ID A0A1A9X044_9MUSC Unreviewed; 846 AA.
AC A0A1A9X044;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 03-MAY-2023, entry version 26.
DE RecName: Full=Malic enzyme {ECO:0000256|RuleBase:RU003426};
OS Glossina brevipalpis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI039315-PA, ECO:0000313|Proteomes:UP000091820};
RN [1] {ECO:0000313|Proteomes:UP000091820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GBRI039315-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI039315-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the malic enzymes family.
CC {ECO:0000256|ARBA:ARBA00008785, ECO:0000256|RuleBase:RU003426}.
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DR AlphaFoldDB; A0A1A9X044; -.
DR STRING; 37001.A0A1A9X044; -.
DR EnsemblMetazoa; GBRI039315-RA; GBRI039315-PA; GBRI039315.
DR VEuPathDB; VectorBase:GBRI039315; -.
DR OrthoDB; 3488372at2759; -.
DR Proteomes; UP000091820; Unassembled WGS sequence.
DR GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd05312; NAD_bind_1_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR015884; Malic_enzyme_CS.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23406:SF80; GH17657P-RELATED; 1.
DR PANTHER; PTHR23406; MALIC ENZYME-RELATED; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR PRINTS; PR00072; MALOXRDTASE.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00331; MALIC_ENZYMES; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003426};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003426}.
FT DOMAIN 361..542
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 552..806
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
SQ SEQUENCE 846 AA; 95106 MW; 8AB0BEEA1057A907 CRC64;
MGIQYFQLLE MYYQNLRQLL VVHRCLRIGI NPSDINPLAE IISNRQLPYQ RKRQQLYYRL
LPKYNQHYRQ PIENVGKLQL ISGDKAFIRT SKAVGNQGIN ISVNSTNKFS YSLAIKRACE
LFSSCYENTG TAAITALRLL PKKIHTTTAR VERELWTNKK CWRVSTSGTS NVSKKVWTLY
SDKYTTQSNN IMKQQYLKTK SETIKKQKSY GKANTKSFKL SILAQNIRKA FSETLDTVPL
FKQTHGLFKG SALKYQQRFN YTKDCDGDQS DDRQLAPRDR MGFWGTGGGD IPGKICGIGR
LRNKKYNKGL GFNFTERQLL GIHGLLPCVY EDDKKQIARC VALLDTFEKP LHKFMYLYTL
SENNERLFFK VFASNIPKIL PLVYTPVVGL ACQNYSMIYS HHKGLFISIK DKGHVYDVLK
NYPENAIRAI VVTDGERILG LGDLGANGMG IPIGKLALYV GLAGFKPEHC LPITLDVGTN
NDTLLKDPLY IGLRQKRPKC EIFEEFIEEF MQAVVRRFGQ NCLIQFEDFG NFNAFGLLAK
YRDHYCTFND DIQGTASVGA AGLLASTRIK GDKLSGKKFL FFGAGEACLG LANLLIKVMV
EEGVSEADAK KLIWMFDSKG LIVKNRPKGG LTEYKEVFAQ DHAPVDKLLD AVKTIKPAVL
IGGSTIGGAF TPEILGLMAE YNETPIIFAL SNPTHKAECT AEQAYTATKG KCLFASGSPF
NPVKYNGKTY HTGQCNNSYC FPGIALGVVC SGMLTVPEDI FYITAQKLAD LCDVEQDLKV
GRLYPPLEKI TTISLEIATH VMQYAFDNCL ATLHPEPENK KEYIKNQMYK LDYPSAVPKT
FDIKTK
//