ID   A0A1B0AY35_9MUSC        Unreviewed;       378 AA.
AC   A0A1B0AY35;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0000259|PROSITE:PS50261};
OS   Glossina palpalis gambiensis.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=67801 {ECO:0000313|EnsemblMetazoa:GPPI012578-PA, ECO:0000313|Proteomes:UP000092460};
RN   [1] {ECO:0000313|Proteomes:UP000092460}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAEA {ECO:0000313|Proteomes:UP000092460};
RA   Aksoy S., Warren W., Wilson R.K.;
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GPPI012578-PA}
RP   IDENTIFICATION.
RC   STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPPI012578-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. Mth
CC       subfamily. {ECO:0000256|ARBA:ARBA00008979}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JXJN01005524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0AY35; -.
DR   STRING; 67801.A0A1B0AY35; -.
DR   EnsemblMetazoa; GPPI012578-RA; GPPI012578-PA; GPPI012578.
DR   VEuPathDB; VectorBase:GPPI012578; -.
DR   Proteomes; UP000092460; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   CDD; cd15039; 7tmB3_Methuselah-like; 1.
DR   Gene3D; 2.30.160.11; -; 1.
DR   Gene3D; 2.170.180.11; Methuselah ectodomain, domain 2; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR044860; Methusela_ecto_dom_1.
DR   InterPro; IPR023311; Methusela_ecto_dom_2.
DR   InterPro; IPR010596; Methuselah_N_dom.
DR   InterPro; IPR036272; Methuselah_N_sf.
DR   PANTHER; PTHR47154; G-PROTEIN COUPLED RECEPTOR MTH-RELATED; 1.
DR   PANTHER; PTHR47154:SF2; G-PROTEIN COUPLED RECEPTOR MTH-RELATED; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF06652; Methuselah_N; 1.
DR   SUPFAM; SSF63877; Methuselah ectodomain; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        232..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        263..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        298..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          226..378
FT                   /note="G-protein coupled receptors family 2 profile 2"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
SQ   SEQUENCE   378 AA;  43705 MW;  B82153D94499D04E CRC64;
     MRIKMIITRE SYECCTLISF IIILLAFPIS AHNKEIPNCN YEDTVDLTNV QKFENDSYYY
     ESAILIPPER IGYYDFEELH NGRRVPVKPH LRGCVCDKYR CLKFCCHPTK ELIADETRQC
     GEYLQKEIEY DPHLSVILKN GSRSNLHALN DFFIVQGVPC EYAYAVVPEE DDLDGWDLFE
     NGTLYRHYDK AYIRKRDYCI HPYQLETGEW VLNPMNCPVE NVASLSSQIN NIAMAISVPF
     IILTILVYAF LPELRNLHGK CLISYLTSLA IGYSLLCTVT LTHAIFPPIS CSLLGYSAYF
     FLMAVFFWLS IISYDLWQNF RFTGSKRLTQ RKRFLMYSLY AWGGPLILTV CVIIAQASNL
     ENSLKPGIGD EYCWLKSK
//