ID A0A1B0AVZ8_9MUSC Unreviewed; 1059 AA.
AC A0A1B0AVZ8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
OS Glossina palpalis gambiensis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=67801 {ECO:0000313|EnsemblMetazoa:GPPI010448-PA, ECO:0000313|Proteomes:UP000092460};
RN [1] {ECO:0000313|Proteomes:UP000092460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000092460};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GPPI010448-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPPI010448-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; JXJN01004436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0AVZ8; -.
DR STRING; 67801.A0A1B0AVZ8; -.
DR EnsemblMetazoa; GPPI010448-RA; GPPI010448-PA; GPPI010448.
DR VEuPathDB; VectorBase:GPPI010448; -.
DR Proteomes; UP000092460; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 6.10.250.3140; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1740.100; Set2, Rpb1 interacting domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR038190; SRI_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF159; ATP-DEPENDENT DNA HELICASE Q5; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 35..210
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 248..401
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 720..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 958..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 772..812
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 731..750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..904
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1059 AA; 121287 MW; 2B6B353EA3D4198B CRC64;
MIKATDEIEA QLHDNLEKHF GYTEFKSDLQ KRAVKCAVKK KRDIYISMPT GSGKSLCFQL
PGLMSDGQIT IVFSPLLALI KDQVDHLAKW KISADSLNSK MTQKERERVV NDLKAIRPSI
RFLYITPEQA ATKGFQDLLR QLVEYDKIAY FAVDEAHCVS QWGHDFRPDY LRLGELRVKY
PKIVWMALTA TASKQVREDI CKQLQLNEPV AQFVTPSFRK NLFYDVVFKN SIEDDFQHLA
SFALHCLGDE DEYKETPPAQ RGCGIIYCRT RENVERVAYG VSRRGIAAMA YHAGLKASER
IEVQEKWMRG EYPIIVATNS FGMGVDKASV RFVIHWDVPQ NVAAYSQESG RAGRDGLKSY
CRLYYGREDA KSIRFLLQND INRFRNSTCS AKLDLAQRAM KNFDEIVAFC EMLQCRHKLF
SDYFGDPPPD CQKQCDVCKN PKKMEKALQT FQRLCMDSAL KTDISLEDSS DLYEGGRAGA
KRDAADYNEN CTDDDFSGDE TARNQLAKKA KRETEDFIRK QFQLRKCLSA AKELENEPCT
AMTRVHQAQA TNTKVAGLKI SIRENYLTAL TDALKQNVQN SNEDKPKNDL AQRDYQAVAA
DLEYECFSKQ KIASMYRHSM AKQLSAIKQM TSQKRLLPIL MTFEPKPQAK PIFYNGGSVE
YFERKLKELE EQKPQSMVSK KDLPKSLRVR KSFKQEMSKQ TSIENYFNKA LIKTETEDEL
SNASSESKEI GGFNVKKESK NETADVSERK DIEEDLKKPI MNDGKEEDLI GKAELIENIL
ECENKEDNLE SLLSKERELK MEIENLEKVD SEEDYKYRDP CGEDSQHDFN DNRKILSYEE
TLFTKPSTST LNYSVSGTHL KAKRTSHYNK SHHLATTTNQ SVDKLKNHAS TSDCKKDSHS
GGKQLLNLDH HINTNSSSSR EQSSAKEKSL WPAVHQTHSS HSRVKEYLEK NAASFKTKLS
HHISSSNSTH PKSKAQSERE TAFKHKTDVS KSVVDYLNPY YKRKIATKEL FKILAKRITN
RVIDGNLASD DWKSQIKNTF HNLKMISEDS DIEKYFPVT
//
