ID A0A1B0BGB6_9MUSC Unreviewed; 649 AA.
AC A0A1B0BGB6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Ferric-chelate reductase 1 {ECO:0008006|Google:ProtNLM};
OS Glossina palpalis gambiensis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=67801 {ECO:0000313|EnsemblMetazoa:GPPI029099-PA, ECO:0000313|Proteomes:UP000092460};
RN [1] {ECO:0000313|Proteomes:UP000092460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000092460};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GPPI029099-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPPI029099-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FRRS1 family.
CC {ECO:0000256|ARBA:ARBA00009195}.
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DR EMBL; JXJN01013815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0BGB6; -.
DR STRING; 67801.A0A1B0BGB6; -.
DR EnsemblMetazoa; GPPI029099-RA; GPPI029099-PA; GPPI029099.
DR VEuPathDB; VectorBase:GPPI029099; -.
DR Proteomes; UP000092460; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08760; Cyt_b561_FRRS1_like; 1.
DR CDD; cd09628; DOMON_SDR_2_like; 1.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 1.20.120.1770; -; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM.
DR InterPro; IPR005018; DOMON_domain.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR PANTHER; PTHR45828; CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE; 1.
DR PANTHER; PTHR45828:SF38; FERRIC-CHELATE REDUCTASE 1 HOMOLOG-RELATED; 1.
DR Pfam; PF03351; DOMON; 1.
DR Pfam; PF02014; Reeler; 1.
DR SMART; SM00665; B561; 1.
DR PROSITE; PS50939; CYTOCHROME_B561; 1.
DR PROSITE; PS50836; DOMON; 1.
DR PROSITE; PS51019; REELIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..649
FT /note="Ferric-chelate reductase 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008404841"
FT TRANSMEM 404..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..191
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 240..364
FT /note="DOMON"
FT /evidence="ECO:0000259|PROSITE:PS50836"
FT DOMAIN 368..568
FT /note="Cytochrome b561"
FT /evidence="ECO:0000259|PROSITE:PS50939"
SQ SEQUENCE 649 AA; 72024 MW; 582EA81B03AB15D8 CRC64;
MMKEENRLVF FSSKIFVLLI VAQTLPRIYA FPNGAPEKVC DTMLPFHGGG ILPANSVPPF
RIETSSSVVG QGQVLRVYIA GVPNGLQFGG FMIQARQIRP PYEIMGQFNP SESGHSKLMN
CGNSVGNSAT HSHAGPKAEI SLEWQSPIDF EGDVIFNSTV AQSYDTFWVG IPSNTVRVVK
RDLAPQNYST PRPRFSPSSR PPYVPAYEQP VTTPMPDDPF YDECESAKIC FGIPDGCLEK
RNCVNAGAIK VRGNIHEFEI LCTAKDAAYV ALGLSDDDKM GDDLVTECVP QNGRVAMYSS
YTSAPPNGNY GAKRNGVPLT ARLVESSFIN GAIYCKVERD QTTKVGNRVF DLVNKKYFLL
LASGKSLKDA GVGYHDIIKS SSSKAISLAE IQSLSAASPI LLRLHGAFMI TAWIGTTSLG
IILARYFKQT WTGSQLCGKD QWFAWHRICM VSTWSLTMVA FVLIFVEING WSANQDRHAI
LGVVTTIICF IQPFGALFRP APNSKNRPIF NWLHWLGGNL AHLLAIVTIF YAVKLPKAEL
PEWMDWILVA YVAIHVIVHL IYSIAGCVSD RQQTQKINAF QMGDMSHHGL RNSMKMERKM
DAPVSMHGVL LKFFTYPLET VPYKMNIICV TVYLRFYSTG THIKSTFHP
//
