ID   A0A1B0AK19_GLOPL        Unreviewed;       626 AA.
AC   A0A1B0AK19;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Rabphilin {ECO:0008006|Google:ProtNLM};
OS   Glossina pallidipes (Tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=7398 {ECO:0000313|EnsemblMetazoa:GPAI048254-PA, ECO:0000313|Proteomes:UP000092445};
RN   [1] {ECO:0000313|Proteomes:UP000092445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GPAI048254-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPAI048254-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A1B0AK19; -.
DR   STRING; 7398.A0A1B0AK19; -.
DR   EnsemblMetazoa; GPAI048254-RA; GPAI048254-PA; GPAI048254.
DR   VEuPathDB; VectorBase:GPAI048254; -.
DR   Proteomes; UP000092445; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   CDD; cd08384; C2B_Rabphilin_Doc2; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR041282; FYVE_2.
DR   InterPro; IPR010911; Rab_BD.
DR   InterPro; IPR043566; Rabphilin/DOC2/Noc2.
DR   InterPro; IPR001565; Synaptotagmin.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR45729:SF4; RAB EFFECTOR NOC2; 1.
DR   PANTHER; PTHR45729; RABPHILIN, ISOFORM A; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF02318; FYVE_2; 1.
DR   PRINTS; PR00360; C2DOMAIN.
DR   PRINTS; PR00399; SYNAPTOTAGMN.
DR   SMART; SM00239; C2; 2.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS50916; RABBD; 1.
DR   PROSITE; PS50178; ZF_FYVE; 1.
PE   4: Predicted;
KW   Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00091}.
FT   DOMAIN          14..138
FT                   /note="RabBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50916"
FT   DOMAIN          64..126
FT                   /note="FYVE-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50178"
FT   DOMAIN          341..466
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          484..617
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          164..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..217
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   626 AA;  71074 MW;  30E5FBF34DD3FE54 CRC64;
     MSLLSKLRTG WNSTTPQEPL KPEEQAAIIS VIQRNEEIES AERQRVGRLV ERVEKIKQKL
     NAVERGPNKC RLCGEAYGLI RPQRILCEDC RKVACPKCCL DINIRYHTVQ KNREIWLCRI
     CSETREMWKK TGAWFFKGIP NYEIPSSTSP TTLRNVSATV TDGLLLPPPS RIQGSNSSAH
     KEKIKKLTIH VRDSSSSEEE NDETEETKKP NSEKLNLKTK ESTMDGNNVI SKCVREGSYR
     LRSFVPIRNF IDVKSSSAPT VERKISNTFF FNNRMSFKTE SQKQQDCDGN SVVSEDNKME
     IFTNCGERRG SVTSTCTMSD SSSASSAILA NQLSSHCRDS LLGWLEVAMT YRENYNTLDA
     TVVRARDLLA MDSSGLADPY CKLNIITAEG KPKFIRWQRT RTVHKTCNPG FNETLQFVGV
     ESEELSNAML YVAIYDEDKY GNDFLGAAKI GLSSMSNAKQ YRSLVPLCGE DELSNSAESS
     QEWPHGKVLI SLCYNAKKRA LLVRVKQCIN LIPMDSNGSS DPFIKLQLKP DFHRNKKYKT
     SIKWRTLNPI YNEEFQFEAS PHDLNKQCLV LTVWDKDLGK SNDFLGSLVI GHNSKGERLQ
     QWLDCIRLPD HVHEKWHCLS GDNPLH
//