ID A0A1B0A1A7_GLOPL Unreviewed; 2759 AA.
AC A0A1B0A1A7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 13-SEP-2023, entry version 32.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Glossina pallidipes (Tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=7398 {ECO:0000313|EnsemblMetazoa:GPAI031386-PA, ECO:0000313|Proteomes:UP000092445};
RN [1] {ECO:0000313|Proteomes:UP000092445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GPAI031386-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPAI031386-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 7398.A0A1B0A1A7; -.
DR EnsemblMetazoa; GPAI031386-RA; GPAI031386-PA; GPAI031386.
DR VEuPathDB; VectorBase:GPAI031386; -.
DR Proteomes; UP000092445; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR46848; REGULATOR OF G-PROTEIN SIGNALING 3; 1.
DR PANTHER; PTHR46848:SF1; REGULATOR OF G-PROTEIN SIGNALING 3; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
FT DOMAIN 247..325
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 439..622
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 214..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1290..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1329..1440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1564..1596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1795..1855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1945..2011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2043..2125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2382..2437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2552..2574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2708..2759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1329..1348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1840..1855
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1945..1978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1985..2006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2056..2071
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2080..2103
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2106..2120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2382..2397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2405..2419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2554..2574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2708..2722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2725..2739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2759 AA; 304061 MW; A82E66A9AE0BD486 CRC64;
MKAKKFFKLI FFVEHLSTNT FLCHLSRRHL ITYLKSFTLS QFFNSSVYLR LCCFFFFHYR
RSEFLGCMSF PLLTLLHQEI NGSYKLQSQE CVNKPQPAIP LIAAHHFYGN ILQHQQQYQQ
QQQQQQLSDQ QQQLPLNQNR ITAKATRITC SINMANTFTQ MRSNDDDVIS IDSMAQPLAV
GEQQAPMVLS KKALHQRDAD ENLFLRFLEL DPPNSTEAAT AGQATPAASD RRSSGSKPVG
RTPFTMTKKL TRTAERGFGF SIVWTHPPRV EKIEAGLSAD RSGILPGDYV IFVDKHNVVT
MPEADVLNLI RSQGATLTLE IFRRSGSGTA IGSAMGGGAA SAAGTSRSYA TNTLPMNGKM
SRIPSANSNY AASEEMCINA NNVTKRTIVA PAAAQPASVA RPPTACSMGT SSSIEAAKRR
LNLPQVTFSK ESIAPISDNR RKFLLQLISR EQNFMSALHF GMQRFVQPLQ ERKDLITPND
HRTLFQNIDE LLRISEDILE QLCHDDQEPQ MNFASRVYLS KTTAICAAYK KYCNGIKRAD
CVLVNKSRQT GSEFISFITE PPVPRKRPDL TMFIHRPLQH FREILKLMQL LASNCHVDTE
EHKNFTTVIS ELQAAYREIT VSSGLMEPLG EGRPLLTLQD LESRMVFTKC KPFTLAVQGR
QWIFGGDLSR VEGRSVKPYW TLLFSDIIVF AKVSRDRVLF ITEEPIPIAN IVDSCFHMRK
KTTEFRLTVD PNGRLAESPT GYCAPDLTKT PKKGARRKSL ILRAPSLELK AVWQNLLQRQ
IFLVNAALGS TPLSSPLDSP DVLNTLVPLS DIGVASASIG SIKLSSMDSI NIRNQHQQQQ
QQHQQVRLQR DSSKLLHGSD VSGSFENLQR LASTLASRCS TRMTQTTQAS VSCSSQTNSP
ASYRRSMGGV GNVACLGIPG DSVTSLRSFS CGRRHLFNPQ TLEGRPLSAA RSYNASNNNS
TNLLSCSGSS LNTQTLGSGD HVPSCKCLTS IPEASIETGN DSNYELKALL LRQNCSDNSS
SEERVLLIDS EGRCCLTSAS LFTFKQTDNN NLTTNLTLTE NSQKSSQKKL LEFSLSSVGR
SFIDESDVLQ DSMIHSLATP ETPTPNISPS VTKLTFKTHD LDTFSNDFVP QSPTNSAKEK
NLHANATTPT IPLAQFEIIL RVNYSNRLSN VSEQIEKLID EKCRFLNKTG TAKSSALHLA
NWMKGQLDKQ QEQARLAAAR SPETLGPEDE HILYTDSDQD ERITYWTRQQ LEKRTKELNL
VKENGYIHAK TNGLGKRLSG VEEISMSDNF SEGVSQSHST TSDSQQITVR SSPIVLDKLA
VCRHCHKNCQ QNQNSSPSAV EKSGVGQTQP SSPPPPCTKS IKTNLEDSSN TTGLISNSLK
VQHSQSSPNR CCKINGSGSR ASSVTSISSS TVTGEHPSER SSSKLIASSS KRETGDTESD
VAQLISDDVY QSEATDEGAL ASSISGSSGV EEVRKLITHN IHKLRILDEH NEANVLLNGH
YLGSGGGDEC TRNEKQQMEE EAAKLASPKR FRITPQVAKE VDENNELADQ EVLTTVTVTE
MATVVKNEPS SQTPKSPSKP QTPKPVKSPS KLSHSSDSPC KQFLPCNCPC RPADFANTTL
SPDELEHETC KLLESPRKSP VLTSNKQEDK LDELYENIHK NCKCICGGEE SEKIDPKEEE
NVDNHAIKGD SDEEEDLSLM LIGLAQLTPA AKLLNMKTPT APMPTPTTTS SCYIENGFVP
TIAVVPPTPD SVLTKTSTNV WDNSGTHMSV TTSTATNLLI SNVPRQAIIE NIPEDSCDES
PLDEEPPYRP MNTTLRRYGT MSSLERLPSE DRLEPSENMA EYQDDNEEDD DDDEELMDKA
RADNIELDNE IRVVTKALYN HRDNDDDDDD GDDDIDEEAD ELLSGAKSNG AAWASRASTF
VAGKMSFFEE SRAFIDKYLG RWNQDHSSSS IQNNNSETDE QMDECTSGAT SGEEVWGTPT
SGGDNDELHL ANSENTHSSP TKSSNSLNDD DDTELMMDEL LMAPPMTAST IRGLLPRRRL
EPLFEEETES DEEKTQQESE ELKKGETTTN GHYLEDSEAG SSSDEDAANE ADYDEEDEED
LTSTEDRLQP NLQTTILGPR PLRNPTVEHS LPSTVLKASS CEYLLEPRAP KPLITSAPIN
SNDLATAYNS ETVTPIISSM TLTMTMTTTS TTDKDVSMKV TAATTQSLVH SQTSTTISNV
NVTIKQEKDD CYSRIEEVAK NKTTSRPAKF IPPPPPPRRL LLTRTNLKTG GAYTATTKAV
SVVFFQFIYL FTLSKIIYIS QPLPPVRSGV SADNGYLAGA DESVDPTVGI MNVTPAPKMT
PRKSQRLDVC NIKTSEENTE VTKVRPSSTI IETSLLGMVE KKPISTSSTT VSMTNEKGKV
PQPKPRQTKQ PTQATDISNR GDERTTKSPC ALAGVGSGLS PRLEMRLALN HDILGDEDLI
CYDPGPDLTT ILGHDLSTFH RLTGRDLLNR SATNRVQPKE AVISYSQQRN SKMDTPTVNR
RTRTSLQLQQ QTLTTAVSAT PFVGSARVGG VPQHLQPNRN TWSNSASAVP SRDGNANVAA
NCKDYSYSSD ENKLSDLEIL ARREKIYCMS QLKSGSLART GTATTTMTTS MTATMKSNNL
SSSSQALAMM TMTTTTTEDV NEGASQRTRK LVRDETALMD FSKANKLFNF IKRRNSELSS
SANCSQISLN DSNANSTPVH RGSPVSPRKD NDKPSLNRRL WKHLTKRRRA NSVSEIAAS
//
