ID A0A1A9ZY02_GLOPL Unreviewed; 1174 AA.
AC A0A1A9ZY02;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Glossina pallidipes (Tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=7398 {ECO:0000313|EnsemblMetazoa:GPAI028551-PA, ECO:0000313|Proteomes:UP000092445};
RN [1] {ECO:0000313|Proteomes:UP000092445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GPAI028551-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPAI028551-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A1A9ZY02; -.
DR STRING; 7398.A0A1A9ZY02; -.
DR EnsemblMetazoa; GPAI028551-RA; GPAI028551-PA; GPAI028551.
DR VEuPathDB; VectorBase:GPAI028551; -.
DR Proteomes; UP000092445; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08834; ArfGap_ASAP; 1.
DR CDD; cd07604; BAR_ASAPs; 1.
DR CDD; cd13251; PH_ASAP; 1.
DR CDD; cd11821; SH3_ASAP; 1.
DR Gene3D; 1.25.40.950; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR035836; ASAP1-like_SH3.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45854:SF3; ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 324..418
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 441..561
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 645..677
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1110..1174
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 714..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1174 AA; 130022 MW; 8E4AAC6DD38E8CF4 CRC64;
MPPALIGIAE FVEETRDDYN SPTTSTFASR MPDCRQTISV LEERLEFDRE GLAKLKKAVK
AIYNSGNTHV DNEMFLVRAL ERLGSKVMDQ DEPDIGAAFL KFSVVTKELS ALMKTLMQNI
NNIVMFPVDS ILKSELRGVK GEMKRPFDKA AKDYEAKFIK IEKEKKAQAK EAGMVRTEID
AAVVADEMEK ERRLYQLQTC EYLLKYKEIK TKTGIELLQH FIEYYHALNN YFKDGLQTIE
HFGTYISDLS EKLQKIKQRQ EEDRRSLLEL RTLLRSAPDF ERVDNLPVTD KGGGGGSGSC
GLGLGGGGNL GYSLHQLQGD KHHGVTRSGH LLKKSEGKVR RVWQKRRCRV TGDGFLDICH
ADESKPPTRV NLLTCQIKPV PDDKRGFDLI SYNRPYHFQA EDEADQRAWM AVLVNCKEKA
LAKAFQHANP QMSPSLVELQ KTVIRYVQLL PGNDQCCDCG SRNDVTWISL NFGILVCIQC
SGVHRDLGVH HSRIQSLTLD NLTTANLLIA RAMGNHALNE IMEATLGKGK LAPDSTMEQR
YDFIRAKYVA KRYVMRTCAD ENDLRCDLEQ AVVNADLSQL LQVWAEGADF TCCLPSWDDG
ETALHLAVLR EMGSTLHIVD FLIQNMPPKG LNKATNPPSI LNMSGKNTSL HLCALHDRRE
CMKLLLRSGA DYEIRNSQNK NAIDIAKEMG HNMCKELIEC AMRREKSAFD HIQTDWNLPN
EDGSTDFSDD DTVIDERKSR SRPPSFAGGD SPILRSRSST CDSIQSSSSP IANCPSRQFT
LPMYQQSAGT SPKQQISLGQ YLGSAGNVNM ISSGSVSGAG GGSSPSSASS QSGRMAARCN
SEFGTGARKS TSTANMNSLK KRTAPAPPPG LSSTTTSSFY GTLPHPPRHS QTYDTNDVRT
HNNKNQSMDA SYGTLPHLRS VDSSPRIMHN SATASGHQVG FYERYDKLIS QDPGGPSCHI
MPAMTTFGHK RSPSGESLNR NLHLAGAKLV LPTSGEIPML KHVDKSSLIR PKIPPPGPPS
TEREIANGQS NKVFSSADEG PVAPPRKLMN QPTSYSDVET WHADMVSSGR IADNIGESTS
SCDNDHVASP TDNTLKLSNT TSNITKCNNS GHRRCRALYD CSADNDDELE FKEGEILIVL
NERTDDENWM EGIIEGDPTR HGMFPVSFVH MLPD
//
