, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:61891; EC=2.1.1.297;
CC Evidence={ECO:0000256|ARBA:ARBA00000932};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A1A9WX64; -.
DR STRING; 37001.A0A1A9WX64; -.
DR EnsemblMetazoa; GBRI035670-RA; GBRI035670-PA; GBRI035670.
DR VEuPathDB; VectorBase:GBRI035670; -.
DR OrthoDB; 1121774at2759; -.
DR Proteomes; UP000091820; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 2.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004556; HemK-like.
DR InterPro; IPR040758; PrmC_N.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR NCBIfam; TIGR00536; hemK_fam; 2.
DR PANTHER; PTHR18895; HEMK METHYLTRANSFERASE; 1.
DR PANTHER; PTHR18895:SF74; MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE; 1.
DR Pfam; PF05175; MTS; 2.
DR Pfam; PF17827; PrmC_N; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR PROSITE; PS00092; N6_MTASE; 2.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 31..100
FT /note="Release factor glutamine methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF17827"
FT DOMAIN 141..225
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
FT DOMAIN 309..378
FT /note="Release factor glutamine methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF17827"
FT DOMAIN 418..503
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
SQ SEQUENCE 594 AA; 68022 MW; 7EF31162B24A1C11 CRC64;
MNYIKPFWMR FITRFTKVPK KAETRDVISH LLADWNQKLK QAGVGDRETN IKYLMERVIR
KPLPSYESIK RLELTEKQLR EFEELSKMRC DRRPLQHIVG VWNFNGLRLK MNPAVFIPRP
ETEEFVSEVI QHYRNISKPI EMLEVGCGSG AISLAMLQSI PFIRSCTAID CCDAAVKLAK
ENANELRLGG RFQSFQHMVK ENDYLPRPLK GKTYDLIISN PPYARTDELV WLNPEVKRYE
NRIALDGGVD GLDVVRLVMD LACFHLRSGA KLWLELGNGQ SPLVKTIIYL FHALNDSHNH
VQSVEVKTAI EGWKEKLKES GVGDIEFNLK CLVAHVLNRK FSTLKSYDAE KFTAQQHSEF
SRLCEARCAR MPLQHILGEW DFMDLTLKTA PTVFIPRPET EEFVLKIIEQ CQNVQKPIDM
LEVGCGSGAI SLAILNALPH VSSTGIERSK AATALAWENA KLLKLSDRFT PYNHTSAANN
YLPKELLDRK FDLIVSNPPY VRTEEFPLLQ PEVKLYENLN ALDGGSDGLN VARLVFDLAC
LHLHPGGKLW LELGSEHPPL VKTIMNLKYE GRLRFISSYN DQYKRDRFVE IEKV
//
