ID   A0A1B0ALM4_9MUSC        Unreviewed;       762 AA.
AC   A0A1B0ALM4;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Methoprene-tolerant {ECO:0008006|Google:ProtNLM};
OS   Glossina palpalis gambiensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=67801 {ECO:0000313|EnsemblMetazoa:GPPI000934-PA, ECO:0000313|Proteomes:UP000092460};
RN   [1] {ECO:0000313|Proteomes:UP000092460}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000092460};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GPPI000934-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPPI000934-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   EMBL; JXJN01000025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0ALM4; -.
DR   STRING; 67801.A0A1B0ALM4; -.
DR   EnsemblMetazoa; GPPI000934-RA; GPPI000934-PA; GPPI000934.
DR   VEuPathDB; VectorBase:GPPI000934; -.
DR   Proteomes; UP000092460; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR   CDD; cd11391; bHLH_PAS; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR001067; Nuc_translocat.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   PANTHER; PTHR23042; CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS; 1.
DR   PANTHER; PTHR23042:SF107; FI10506P-RELATED; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF14598; PAS_11; 1.
DR   PRINTS; PR00785; NCTRNSLOCATR.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
FT   DOMAIN          46..99
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          116..187
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          23..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          571..608
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        592..608
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   762 AA;  85749 MW;  2DB0F7D60989CE80 CRC64;
     MTTMSIHKII GAENVISTAI SEPETARLSS TPSPSTTEDG GVTIINGREA RNLAEKQRRD
     KLNASIGELA TMVPHVVDAQ RRMDKTAVLR FATHGLRLQY VFGKSAIRRN KIRGHDQLMT
     NALLQLLDSF LITLTCHGQI VLISSSVEHL LGHCQSDLYG QNILQITHPD DHNSLRQHLI
     PKDIENLFGV IQTSYHSQQR QPDQDPLEKI YCQNPFNQGN CDRINEKLRA DKRCFTVRLA
     RASTRSEARK VYEVVKIDGC FRRSDYSIAP SGSYPIVSQL IRRSRSNGNA PVIGGGAFIP
     HLMQHDAIAQ AALHGVSGND IVLVAMARII RPPKILNWPL DANRLEYKTR HLIDGRIIEC
     DQRISLVAGY LKDEVRNLSP FSFMHQDDVR WVIVALRQMY DCNSDYGESC FRLLSRNGNF
     IYMQTRGYLE IDKSTNKVHS FVCINTLLDE EDGRRKVQEM KNRFSIIINA KVPTNSVQDL
     PASQNPQQLE RIVLYLIEDL QKRQSSSCIV DEIHSNEECN NFNYSSTPPL ALVPPEPASV
     KSSISQSVSV VNITAAKNFH IKTKIDECRE AQWSDGDGDG DGDEANGESP MPVDSPTKQQ
     QSRATVLQMQ TKTSRIVDKD IVEKETAIPM ESSRSTVLKR FSTTADDSSI EHQPSKRILN
     TTVENPLTHS TSNHSGNSNT SDIHNFISTS LRHVCESLHR IDARTSTLRK QRSSLPSSID
     HKLDAIIIEQ QKQNEFLANI KTEYEEHVEE FSQSDEGLLS RL
//