ID   A0A1A9ZXL8_GLOPL        Unreviewed;       282 AA.
AC   A0A1A9ZXL8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=3'-5' exonuclease {ECO:0000256|ARBA:ARBA00040531};
DE   AltName: Full=Werner Syndrome-like exonuclease {ECO:0000256|ARBA:ARBA00042761};
OS   Glossina pallidipes (Tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=7398 {ECO:0000313|EnsemblMetazoa:GPAI028276-PA, ECO:0000313|Proteomes:UP000092445};
RN   [1] {ECO:0000313|Proteomes:UP000092445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GPAI028276-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPAI028276-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the WRNexo family.
CC       {ECO:0000256|ARBA:ARBA00037949}.
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DR   AlphaFoldDB; A0A1A9ZXL8; -.
DR   STRING; 7398.A0A1A9ZXL8; -.
DR   EnsemblMetazoa; GPAI028276-RA; GPAI028276-PA; GPAI028276.
DR   VEuPathDB; VectorBase:GPAI028276; -.
DR   Proteomes; UP000092445; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR   CDD; cd06141; WRN_exo; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR13620; 3-5 EXONUCLEASE; 1.
DR   PANTHER; PTHR13620:SF109; WERNER SYNDROME-LIKE EXONUCLEASE; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722}.
FT   DOMAIN          72..251
FT                   /note="3'-5' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00474"
SQ   SEQUENCE   282 AA;  32810 MW;  7B28BC7AC329C0C7 CRC64;
     MTESQLNKLE VSKNAEIQTQ CSYKLIFDKA METFKRRSDR LMNRCEKHNH IEKKISSFVK
     YEGKIVYLTN VCEIAEAADS LIQWVEGQHI PVPLSFDMEW PFSFKTGPGK TSVVQVCLEL
     NCCYVFQLSN LRKLPAALVA LLKHPRVRLH GVNIKNDFQK LARDFPEMKL DDLKQRCIDL
     GTWCNEINET GSRWSLDRLC NYLTNQTVDK NKRVRMSNWH VVPLNHDQLM YAAIDVYIGL
     VIYRELENRA RIKKEKENEF VQNNGCAAFK AVKALGKNFL ME
//