ID A0A1A9ZD16_GLOPL Unreviewed; 2918 AA.
AC A0A1A9ZD16;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Multiple epidermal growth factor-like domains protein 8 {ECO:0008006|Google:ProtNLM};
OS Glossina pallidipes (Tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=7398 {ECO:0000313|EnsemblMetazoa:GPAI010966-PA, ECO:0000313|Proteomes:UP000092445};
RN [1] {ECO:0000313|Proteomes:UP000092445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GPAI010966-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPAI010966-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 7398.A0A1A9ZD16; -.
DR EnsemblMetazoa; GPAI010966-RA; GPAI010966-PA; GPAI010966.
DR VEuPathDB; VectorBase:GPAI010966; -.
DR Proteomes; UP000092445; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00055; EGF_Lam; 4.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 4.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46093; ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR46093:SF17; MULTIPLE EGF-LIKE-DOMAINS 8; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF13418; Kelch_4; 2.
DR Pfam; PF13854; Kelch_5; 1.
DR Pfam; PF00053; Laminin_EGF; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 12.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00180; EGF_Lam; 4.
DR SMART; SM00423; PSI; 9.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01248; EGF_LAM_1; 3.
DR PROSITE; PS50027; EGF_LAM_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2918
FT /note="Multiple epidermal growth factor-like domains
FT protein 8"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008402787"
FT TRANSMEM 2744..2766
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..157
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 155..186
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1232..1273
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1308..1354
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1355..1405
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1407..1536
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1534..1567
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 159..169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 176..185
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1326..1335
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1338..1352
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1377..1386
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1389..1403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1557..1566
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2918 AA; 327167 MW; D37BA6FF86756854 CRC64;
MRSIVIFGAL LALLHIVGEL PLVLADRVSL LPNTQQMHYH SSSPCDRSRK VFTAEYGEIS
DGPAGFNYTQ DSHCEWLIKA RNNSQFITLS FHSMGTECSY DYIYVYDGDS FNSTLLGSFS
GRTQPQRLVA RSGSMLIFMY SDTNYVLDGF RASYYISNCL NNCHNHGKCV GHQCVCHGEW
VGPDCEDEAC PNKCGELQGQ GKCIKGLCHC EKGYSGRLCD LHEQPPGGNW RWLATDAEGM
TPRAAHTAIY IDEEDALYVF GGYDLNNVIS TLQIYRFAAS QWEDEWGIAL QNRRHYYHQQ
KIDHSLLKAV LQHKNEDEAK LWGLKSDISI FRNILYTLAE SNLHQRQTRS SQLLTAVSIN
STDEELSEYL EDILGEVTDY KPHGRYGHAA ARVPGGFVIF GGKQANGSFF NDLWFYNNSE
SGGKWKQLAM RSKSKPPPMA RHTITFANDY LYLFGGSLET GEFSSNIYRI SWPVFYVEIG
EDEAEWELIH PRGGKKLDVR LAAHTTVYYK ATNSLIVFGG IMTSLARFSK LSDRIFAFQL
DKLHWTEILY PRTALRDTNI PRERAFHTAT ISGNYMIVFG GYTHRHNKDE ICYDNQMYWY
HLSCHIWINQ VVSAEDSLYP KKQGVFAQAA ALRRNNTLLI VGGYHGNINA DLFAYELPQV
LRMQSSNGYN PEMSCRLHTS HTACLSNPEC GWCSADSSCY GRTIGANCTS NLQTTRCPGI
CPSLGDCHSC LVHGTQWNKP QEGSEVYFSV ASKLGLNECT WCVQNAKCHH RDDNYGICGE
DTPSHSPGWW GEQGTEIRQP SQCTQNDRRP GLTYVKYHYP INLTMPDYVA IVNATMVDFA
SPTPTTQYEQ KLEGEMLARL LGFVRPQKQW EEEPTEIQVC TSYSSAILKA GLGKDLISLK
ELVKQTSNQS YCSNVEIPST ELPFLIDFQA RRRIGLNAIY NTYQKTKMEL QHIYHGNLNA
FTFEYLEPYY SGENCAGYRN CLQCLTDNAC GWCSLKSQCM LKTVNETETC STHQVDKNST
HFLWEYLINQ PGHCANCSNY VSCEECIKSG LCEWWAEEAR CARLGKSENS VTSLSKCPVQ
CRLRRNCHDC LNERGRCVWC EARAACFSFA VYTSEYQFGM CREWLDQSVT PQLTDDSSVI
GHGNRNSIIG SLSPTHHHPP VTPKQQCKSC TQYNNCSTCL RTLSCGWCFD RDNPIEGICM
QGDFSHPFGN CSLALNSSSI HDAEWAYAQC PDVDECGLGL HDCHKEAKCT NTHGSYNCHC
RRGFVGDGRL TCMRTCFEFC VNGYCSGAPD YTCKCELGWT GADCSINCGC HNHSTCTERV
GKCDSCQAWT EGERCERCRQ GSYGNATSAA GCSPCECNGH GNQDLGICNV GNGECFCKDN
TVGVKCDQCA IGYYGDPRDG GQCYYQCESR GVLQNIGRSG IGSYQSYKSP WGTSLEVREC
LWILFPKTLE AEKSLLQVEF EWSTLAMDCD DNAVYIYDSL PDLTGATHQN QLISVVCNPY
TSSHIIEARS SHVTVYYKQG GGLFKHFGFN AIYTVKNCVA RTCLHPHICD EQHRCICPAG
YVGPRCEVEV CPRNCNAKRM QGYCDTDYGR CICNFGYGGM DCGTLVKPNQ LTVTELFNTM
LLSESFEHLR KTIPRFGHTV CADRRGSVWM FGGYSPSHGP LNDFRQFDTK NGTWMQVTVE
STPEEKMPLG RYFHAAEIYL KKQTIFIYGG ITTGSSSPNP QILEDFWQFS IQNQRWSEMD
LQGHRVRPPP LVGHTLTYTR EALLLIGGLT RNRSRQLELW EFNLETFRWE QLLALGVRMP
VLYGHSSVYH SEKHIMYVFG GYSIEPQNKL YALHLQKMTW TELPPFQDLN RPESLLPRAR
YFHSAATTEH YMVIYGGRTH PYNASDVLIA YVYNCNQWIR LTEDVNIVGR LQSSTYAEDI
SIDHENNAIY VIGGWDGSAS ASQVTKIVLP LDICQLWSSG KYLCRHYMGC SFCNVPGPYR
TTSHCFSQGN SGVCDNGNGT LTYNNGAACD DAWMARRNCS SFTTCSSCLA SWPTHVETTP
ICQWCDECGI KGRCVPAGVD CERRNTWCSK EVSVGLLNLC PQPQCHTLHC ETCILNDNCE
WAQNELGTIE CITKELVEQN QYRIIGQCPA SCYTYTNCTS CLNNDDADQP RDCKWSTMLN
TCLSPQTQPL FCAGGVCGLV LEANETDQCP EPCYVYSQCS TCLEHAHCGW CARDGYNGDG
ICTEGSPENK QEYPSVSTCD LIYTSRRNDS RLNPTDIVSW NYVKCPAENE CTNGHHNCDP
TSERCIDAPT GYRCVCGEGY RDDNGTCMPV CTQGCVRGNC LRPNICECDF GYVGENCSIQ
CLCNGHSNCK GPDLLDECVQ CHNNTMGAQC EKCQPLYVGD PREGRECIPC HEYCNGHTDA
CIANDSDPAF FNMTRAELNA TLPEGPLANA TCLRCANNTA GQRCDTCIVG YFRGSEDHRK
ECRSCQCHGH GNVCDPVTGE KCNCGNNTES DATCTAGGGK NSAHLCWSVQ CSKCRDSYAG
NPIDGHQCYK QITVESRMCF DAKPIEECKA KPAALKPGQT VFFVIQPRFM NVDIRVIIDV
TQGELDVYMS PQDDSFIVET NETTGYHEIY LDNRYNWGPT SKRSHSLNVA LPKHDNSTSF
SKLIMSDKRS SYYVPHIQDC KSHGGHSFYV KDQHAKDLST HVTLNQCNTL LRLFGLKNRL
VLTLPQHAHN LSATRFFIAL RASSGPEPSY GSVVFRQDQL HIDLFVFFSV FFSCFFLFLA
VCVVVWKVKQ AADIRRARRQ HVVELLHLAK RPFAHVFLAP NSFDIDSPNP TTSTSNRVVR
SATGARSRHY NVTAHSQLSE VMLIAIEPTF DNLAAVGTVF ISLPGRYKAP LSMTLGSTLI
TYPRSYPVSN RNFMRSHRGS SVPSIGLGGG IAMNPLPA
//
