ID A0A1A9X3S8_9MUSC Unreviewed; 911 AA.
AC A0A1A9X3S8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|ARBA:ARBA00019081, ECO:0000256|RuleBase:RU365058};
OS Glossina brevipalpis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37001 {ECO:0000313|EnsemblMetazoa:GBRI043213-PA, ECO:0000313|Proteomes:UP000091820};
RN [1] {ECO:0000313|Proteomes:UP000091820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000091820};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GBRI043213-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GBRI043213-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBUNIT: ORC is composed of six subunits.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- SIMILARITY: Belongs to the ORC1 family. {ECO:0000256|ARBA:ARBA00008398,
CC ECO:0000256|RuleBase:RU365058}.
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DR AlphaFoldDB; A0A1A9X3S8; -.
DR STRING; 37001.A0A1A9X3S8; -.
DR EnsemblMetazoa; GBRI043213-RA; GBRI043213-PA; GBRI043213.
DR VEuPathDB; VectorBase:GBRI043213; -.
DR OrthoDB; 118994at2759; -.
DR Proteomes; UP000091820; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd08768; Cdc6_C; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041083; AAA_lid_10.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17872; AAA_lid_10; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00439; BAH; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51038; BAH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU365058};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU365058};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365058};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleus {ECO:0000256|RuleBase:RU365058}.
FT DOMAIN 46..186
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 196..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 911 AA; 103488 MW; 7B2BEBC8C406D5FB CRC64;
MVLKSHQSDM TELIKWIGSP NESGPSSPNF LQRDAFFYNK CAIGPMILNV GDFVLVSNAD
ASEPDTVEGC DIAKILHLYE LQEKSNRDPY RAIVQWYSRP QSIPAKYVNK DELCFDFERE
LIEEHRSYDS DISLETIFRK CSVLYGTVDT SASGLLGHSN RKNNSCPTFI CRYKFIRIKE
KYQLLPLEFE NAESNSVRRS RRKHVDPKNE SAKKARRSTV ISENARMHRD SPSVINPTEL
IDLNYYNDQK VSPIKIVERR RIVSSTANDR FSTPTSRKTA TIKGSPLSEQ NIKVTPTIKA
LKARRNLNSS LEHVVNDTND SDCLNYSIIK NTPDAQKPTN EMKIKLRVSE RHRLVSTEKD
PLALENNTKE FIDFIEAHTN DLYETPTKKL KESATETPNN KRKSILKSAT TRIGTPKRSI
HMSNVVEELV FDKREILSTP TLKSKKSLIF NKEEEDIEKI LQRVTPKKPA EKTPKRGRRS
NSNYLKDSET PKTPKTPKTP SQKLKMLRSG ELTPSFKERE KIDQSKSTKN ILQLARECLH
VSAVPLSLPC REKEFENIYT FLEDKIKDQC GGCMYISGVP GTGKTATVTG VIRALQKQVQ
EEALPTFDYL EINGMRLTEP RQAYVHIYRQ LTGKTVTWEH AHTLLEKRFT TTSPRRMTTV
LLVDELDILC NRRQDVVYNL LDWPTKTTAR LVVITIANTM DLPERLLMSK VTSRLGLTRL
TFQPYSHKQL QEIVTTRLSG SEAFKSEAIQ LVARKVAAVS GDARRALDIC RRATEIADSS
KDKEICVNLL HVQQALSEMI ASAKVQAIKN CSRLEQILLQ AIAAEVARTG IEETFFMGVY
AQLENIAHYS GGVLIPTIGQ VLRLCSKLGA QRLIICEHSR NDIFQKILLN VSMDDIHYAL
KVTSDATTIF L
//
