ID   A0A1A9ZJR4_GLOPL        Unreviewed;       514 AA.
AC   A0A1A9ZJR4;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Complex I-49kD {ECO:0000256|ARBA:ARBA00030505};
DE   AltName: Full=NADH-ubiquinone oxidoreductase 49 kDa subunit {ECO:0000256|ARBA:ARBA00031562};
OS   Glossina pallidipes (Tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=7398 {ECO:0000313|EnsemblMetazoa:GPAI016972-PA, ECO:0000313|Proteomes:UP000092445};
RN   [1] {ECO:0000313|Proteomes:UP000092445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GPAI016972-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPAI016972-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the complex I 49 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00005769, ECO:0000256|RuleBase:RU003685}.
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DR   AlphaFoldDB; A0A1A9ZJR4; -.
DR   STRING; 7398.A0A1A9ZJR4; -.
DR   EnsemblMetazoa; GPAI016972-RA; GPAI016972-PA; GPAI016972.
DR   VEuPathDB; VectorBase:GPAI016972; -.
DR   Proteomes; UP000092445; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 1.
DR   HAMAP; MF_01358; NDH1_NuoD; 1.
DR   InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR   InterPro; IPR014029; NADH_UbQ_OxRdtase_49kDa_CS.
DR   InterPro; IPR022885; NDH1_su_D/H.
DR   InterPro; IPR029014; NiFe-Hase_large.
DR   NCBIfam; TIGR01962; NuoD; 1.
DR   PANTHER; PTHR11993:SF10; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11993; NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT; 1.
DR   Pfam; PF00346; Complex1_49kDa; 1.
DR   SUPFAM; SSF56762; HydB/Nqo4-like; 1.
DR   PROSITE; PS00535; COMPLEX1_49K; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003685};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU003685};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003685}.
FT   DOMAIN          244..514
FT                   /note="NADH-quinone oxidoreductase subunit D"
FT                   /evidence="ECO:0000259|Pfam:PF00346"
SQ   SEQUENCE   514 AA;  59156 MW;  24497117B8D6FDD6 CRC64;
     MSKIVNKFKN WSRILLSSRG ALKIKDWSNL QITKQIRTSQ KWGLAAKTKF FKLAMSLLFS
     KYRQQKPHCV EEKKEEIKEN KPEKRAWYPD PEFLKQFSGT VMYPQGDEWK KKPLFKGPAT
     NFVEPKNFCT TFINFGPAHP AAHGVLRMII ELDNETVVSA DSHIGLLHRG TEKLIEYKSY
     LQSLPYFDRL DYVSCMSNEL CYAMAIEKLL GIKVPRRAQY IRTMFSEIMR LTNHTVAVTT
     AILDCGGMTP LFWQFEEREK LYEFCERASG ARMHTAYIRP GGVAWDIPLG FCDDLNDFCS
     KFVERIDELE DLITENRIWK MRTVGIGSLS AHDAINYGCS GAVLRATGVK WDLRKTQPYD
     AYPEVDFDVP IGKNGDCYDR YLVRVQEMRE AVRIIQQCLN KMPSGEVKID DHKITPPKRY
     EMKKGMEDLI HHFKYFSQGI IVPPGQTYTA VESPKGEFAV YLVSDGTSRP YRCKIRAASY
     PHLALMDKLT KRHLLADLVA IIGSLDIVFG EIDR
//