ID A0A1B0AWJ2_9MUSC Unreviewed; 293 AA.
AC A0A1B0AWJ2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=ER membrane protein complex subunit 2 {ECO:0000256|RuleBase:RU367091};
OS Glossina palpalis gambiensis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=67801 {ECO:0000313|EnsemblMetazoa:GPPI011191-PA, ECO:0000313|Proteomes:UP000092460};
RN [1] {ECO:0000313|Proteomes:UP000092460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000092460};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GPPI011191-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPPI011191-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Part of the endoplasmic reticulum membrane protein complex
CC (EMC) that enables the energy-independent insertion into endoplasmic
CC reticulum membranes of newly synthesized membrane proteins.
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU367091}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU367091}; Cytoplasmic side
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SIMILARITY: Belongs to the EMC2 family. {ECO:0000256|ARBA:ARBA00010361,
CC ECO:0000256|RuleBase:RU367091}.
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DR EMBL; JXJN01004809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0AWJ2; -.
DR STRING; 67801.A0A1B0AWJ2; -.
DR EnsemblMetazoa; GPPI011191-RA; GPPI011191-PA; GPPI011191.
DR VEuPathDB; VectorBase:GPPI011191; -.
DR Proteomes; UP000092460; Unassembled WGS sequence.
DR GO; GO:0072546; C:EMC complex; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR039856; EMC2-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12760:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR12760; TETRATRICOPEPTIDE REPEAT PROTEIN; 1.
DR Pfam; PF07719; TPR_2; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU367091};
KW Membrane {ECO:0000256|RuleBase:RU367091};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 153..186
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 293 AA; 33857 MW; 8743057C6F9C906A CRC64;
MSLNYEEMCW KDVRDYFRKW REDNERRSDD VIQLWEAVLE DKVIKTGNEK NLILEQVIVA
ALDTARFDIA GKCIKELSSE FPGSLRVMKF KAMRLEAMER YNDALEVLDA IIAKDETNAA
PRKRKVAILK AKGRRIEAIK ELNEYLKKFM SDQEAWHELC NLYLAEGDYA KAAFCMEEVL
LHNPHSHLIH QRLAEIRYTM GGMDNIELAR TYFSQAIKLN PKNLRALYGF YLCCTMIANS
RAVGTKRKEA QKMAQWALNQ TSVLTAKRST IENNEELIDA LEGAFANLDV KSM
//
