ID A0A1A9ZVI6_GLOPL Unreviewed; 633 AA.
AC A0A1A9ZVI6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
OS Glossina pallidipes (Tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=7398 {ECO:0000313|EnsemblMetazoa:GPAI026351-PA, ECO:0000313|Proteomes:UP000092445};
RN [1] {ECO:0000313|Proteomes:UP000092445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GPAI026351-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPAI026351-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; A0A1A9ZVI6; -.
DR STRING; 7398.A0A1A9ZVI6; -.
DR EnsemblMetazoa; GPAI026351-RA; GPAI026351-PA; GPAI026351.
DR VEuPathDB; VectorBase:GPAI026351; -.
DR Proteomes; UP000092445; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR013587; Nitrate/nitrite_sensing.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR11920:SF504; GUANYLATE CYCLASE; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF08376; NIT; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 419..548
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 633 AA; 71563 MW; 08DE429536F9983D CRC64;
MSVHSISSED ISTAVEAKCC SAEARNPAIK TGRRLQLMQM IILPFIPILA LIVQTSVTLQ
EILDYKAEVA DIEAQVTIAT DLGKVVTRLQ LERSEVAFFI FANGSEERSN LAQRFKVTDQ
ALNNMTTWSE VSVPTSPDDD DEEVLLNRTE FQNRLNEFRE RILSEPEDNS VTDVMNWYTS
INKALLHHLS EQIKEADNSG VWRYLVGFKN LLKSIECQNI ASSFGIKYYG RGFLGSDAFV
SYIRYDFLAR ELINSTLNYV PSLKPMYANI TKTAKYKKMK RMSAIVLKNK PNVADKQNAM
EYYDSMHNYT DDLRILQKDL RYKIKEYVDS TLYEAANKEA IGIAILVVVL CVSPVIIILV
KNAAATIQMY ALNLAQKAKE LKREKRKSDS LLFQMLPPSV AMQLKHTQQV PAELYESVTI
YFSDIVGFTE IAARCTPLEV VTFLNSIYRV FDERIECYDV YKVETIGDSY MVASGLPVKN
GNKHVCEIAT MALDLLDAST FFKIPRSTES LQIRCGAHTG PVVAGIVGTK MPRYCLFGDT
VNTASRMEST GEAHKIHITE EMNGSLMRIG GFKTEHRGLI DVKGKGLMST YWLTCKDGPV
KIREEISWFA DMQPVFLENL KLETPYKSSK QKK
//
