ID   A0A1A9ZD22_GLOPL        Unreviewed;       745 AA.
AC   A0A1A9ZD22;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=FZ domain-containing protein {ECO:0000259|PROSITE:PS50038};
OS   Glossina pallidipes (Tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=7398 {ECO:0000313|EnsemblMetazoa:GPAI010973-PA, ECO:0000313|Proteomes:UP000092445};
RN   [1] {ECO:0000313|Proteomes:UP000092445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GPAI010973-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPAI010973-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   AlphaFoldDB; A0A1A9ZD22; -.
DR   STRING; 7398.A0A1A9ZD22; -.
DR   EnsemblMetazoa; GPAI010973-RA; GPAI010973-PA; GPAI010973.
DR   VEuPathDB; VectorBase:GPAI010973; -.
DR   Proteomes; UP000092445; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd07066; CRD_FZ; 1.
DR   CDD; cd00112; LDLa; 3.
DR   Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR   InterPro; IPR020067; Frizzled_dom.
DR   InterPro; IPR036790; Frizzled_dom_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   PANTHER; PTHR24270:SF65; FI24007P1; 1.
DR   PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR   Pfam; PF01392; Fz; 1.
DR   Pfam; PF00057; Ldl_recept_a; 3.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00063; FRI; 1.
DR   SMART; SM00192; LDLa; 3.
DR   SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR   SUPFAM; SSF57424; LDL receptor-like module; 3.
DR   PROSITE; PS50038; FZ; 1.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 3.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        128..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          334..458
FT                   /note="FZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50038"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          42..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          705..745
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        705..732
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        379..417
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT   DISULFID        455..467
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        462..480
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        474..489
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        513..528
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        643..655
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        650..668
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        662..677
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   745 AA;  83818 MW;  94C73C2038F955F5 CRC64;
     MSSEQIDLSG RPPPPVKGLR RQPTKYPHGL CVNIQSLSSD DERSVNYSRA STLRQSPNND
     NNQPSGKYQL NGNANDSDNL THLQVQPYKY PLTDNYSKTS HAQSDISKSS LLILDYAKDY
     CKWKCLRWPL IFFASVLIFF GLITYCIWLH DVSVARERYL QFRQHFADTT KSDNLSITTS
     TDATDSLTNP TTENRNHGLR ESTILRAIGT RARNSPREQK LTTVDYSHTK GAGDWIKHQP
     GDEETFVEST TLISEEAALA PVNVIRFTSG HQNSFGVPIE DDERILRLLN GLFSSNEPST
     IPTKAAMVKV SPTIPPLKRD KSTDPTVPLT KSYIQDNRCY STSLEMCQGV LDYDLTYNTS
     YQLTESELQD YQSLVQSNCS VRAIEFICAV LQPECRPSHI GVLPPCRRIC KAVLEACSEI
     IANSDTLTAT FDCSLYPDSN DFLRCEDSTR RRGYCYANEF ECYDRSCIPL QWQCDNIKDC
     AAGEDESECL ICDQPDEFRC RSNEKCIPGS ARCNLSYDCF DGSDEDDCSG YDANNSQGLE
     FDEADLNSFP RVFSYASFLS PNQTNNNFTY FTAHMDDESV NFRDSKEIMM TSDTENKFKY
     SSTNTNRSSS KYSANTTPLK PLNTRTLAAI STTETTKAPS TSCGLHHLRC VSGQCITVDQ
     LCDKKKDCPD GFDELMCIYK DNAEVTTTKK YNNFMLATSI ATSTSSSNLA NNNNNNNTSN
     NNNNNTLRND KRTIRTTTIK RKLKT
//