ID   A0A1A9ZLV8_GLOPL        Unreviewed;       691 AA.
AC   A0A1A9ZLV8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE   AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
OS   Glossina pallidipes (Tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=7398 {ECO:0000313|EnsemblMetazoa:GPAI018671-PA, ECO:0000313|Proteomes:UP000092445};
RN   [1] {ECO:0000313|Proteomes:UP000092445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GPAI018671-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPAI018671-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC       {ECO:0000256|ARBA:ARBA00007878}.
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DR   AlphaFoldDB; A0A1A9ZLV8; -.
DR   STRING; 7398.A0A1A9ZLV8; -.
DR   EnsemblMetazoa; GPAI018671-RA; GPAI018671-PA; GPAI018671.
DR   VEuPathDB; VectorBase:GPAI018671; -.
DR   Proteomes; UP000092445; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   CDD; cd11558; W2_eIF2B_epsilon; 1.
DR   Gene3D; 1.25.40.180; -; 1.
DR   Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR003307; W2_domain.
DR   InterPro; IPR044123; W2_eIF2B_epsilon.
DR   PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   PROSITE; PS51363; W2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT   DOMAIN          523..689
FT                   /note="W2"
FT                   /evidence="ECO:0000259|PROSITE:PS51363"
SQ   SEQUENCE   691 AA;  78615 MW;  302B90FABEB126E1 CRC64;
     MYFLFVFFFL FVFDCRVYLH LIHLLTMKKF MNKEIVQAIL IADNNAKNFR PFSETESVAL
     LPMVNVPMLD YALEALNRSG VMEVFIFSSL HYENVKGFIN FVYLLGKNVV LLLRESLASP
     SCWAIGMTVD VIGGEGCRCF GDAMRELDSK GLIRGNFILL DANCVTNADL KFILAQHKKT
     VAYDKGAVAT LIFKQANIHV RTGSEVMIAM DTQNKRLHHY QELSVDSKEI NFEIPLEVFT
     HNSEIALLNL VNPEIAIGSP SMLSLFSDNF DFETRADFIR GILINEEILD SRIYISLLPR
     QHYARKVNNW LSYQIVSNDI INRWTYPLVP DMGIKCLTQQ YIFLKNNIYR SATANLVKVG
     LRENVVIGNK SAVGLGSHLD CSVIGRNVLI GQNCRLHYVF IFDNVIVEDN CALEFCTIGS
     CSKIAANCEL KGVLVDYNCV IPKNTKLMKS QVFSSPLKNG KDKMRKISEK AYVIDDGAEV
     ADDEDERNHP ASPKMGKLTT IIADSDYSCS SDESESRGCS PILDDANGFL SEVIDSLTRG
     LQEKSNPEYL KLEINSSRYA YNMSLREVNF NVVKAIFNLP PIKEPSRNIS VALNTVFDQL
     KPIITHYIRT DDAMMDCLKA LEDIFEENEF VRSRMSQVVH YLYDKDFITE DVILTWYEQL
     DNDQHKILKQ TLQKFIEWLE QSSDGDNEET D
//