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Database: UniProt
Entry: A0A1B0AEK5_GLOPL
LinkDB: A0A1B0AEK5_GLOPL
Original site: A0A1B0AEK5_GLOPL 
ID   A0A1B0AEK5_GLOPL        Unreviewed;       499 AA.
AC   A0A1B0AEK5;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   03-JUL-2019, entry version 14.
DE   RecName: Full=Receptor protein serine/threonine kinase {ECO:0000256|SAAS:SAAS00138132};
DE            EC=2.7.11.30 {ECO:0000256|SAAS:SAAS00138132};
OS   Glossina pallidipes (Tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Hippoboscoidea; Glossinidae; Glossina.
OX   NCBI_TaxID=7398 {ECO:0000313|Proteomes:UP000092445, ECO:0000313|VectorBase:GPAI043256-PA};
RN   [1] {ECO:0000313|VectorBase:GPAI043256-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|VectorBase:GPAI043256-PA};
RA   Liu L., Yang H., Zhao H., Sun J.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000092445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|VectorBase:GPAI043256-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|VectorBase:GPAI043256-PA};
RG   VectorBase;
RL   Submitted (JUL-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
CC         phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
CC         COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.30;
CC         Evidence={ECO:0000256|SAAS:SAAS01128400};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-threonine + ATP = [receptor-
CC         protein]-O-phospho-L-threonine + ADP + H(+);
CC         Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-
CC         COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.30; Evidence={ECO:0000256|SAAS:SAAS01128404};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC       {ECO:0000256|RuleBase:RU000304}.
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DR   VectorBase; GPAI043256-RA; GPAI043256-PA; GPAI043256.
DR   Proteomes; UP000092445; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR000472; Activin_recp.
DR   InterPro; IPR003605; GS_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 1.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   SMART; SM00467; GS; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000304,
KW   ECO:0000256|SAAS:SAAS00138218};
KW   Complete proteome {ECO:0000313|Proteomes:UP000092445};
KW   Kinase {ECO:0000256|SAAS:SAAS00138139};
KW   Membrane {ECO:0000256|SAAS:SAAS00138203, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000304,
KW   ECO:0000256|SAAS:SAAS00138212};
KW   Receptor {ECO:0000256|SAAS:SAAS00138179};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092445};
KW   Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304,
KW   ECO:0000256|SAAS:SAAS00138186};
KW   Transferase {ECO:0000256|SAAS:SAAS00138167};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00138220,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00488859,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    116    141       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      160    190       GS. {ECO:0000259|PROSITE:PS51256}.
FT   DOMAIN      191    487       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
SQ   SEQUENCE   499 AA;  56243 MW;  7C6E05CB2395D84C CRC64;
     MKTRTLTCYC DGSCPNNVIN GTCETRPGGY CFSAVEEVYD EFTQTYEEER TFGCMPPEEN
     GGFLMCKVAA VPNLHGKNID CCNSGDLCNR HLHPAFTPKL TTPAPELPVS SQSVHYLAMI
     ASMIICLSAF VVIIVIVCMT YRRREKLRKQ PRLIGSMCNS QLSPLSQMVG QSSGSGSGLP
     LLVQRTIAKE IQMVRLIGKG RYSEVWLAQW RDEKVAVKTF KYTQETSWFR ETEIYQTVLM
     RHENILGFIA ADIKCNGSWA QMILITDYHE NGSLYDYLSS SVINPQKLHL LAYSLASGLA
     HLHEEIFGSP GKPAIAHRDI KSKNILVKRN GQCAIADFGL AVKYISELDE IHIAQNTRVG
     TRRYMAPEVL NQTMNPQQID EFKRADMYSV GLVLWEMARR CYTPIPGSKA TTCEDYAPPY
     HDVVPSEPTF EDMHVVVCVK GFRPPIPSRW QEDDVLATIA KIMQECWHPN PSVRLTALRV
     KKTLARFDAD YMDCPVKIV
//
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