ID   A0A1A9ZUE7_GLOPL        Unreviewed;       858 AA.
AC   A0A1A9ZUE7;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Dynein heavy chain coiled coil stalk domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Glossina pallidipes (Tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=7398 {ECO:0000313|EnsemblMetazoa:GPAI025418-PA, ECO:0000313|Proteomes:UP000092445};
RN   [1] {ECO:0000313|Proteomes:UP000092445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GPAI025418-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPAI025418-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   AlphaFoldDB; A0A1A9ZUE7; -.
DR   STRING; 7398.A0A1A9ZUE7; -.
DR   EnsemblMetazoa; GPAI025418-RA; GPAI025418-PA; GPAI025418.
DR   VEuPathDB; VectorBase:GPAI025418; -.
DR   Proteomes; UP000092445; Unassembled WGS sequence.
DR   GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46961:SF8; DYNEIN AXONEMAL HEAVY CHAIN 3; 1.
DR   PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF12777; MT; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        826..844
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          80..360
FT                   /note="Dynein heavy chain AAA module D4"
FT                   /evidence="ECO:0000259|Pfam:PF12780"
FT   DOMAIN          375..711
FT                   /note="Dynein heavy chain coiled coil stalk"
FT                   /evidence="ECO:0000259|Pfam:PF12777"
FT   DOMAIN          725..803
FT                   /note="Dynein heavy chain ATP-binding dynein motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12781"
FT   COILED          600..665
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   858 AA;  97240 MW;  668368191F88DBF2 CRC64;
     MVTYACKTNL RFTLEQAFME RMENPGGKVT AMDLRNLFFG NYIDPDAEPK IYDEVMSYNK
     LEKLMHYYLK DYNAFSNSPM DLVLFRFAIE HISRVSRVLQ MPRGNVLMVG MGGSGRRSSC
     RLAAHIADCR LWTVQVTKTY TTQDWRDDLK KILLSAGFNL NHTVFLFSDS QATDEAYVED
     INGILNCGDL PNLYQLEDKA AIMENMTSVA KQLGKVVDPL PSEMYAFFID RVREQLHVAL
     AFSPIGESFK ERIRMYMPWP VDALQRVAEY FISSMNLHQP EETEEQVETD VKSRESAESE
     KSLEEVQEII LSDLENELVQ VVMHFNRSVV AASEKCYTEL SRRNYVTPSS YLEMLKAFRS
     FYKRKLEEIT RLRDRYTTGL EKLDFAAAQV GEMQANLYEL QPKLKVLSEE TERIMVNIER
     ETAEAEKKKE IVGADEAAAN EAAAAAQAIK DDCESDLAEA IPALEAALDA LNTLKPADII
     IVKSMKSPPY SVKLTLEAVC VLKGIKPDRK PDASGRMVED YWAVSLRMVS DMKFLESLKT
     FDKDNISPLI MKKIRERYVA DRDFVPEKIK SASTACEGLC RWVLAMDVYD KVARIVMPKK
     AALAEAENDL ASQMEKLNAK RAELQIILDK LQKLNDFFAE KSRQKKGLED EIENCEKKLN
     RAEKLLGGLG GEKTRWGEAA QSLHKSISNI VGDVLLAGGC TAYLGFFPTE KFSLASTLGN
     PMQIRAWSLA GLPSDNFSVE NAIIVSNSNR YSLLIDPQVQ ANKWIKNMEK KNSLKVIKQS
     DANYMQVLEL CITYGTPVLI ENLFIASCSQ IHFGIQWFSF LSDYKVLFFV LLLFLLLSYF
     HGLLNESTAN LLKITSKG
//