ID   A0A1A9ZPA0_GLOPL        Unreviewed;       955 AA.
AC   A0A1A9ZPA0;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Macoilin {ECO:0008006|Google:ProtNLM};
OS   Glossina pallidipes (Tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=7398 {ECO:0000313|EnsemblMetazoa:GPAI020773-PA, ECO:0000313|Proteomes:UP000092445};
RN   [1] {ECO:0000313|Proteomes:UP000092445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GPAI020773-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPAI020773-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC       {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004232}. Rough endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004269}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004269}.
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DR   AlphaFoldDB; A0A1A9ZPA0; -.
DR   STRING; 7398.A0A1A9ZPA0; -.
DR   EnsemblMetazoa; GPAI020773-RA; GPAI020773-PA; GPAI020773.
DR   VEuPathDB; VectorBase:GPAI020773; -.
DR   Proteomes; UP000092445; Unassembled WGS sequence.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0023041; P:neuronal signal transduction; IEA:InterPro.
DR   InterPro; IPR019130; Macoilin.
DR   PANTHER; PTHR13289:SF6; MACOILIN; 1.
DR   PANTHER; PTHR13289; PROTEIN PHOSPHATASE 1-BINDING PROTEIN BIFOCAL; 1.
DR   Pfam; PF09726; Macoilin; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        75..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        131..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          307..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          436..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          915..955
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          616..726
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          786..813
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        329..359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        436..458
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        459..505
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..524
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        530..559
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   955 AA;  105991 MW;  22B942FA71638C39 CRC64;
     MKRRNADCGK LRRPIKRNKI TESMYGSTTV LYMKFLVLWA IVITADFMFM FRFEFLWPFW
     LLLRSVHDSF KYKGLAFSVL FVCIAITSDL VCLFFVPVHW LLFVASTYVW VQYVWHTGEC
     EGPILNGKEL WMNLCFTDKG ICLPTIILWM LFVYLEAGIR WKDSRHIPHL DLCRPFAAHC
     IGYPVVTLGF GFKSYVGYRM RQRKQREVAK ENEFYMQLLQ QALPQEEHAL PTEECANAIA
     TTAAVTSNNL AVTVTAANGT QNNAAQNHHH NSAGNGNSNV LTASAALLTH TQIGNSTVAA
     NGGTLIQQQQ AQQAQNHHHQ HQQQEQHHHN HNNGVASSSS NTLPSSTSST IASPSATATT
     ITRTTTNATL NCTLTSFNND DKSYVQIGGG GSSNSIGEDS HTKSNKKPFC AATTFGINGN
     LATSTHPELD DIVAIEPVEK SKGRRNRSKK ENASKDTHHH TNNNNNNNSN NNNNNNNNNN
     NNNNNNTQHN TSSSIHNSSS NKDHHISQTN NHHPHHQQQI HHNHSHQHHY SDASSVSSAS
     SATSTTSHSS SSANSGNSAT STITHLASKV VAKICESCLK LETDVKKYRS EILHMKQIEN
     ELRQKLDNNL TTKSCLLAKH KECDELEKRI HELTNARHGD MLQLQTFERR LQEERRQKQS
     LDAQLNNEKK ARKMAEEKAA RPECSTMCKQ RRQQMDEDIK QLRRDLKIAE EAKQLAEQHG
     RKWEQEVRMF EAEIRNRDSI QPGTDVLMNA LAAMQDKNST LEKNLSAETR VKLDLFSALG
     DAKRQLEISE SLRRSKEDEI HDLKAKIAQL LAVMPTDSLC LPACSSTGAS SMLRMNDTPP
     LQTGQGPASP MLTSLQSAAQ QQQLSSRVAP TSGAEYVQQT ITSEYVTNQQ QQQQQCAGVV
     PVSVATSVLV SGTQVTNGVG NTNASNLDPN ATVYTPKGGQ NNNPGSSVVV GGAND
//