ID   A0A1A9Z494_GLOPL        Unreviewed;       896 AA.
AC   A0A1A9Z494;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Fork-head domain-containing protein {ECO:0000259|PROSITE:PS50039};
OS   Glossina pallidipes (Tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=7398 {ECO:0000313|EnsemblMetazoa:GPAI003358-PA, ECO:0000313|Proteomes:UP000092445};
RN   [1] {ECO:0000313|Proteomes:UP000092445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GPAI003358-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPAI003358-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR   AlphaFoldDB; A0A1A9Z494; -.
DR   STRING; 7398.A0A1A9Z494; -.
DR   EnsemblMetazoa; GPAI003358-RA; GPAI003358-PA; GPAI003358.
DR   VEuPathDB; VectorBase:GPAI003358; -.
DR   Proteomes; UP000092445; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd20030; FH_FOXN1-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR049624; FOXN1_4.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR46721:SF2; FORKHEAD BOX N1; 1.
DR   PANTHER; PTHR46721; FORKHEAD BOX PROTEIN N1; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          489..586
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        489..586
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          187..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          608..637
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          806..865
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        620..637
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   896 AA;  98112 MW;  1DF9EC3C519FBEC1 CRC64;
     MYLTIDQLCD EFDGAIISEN SVIEWASRSR VFNPCEPPKV GLPGFSLPKK VPYCMDSSGP
     TLDFYISDSL QDMLDVDIRT EIANVVNSRT EYDGCSDGLS SSFDHVTDSC YSSNHLKESS
     SLSESSAHMP SSSTAATFGF TTSTNSSAFW FGSSSDFYAD VGACVNPISV MPLISSSLPH
     MTTKIGTNAN GLHQNTPPPS SPSTNDVKSH LTFSPAQMKI KVNSLRNEQL TSHIPKQIVA
     ISSTVTSATT APATLATNTV LQRKNTNSVE AVKKDLSGEM RKLPDTGIYK AVPCSSTSHV
     STNNVSNDSA STSTIKLGPG IGSLSFANNL TFNKIKQDST QKASQSTAAV TANGSIVLKR
     ERDSSSPLHH ATLNSPTSVS QHVAKLLSRQ GIQSSAGFTP KSIASNAHTA FMQQHLSVSS
     ATSSAGDGSK TTNFTTTISG GIGTFSNGLT TPNTSSTALS SCSNIANGMT VKSLQQKIKA
     APIESEYPKP AYSYSCLIAM ALKNSRRGSL PVSEIYSFMC EHFPYFKTAP SGWKNSVRHN
     LSLNKCFEKI EKPLTNGYQR KGCLWAMNPE RITKMDEEVQ KWSRKDPMAI RNAMVCPDNL
     EALERGEMKH GSTGDSDGEL DSQSEIEETS DLEEQELDET LVDNMLIEDE MEDEEGVNSN
     SLISSNIVMM STSDLIQQDN FNNENRSDAT KSTATSYTSE PETIIMTNTT TMSGKISNQT
     MTTNTSVTHN FDNEVEDIYD TIDIEDDKDD ARLTLNQSDI IELNPADYNT NVSHDENHQS
     PKRARVSYTI AAVSDKQSQS SQQQTQQQQQ QQQQQQQQQH QQQQQQTIQL QNVKKIIKVQ
     NAHDLQHLQQ QLQQQQIIVQ KTLTNGLLAP TQQQQQQLSA TISTNRRKMH LVNRII
//