ID A0A1A9X1J8_9MUSC Unreviewed; 1770 AA.
AC A0A1A9X1J8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=PWWP domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Glossina brevipalpis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI040784-PA, ECO:0000313|Proteomes:UP000091820};
RN [1] {ECO:0000313|Proteomes:UP000091820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GBRI040784-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI040784-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 37001.A0A1A9X1J8; -.
DR EnsemblMetazoa; GBRI040784-RA; GBRI040784-PA; GBRI040784.
DR VEuPathDB; VectorBase:GBRI040784; -.
DR OrthoDB; 764287at2759; -.
DR Proteomes; UP000091820; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15538; PHD_PRKCBP1; 1.
DR CDD; cd20160; PWWP_PRKCBP1; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR044075; PRKCBP1_PHD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46453; PROTEIN KINASE C-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR46453:SF5; PROTEIN KINASE C-BINDING PROTEIN 1 ISOFORM X1; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50812; PWWP; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT TRANSMEM 1456..1477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 390..436
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 582..633
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 36..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1523..1573
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 272..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..878
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..925
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1770 AA; 196338 MW; C9A84A44F6A18D4D CRC64;
MESTRKIFRP MKNTLHLEVE ENLDGGVQEK EKELIGQEYE NNSEEEECSE FDEITMPDTN
GKTTDTEQEF LPYTPDSAKE VMHIKSSKLT DCLAGRRSSE SIAKFSSHST SKLASTCRII
APTSREHMAL QRSINESKIL TDYLKTSKIH SRKLRDKDAS NKCSDMSSTD DRDVVSIGIK
SKRSKRRFVP LKGGTTENNA VTSNSDLIAR PSCSKRYTKS LDYMERDKIA KWPSEEPPVP
KRTNMRSENP DFLQKNKDFL KRVKHSSETP ERCLSRSSTG SRVITRSRSS SKSAGRYDNE
LSQYHQANDK YGLEIENCDK IAPNSMEIEI ADSSLGVGVC SGQPYSASDI SVNDSNKSLL
NLDGKLNSDE SSLEAHLRNV WQPPLKPGWD SFCWKCHRSH VNYICTKCIR SFHNTCIKIN
APAIGNLWIC PECVAVDNAL NVNPKRFRRN ECSADSLSQL LSIVLNRMRY GKGHHILQIS
DDGDFAIYNK YIVNPVSFSM IQEKIDKRIY RCAEELLNDT KWFLHNASIL SLGRTTKTKM
VAAAKSLIKI CRQETAEIDT CAQCYLNANS RSDWFLDVCD QPHLLVWAKL KGFPYWPAKA
MGIGQGSLVN VRFFGDHDRA FVPLKDCFLY SQQDPNSQTG RRSARELAEC IKEVEMHIER
IKKKVGAFQF APFKAPYDPN EEMQQLERMM PGVHEYIRSQ QSLTTNPPLK LTIGKNAGNT
LSVLQNTSTQ ENSTVQNLES VEASGKKKHL EERDDDGPIK KHENRTKGHT PKYEVISKST
SDDSNSSKLN TVILKRKTAQ GTVNSNDVKR FSATDGGELP PPKISRTEDI SEQLNFVGKH
QLASGINKGN TRDEEISESL LKSKTSKQEA QNGSGTGRKA FLQIPEDALV TSSGDKPEPA
REKNLINRDP QILDKNMENS ESQKERGSQK TNNILKCPVP FVEIKQEETF DNNTESGECV
ILKTASSRTE VRNEDMNLFN NNSDITMQQE FIANTATISN TISTELRTSS PLLTRIKQEV
ISDEEAVNLS PEHHMISIGS VQSVQRISPK SVNTNVTSVS TITSSNIENH NVNTNFTVSG
QNPKTSAAYL TNSKRNSFRG VPYGPLPASA VPQIQSAQIK SAPTEVNQPQ QQHQYHHHHH
QQNQQHQQQQ HQQQRAKKSF PQRSPNRENL RSTSIVSTTS SSIPTSASLV PLTTATAIYS
SLNITSSHQG TDPKQVLNKN TMVTIPVDVA TNRPEVTMDN INTTIPVPPL TAVSKIFSSA
SGLYSMSRTQ QYPGPIIVSS TSTSAITAIS TTTTPVIITT TVPATITHNL AKTLTPSSAL
TPVNLLISNV ETISSESDMN PANNTSQQAI NPLSMSAPPP LAGLSGTNLI CTQICTSANL
SNTNSIAKAT TNTDTHLMGS FVAPIMSSSS VSNEATSRGP PPLLMARPIG PLQAEANIME
AVFVVVLCDV CNGGTGWIVV VGVVLITTAV VSIAYWIGLP FWWQKNQALT ICLLVIKDFF
ISIIEDTLAE LCQGDEVSLQ AKITLLSLEL ERTKNQMSED KRNYELLLNE TRKNLENEKV
RTLNEVRKQY ELERLHAVEE TKRKQWCAHC GRPQQERHQV IKTSSSTSPA IIFNNKNLIT
LKKDKSVRTK SVPQITGISV SNPVHGTEVL KFPPNTYIRH VTSVTSASVV NCNNNNQQPI
RCNAPYSIPA HFFNVSVPTV PSNGSQKYTI VQPSKNWTIS NGANSTLTNA TTISASSTVT
NVTQARTGPN ITTAHKIQVR PRNITEIKPS
//
